Search Results - "Doubal, Fergus N"

Stroke subtype, vascular risk factors, and total MRI brain small-vessel disease burden by Staals, Julie, Makin, Stephen D.J, Doubal, Fergus N, Dennis, Martin S, Wardlaw, Joanna M

“…OBJECTIVES:In this cross-sectional study, we tested the construct validity of a “total SVD score,” which combines individual MRI features of small-vessel…”
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Perivascular spaces in the brain: anatomy, physiology and pathology by Wardlaw, Joanna M., Benveniste, Helene, Nedergaard, Maiken, Zlokovic, Berislav V., Mestre, Humberto, Lee, Hedok, Doubal, Fergus N., Brown, Rosalind, Ramirez, Joel, MacIntosh, Bradley J., Tannenbaum, Allen, Ballerini, Lucia, Rungta, Ravi L., Boido, Davide, Sweeney, Melanie, Montagne, Axel, Charpak, Serge, Joutel, Anne, Smith, Kenneth J., Black, Sandra E.

“…Perivascular spaces include a variety of passageways around arterioles, capillaries and venules in the brain, along which a range of substances can move…”
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Enlarged Perivascular Spaces on MRI Are a Feature of Cerebral Small Vessel Disease by DOUBAL, Fergus N, MACLULLICH, Alasdair M. J, FERGUSON, Karen J, DENNIS, Martin S, WARDLAW, Joanna M

“…Enlarged perivascular spaces in the brain are common but generally overlooked and of uncertain pathophysiology. They may reflect underlying cerebral small…”
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Vascular risk factors, large-artery atheroma, and brain white matter hyperintensities by Wardlaw, Joanna M, Allerhand, Michael, Doubal, Fergus N, Valdes Hernandez, Maria, Morris, Zoe, Gow, Alan J, Bastin, Mark, Starr, John M, Dennis, Martin S, Deary, Ian J

“…OBJECTIVE:To determine the magnitude of potentially causal relationships among vascular risk factors (VRFs), large-artery atheromatous disease (LAD), and…”
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Enlarged Perivascular Spaces and Cerebral Small Vessel Disease by Potter, Gillian M., Doubal, Fergus N., Jackson, Caroline A., Chappell, Francesca M., Sudlow, Cathie L., Dennis, Martin S., Wardlaw, Joanna M.

“…Background and aims Enlarged perivascular spaces (also known as Virchow-Robin spaces) on T2-weighted brain magnetic resonance imaging are common, but their…”
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Magnetic resonance imaging for assessment of cerebrovascular reactivity in cerebral small vessel disease: A systematic review by Blair, Gordon W, Doubal, Fergus N, Thrippleton, Michael J, Marshall, Ian, Wardlaw, Joanna M

“…Cerebral small vessel disease (SVD) pathophysiology is poorly understood. Cerebrovascular reactivity (CVR) impairment may play a role, but evidence to date is…”
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Blood―Brain Barrier Permeability and Long-Term Clinical and Imaging Outcomes in Cerebral Small Vessel Disease by WARDLAW, Joanna M, DOUBAL, Fergus N, VALDES-HERNANDEZ, Maria, XIN WANG, CHAPPELL, Francesca M, SHULER, Kirsten, ARMITAGE, Paul A, CARPENTER, Trevor C, DENNIS, Martin S

“…Increased blood-brain barrier (BBB) permeability occurs in cerebral small vessel disease. It is not known if BBB changes predate progression of small vessel…”
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Suitability of UK Biobank Retinal Images for Automatic Analysis of Morphometric Properties of the Vasculature by MacGillivray, Thomas J, Cameron, James R, Zhang, Qiuli, El-Medany, Ahmed, Mulholland, Carl, Sheng, Ziyan, Dhillon, Bal, Doubal, Fergus N, Foster, Paul J, Trucco, Emmanuel, Sudlow, Cathie

“…To assess the suitability of retinal images held in the UK Biobank--the largest retinal data repository in a prospective population-based cohort--for computer…”
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Sex Differences in Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis by Jiménez-Sánchez, Lorena, Hamilton, Olivia K L, Clancy, Una, Backhouse, Ellen V, Stewart, Catriona R, Stringer, Michael S, Doubal, Fergus N, Wardlaw, Joanna M

“…Cerebral small vessel disease (SVD) is a common cause of stroke, mild cognitive impairment, dementia and physical impairments. Differences in SVD incidence or…”
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A systematic review of dynamic cerebral and peripheral endothelial function in lacunar stroke versus controls by Stevenson, Susan F, Doubal, Fergus N, Shuler, Kirsten, Wardlaw, Joanna M

“…The etiology of cerebral small vessel disease is unknown. An association with endothelial dysfunction has been suggested. We systematically assessed all…”
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The Application of Optical Coherence Tomography Angiography in Cerebral Small Vessel Disease, Ischemic Stroke, and Dementia: A Systematic Review by Zhang, Jun-Fang, Wiseman, Stewart, Valdés-Hernández, Maria C, Doubal, Fergus N, Dhillon, Baljean, Wu, Yun-Cheng, Wardlaw, Joanna M

