Search Results - "Doubek, Dennis L."

Isolation and Structures of Axistatins 1–3 from the Republic of Palau Marine Sponge Agelas axifera Hentschel by Pettit, George R, Tang, Yuping, Zhang, Qingwen, Bourne, Gregory T, Arm, Christoph A, Leet, John E, Knight, John C, Pettit, Robin K, Chapuis, Jean-Charles, Doubek, Dennis L, Ward, Franklin J, Weber, Christine, Hooper, John N. A

“…An investigation begun in 1979 directed at the Republic of Palau marine sponge Agelas axifera Hentschel for cancer cell growth inhibitory constituents…”
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Antineoplastic Agents. 520. Isolation and Structure of Irciniastatins A and B from the Indo-Pacific Marine Sponge Ircinia ramosa by PETTIT, George R., XU, Jun-Ping, CHAPUIS, Jean-Charles, PETTIT, Robin K., TACKETT, Larry P., DOUBEK, Dennis L., HOOPER, John N. A., SCHMIDT, Jean M.

“…The Indo-Pacific marine sponge Ircinia ramosa has been found to contain two powerful (GI50 from 0.001 to <0.0001 microg/mL) murine and human cancer cell growth…”
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Antineoplastic Agents. 556. Isolation and Structure of Coprinastatin 1 from Coprinus cinereus by Pettit, George R, Meng, Yanhui, Pettit, Robin K, Herald, Delbert L, Cichacz, Zbigniew A, Doubek, Dennis L, Richert, Linda

“…Cancer cell line bioassay-guided separation of an ethyl acetate extract prepared from a plant-associated fungus, Coprinus cinereus, led to the isolation of…”
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Antineoplastic Agents. 536. New Sources of Naturally Occurring Cancer Cell Growth Inhibitors from Marine Organisms, Terrestrial Plants, and Microorganisms by Pettit, George R, Hogan, Fiona, Xu, Jun-Ping, Tan, Rui, Nogawa, Toshihiko, Cichacz, Zbigniew, Pettit, Robin K, Du, Jiang, Ye, Qing-Hua, Cragg, Gordon M, Herald, Cherry L, Hoard, Michael S, Goswami, Animesh, Searcy, Justin, Tackett, Larry, Doubek, Dennis L, Williams, Lee, Hooper, John N. A, Schmidt, Jean M, Chapuis, Jean-Charles, Tackett, Denise N, Craciunescu, Felicia

“…Bioassay-guided fractionation of extracts of various plants, marine organisms, and microorganisms has led to the discovery of new natural sources of a number…”
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Antineoplastic agents. 510. Isolation and structure of dolastatin 19 from the Gulf of California sea hare Dolabella auricularia by Pettit, G.R, Xu, J.P, Doubek, D.L, Chapuis, J.C, Schmidt, J.M

“…The Gulf of California shell-less mollusc Dolabella auricularia has been found to contain a new 14-membered macrocyclic lactone linked to a…”
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Antineoplastic Agents. 380. Isolation and X-ray Crystal Structure Determination of Isoaaptamine from the Republic of Singapore Hymeniacidon sp. and Conversion to the Phosphate Prodrug Hystatin 1 by Pettit, George R, Hoffmann, Holger, McNulty, James, Higgs, Kerianne C, Murphy, Alison, Molloy, David J, Herald, Delbert L, Williams, Michael D, Pettit, Robin K, Doubek, Dennis L, Hooper, John N. A, Albright, Leslie, Schmidt, Jean M, Chapuis, Jean-Charles, Tackett, Larry P

“…By use of bioassay (murine P388 lymphocytic leukemia cell line) guided isolation procedures, extracts of the Republic of Singapore marine sponge Hymeniacidon…”
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Isolation and Structure of Cancer Cell Growth Inhibitory Tetracyclic Triterpenoids from the Zimbabwean Monadenium lugardae by Pettit, George R, Ye, Qinghua, Herald, Delbert L, Knight, John C, Hogan, Fiona, Melody, Noeleen, Mukku, Venugopal J. R. V, Doubek, Dennis L, Chapuis, Jean-Charles

“…The Zimbabwean medicinal plant Monadenium lugardae was evaluated as a potential source of new anticancer constituents. Four new tetracyclic triterpene (1–4)…”
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Antineoplastic Agents. 362. Isolation and X-ray Crystal Structure of Dibromophakellstatin from the Indian Ocean Sponge Phakellia mauritiana by Pettit, George R, McNulty, James, Herald, Delbert L, Doubek, Dennis L, Chapuis, Jean-Charles, Schmidt, Jean M, Tackett, Larry P, Boyd, Michael R

“…Bioassay-guided isolation procedures using human tumor cell lines led to isolation of dibromophakellstatin (4) from the Republic of Seychelles sponge Phakellia…”
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Isolation and Structure of Pedilstatin from a Republic of Maldives Pedilanthus sp by Pettit, George R, Ducki, Sylvie, Tan, Rui, Gardella, Roberta S, McMahon, James B, Boyd, Michael R, Pettit, George R, Blumberg, Peter M, Lewin, Nancy E, Doubek, Dennis L, Tackett, Larry P, Williams, Michael D