“…To investigate the application of optical coherence tomography angiography (OCTA) in cerebral small vessel disease (SVD), ischemic stroke and dementia. We…”
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Retinal microvascular network geometry and cognitive abilities in community-dwelling older people: The Lothian Birth Cohort 1936 study by McGrory, Sarah, Taylor, Adele M, Kirin, Mirna, Corley, Janie, Pattie, Alison, Cox, Simon R, Dhillon, Baljean, Wardlaw, Joanna M, Doubal, Fergus N, Starr, John M, Trucco, Emanuele, MacGillivray, Thomas J, Deary, Ian J

“…To examine the relationship between retinal vascular morphology and cognitive abilities in a narrow-age cohort of community-dwelling older people. Digital…”
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Clinical management of cerebral small vessel disease: a call for a holistic approach by Clancy, Una, Appleton, Jason P., Arteaga, Carmen, Doubal, Fergus N., Bath, Philip M., Wardlaw, Joanna M.

“…Cerebral small vessel disease (SVD) is a common global brain disease that causes cognitive impairment, ischemic or hemorrhagic stroke, problems with mobility,…”
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A Comparison of CVR Magnitude and Delay Assessed at 1.5 and 3T in Patients With Cerebral Small Vessel Disease by Stringer, Michael S, Blair, Gordon W, Shi, Yulu, Hamilton, Iona, Dickie, David A, Doubal, Fergus N, Marshall, Ian M, Thrippleton, Michael J, Wardlaw, Joanna M

“…Cerebrovascular reactivity (CVR) measures blood flow change in response to a vasoactive stimulus. Impairment is associated with several neurological conditions…”
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Counting Cavitating Lacunes Underestimates the Burden of Lacunar Infarction by POTTER, Gillian M, DOUBAL, Fergus N, JACKSON, Caroline A, CHAPPELL, Francesca M, SUDLOW, Cathie L, DENNIS, Martin S, WARDLAW, Joanna M

“…On brain imaging, lacunes, or cerebrospinal fluid-containing cavities, are common and are often counted in epidemiological studies as old lacunar infarcts. The…”
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Measuring axial length of the eye from magnetic resonance brain imaging by Wiseman, Stewart J, Tatham, Andrew J, Meijboom, Rozanna, Terrera, Graciela Muniz, Hamid, Charlene, Doubal, Fergus N, Wardlaw, Joanna M, Ritchie, Craig, Dhillon, Baljean, MacGillivray, Tom

“…Metrics derived from the human eye are increasingly used as biomarkers and endpoints in studies of cardiovascular, cerebrovascular and neurological disease. In…”
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Optimizing the Definitions of Stroke, Transient Ischemic Attack, and Infarction for Research and Application in Clinical Practice by Abbott, Anne L, Silvestrini, Mauro, Topakian, Raffi, Golledge, Jonathan, Brunser, Alejandro M, de Borst, Gert J, Harbaugh, Robert E, Doubal, Fergus N, Rundek, Tatjana, Thapar, Ankur, Davies, Alun H, Kam, Anthony, Wardlaw, Joanna M

“…Until now, stroke and transient ischemic attack (TIA) have been clinically based terms which describe the presence and duration of characteristic neurological…”
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What matters to people and families affected by cerebral small vessel disease (SVD)? A qualitative grounded theory investigation by Hwai, Sophia Wong Ching, Wardlaw, Joanna M., Williams, Anna, Doubal, Fergus N.

“…•Involving patients and families in small vessel disease research is a priority.•Cognitive decline was the main concern of people affected by SVD even if the…”
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Magnetic Resonance Imaging Tissue Signatures Associated With White Matter Changes Due to Sporadic Cerebral Small Vessel Disease Indicate That White Matter Hyperintensities Can Regress by Jochems, Angela C C, Muñoz Maniega, Susana, Clancy, Una, Arteaga, Carmen, Jaime Garcia, Daniela, Chappell, Francesca M, Hewins, Will, Locherty, Rachel, Backhouse, Ellen V, Barclay, Gayle, Jardine, Charlotte, McIntyre, Donna, Gerrish, Iona, Kampaite, Agniete, Sakka, Eleni, Valdés Hernández, Maria, Wiseman, Stewart, Bastin, Mark E, Stringer, Michael S, Thrippleton, Michael J, Doubal, Fergus N, Wardlaw, Joanna M

“…White matter hyperintensities (WMHs) might regress and progress contemporaneously, but we know little about underlying mechanisms. We examined WMH change and…”
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Towards Standardization of Quantitative Retinal Vascular Parameters: Comparison of SIVA and VAMPIRE Measurements in the Lothian Birth Cohort 1936 by McGrory, Sarah, Taylor, Adele M, Pellegrini, Enrico, Ballerini, Lucia, Kirin, Mirna, Doubal, Fergus N, Wardlaw, Joanna M, Doney, Alex S F, Dhillon, Baljean, Starr, John M, Trucco, Emanuele, Deary, Ian J, MacGillivray, Thomas J

“…Semiautomated software applications derive quantitative retinal vascular parameters from fundus camera images. However, the extent of agreement between…”
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