“…A new cancer cell growth inhibitor designated pedilstatin (1) was isolated from a Republic of Maldives Pedilanthus sp. The structure was determined to be…”
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Antineoplastic Agents. 587. Isolation and Structure of 3-Epipancratistatin from Narcissus cv. Ice Follies by Pettit, George R, Tan, Rui, Bao, Guan-Hu, Melody, Noeleen, Doubek, Dennis L, Gao, Song, Chapuis, Jean-Charles, Williams, Lee

“…Bioassay-guided (cancer cell line) separation of an extract prepared from Narcissus cv. Ice Follies (from The Netherlands) led to the isolation of a new…”
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Antineoplastic agents. 219. Isolation and structure of the cell growth inhibitory constituents from the western Pacific marine sponge Axinella sp by Pettit, George R, Herald, Cherry L, Boyd, Michael R, Leet, John E, Dufresne, Claude, Doubek, Dennis L, Schmidt, Jean M, Cerny, Ronald L, Hooper, John N. A, Rutzler, Klaus C

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Isolation and Structures of Schleicherastatins 1−7 and Schleicheols 1 and 2 from the Teak Forest Medicinal Tree Schleichera oleosa by Pettit, George R, Numata, Atsushi, Cragg, Gordon M, Herald, Delbert L, Takada, Tamie, Iwamoto, Chika, Riesen, Roland, Schmidt, Jean M, Doubek, Dennis L, Goswami, Animesh

“…Bioassay (P-388 lymphocytic leukemia cell line)-guided separation of an extract prepared from the bark and stem of the Sri Lankan tree Schleichera oleosa led…”
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Isolation and Structure of Ruprechstyril from Ruprechtia tangarana †,1 by Pettit, George R, Meng, Yanhui, Herald, Delbert L, Graham, Keith A. N, Pettit, Robin K, Doubek, Dennis L

“…Bioassay (P388 lymphocytic leukemia cell line and human cancer cell lines)-guided separation of an extract prepared from the stem bark and twigs of the…”
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Isolation and structure of ruprechstyril from Ruprechtia tangarana by Pettit, G.R, Meng, Y.H, Herald, D.L, Graham, K.A.N, Pettit, R.K, Doubek, D.L

“…Bioassay (P388 lymphocytic leukemia cell line and human cancer cell lines)-guided separation of an extract prepared from the stem bark and twigs of the…”
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Isolation and structural modification of 7-deoxynarciclasine and 7-deoxy-trans-dihydronarciclasine by Pettit, G.R, Eastham, S.A, Melody, N, Orr, B, Herald, D.L, McGregor, J, Knight, J.C, Doubek, D.L, Pettit, G.R. III, Garner, L.C

“…As an extension of structure-activity relationship studies of pancratistatin (1), various techniques were first evaluated for separating the mixtures of…”
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Antineoplastic agents. 278. Isolation and structure of axinastatins 2 and 3 from a Western Caroline Island marine sponge by Pettit, George R, Gao, Feng, Cerny, Ronald L, Doubek, Dennis L, Tackett, Larry P, Schmidt, Jean M, Chapuis, Jean-Charles

“…The Republic of Palau marine sponge Axinella sp. was found to be an exceptionally productive source of cell growth inhibitory substances. The strongly…”
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Antineoplastic Agents, 301. An Investigation of the Amaryllidaceae Genus Hymenocallis by Pettit, George R, Pettit, George R, Groszek, Grazyna, Backhaus, Ralph A, Doubek, Dennis L, Barr, Roland J, Meerow, Alan W

“…Seven species (and one cultivated variety) of Hymenocallis (Amaryllidaceae) and the related Pancratium maritima, representing a broad geographical selection,…”
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Antineoplastic Agents, 325. Isolation and Structure of the Human Cancer Cell Growth Inhibitory Cyclic Octapeptides Phakellistatin 10 and 11 from Phakellia sp by Pettit, George R, Tan, Rui, Ichihara, Yoshitatsu, Williams, Michael D, Doubek, Dennis L, Tackett, Larry P, Schmidt, Jean M, Cerny, Ronald L, Boyd, Michael R, Hooper, John N. A

“…The two new marine sponge (Phakellia sp., western Pacific Ocean) constituents, phakellistatin 10 [1] and 11 [2], were found to be cyclic octapeptides that…”
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Isolation and Structure of the Marine Sponge Cell Growth Inhibitory Cyclic Peptide Phakellistatin 1 by Pettit, George R, Cichacz, Zbigniew, Barkoczy, Josef, Dorsaz, Ann-Christine, Herald, Delbert L, Williams, Michael D, Doubek, Dennis L, Schmidt, Jean M, Tackett, Larry P, Brune, Daniel C, Cerny, Ronald L, Hooper, John N. A, Bakus, Gerald J

“…A new cell growth inhibitory (P-388 murine leukemia ED50 7.5 micrograms/ml) cycloheptapeptide designated phakellistatin 1 was isolated from two Indo-Pacific…”
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Antineoplastic Agents. 560. Isolation and Structure of Kitastatin 1 from an Alaskan Kitasatospora sp by Pettit, George R, Tan, Rui, Pettit, Robin K, Smith, Thomas H, Feng, Song, Doubek, Dennis L, Richert, Linda, Hamblin, John, Weber, Christine, Chapuis, Jean-Charles

“…By utilizing a bioassay-guided separation (P388 lymphocytic leukemia and a panel of human cancer cell lines) of fermentation broths from a Kitasatospora sp…”
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