Search Results - "Dou, Xiaowei"

Chiral Phosphine Catalyzed Asymmetric Michael Addition of Oxindoles by Zhong, Fangrui, Dou, Xiaowei, Han, Xiaoyu, Yao, Weijun, Zhu, Qiang, Meng, Yuezhong, Lu, Yixin

“…Bifunctional phosphines derived from amino acids mediate the asymmetric Michael addition of 3‐substituted oxindoles to activated alkenes (see scheme)…”
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Enantioselective conjugate addition of 3-fluoro-oxindoles to vinyl sulfone: an organocatalytic access to chiral 3-fluoro-3-substituted oxindoles by Dou, Xiaowei, Lu, Yixin

“…An organocatalytic conjugate addition of prochiral 3-fluorinated oxindoles to vinyl sulfones was described for the first time. In the presence of bifunctional…”
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Short‐term rapamycin treatment increases ovarian lifespan in young and middle‐aged female mice by Dou, Xiaowei, Sun, Yan, Li, Jiazhao, Zhang, Jing, Hao, Dandan, Liu, Wenwen, Wu, Rui, Kong, Feifei, Peng, Xiaoxu, Li, Jing

“…Summary Although age‐related ovarian failure in female mammals cannot be reversed, recent strategies have focused on improving reproductive capacity with age,…”
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Enantioselective desymmetrization of cyclohexadienones via an intramolecular Rauhut–Currier reaction of allenoates by Yao, Weijun, Dou, Xiaowei, Wen, Shan, Wu, Ji’en, Vittal, Jagadese J., Lu, Yixin

“…The Rauhut–Currier (RC) reaction represents an efficient method for the construction of carbon–carbon bond in organic synthesis. However, the RC reactions…”
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Asymmetric synthesis of 3-spirocyclopropyl-2-oxindoles via intramolecular trapping of chiral aza-ortho-xylylene by Dou, Xiaowei, Yao, Weijun, Zhou, Bo, Lu, Yixin

“…Chiral aza-ortho-xylylene intermediates were efficiently generated from 3-chloro-3-substituted oxindole precursors. The first intramolecular trapping of chiral…”
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Asymmetric synthesis of P-stereogenic phosphindane oxides via kinetic resolution and their biological activity by Yin, Long, Li, Jiajia, Wu, Changhui, Zhang, Haoran, Zhao, Wenchao, Fan, Zhiyuan, Liu, Mengxuan, Zhang, Siqi, Guo, Mengzhe, Dou, Xiaowei, Guo, Dong

“…The importance of P -stereogenic heterocycles has been widely recognized with their extensive use as privileged chiral ligands and bioactive compounds. The…”
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From the Feist-Bénary Reaction to Organocatalytic Domino Michael-Alkylation Reactions: Asymmetric Synthesis of 3(2 H)-Furanones by Dou, Xiaowei, Han, Xiaoyu, Lu, Yixin

“…It all adds up! A modified Feist–Bénary reaction employing a domino Michael–alkylation sequence was designed for the enantioselective synthesis of 3(2…”
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Mesenchymal stem cells induce mature dendritic cells into a novel Jagged-2–dependent regulatory dendritic cell population by Zhang, Bin, Liu, Rui, Shi, Dan, Liu, Xingxia, Chen, Yuan, Dou, Xiaowei, Zhu, Xishan, Lu, Chunhua, Liang, Wei, Liao, Lianming, Zenke, Martin, Zhao, Robert C.H.

“…Mesenchymal stem cells (MSCs), in addition to their multilineage differentiation, exert immunomodulatory effects on immune cells, even dendritic cells (DCs)…”
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Wnt7a promotes the osteogenic differentiation of human mesenchymal stem cells by Yang, Leiluo, Li, Qing, Zhang, Junhong, Li, Pengcheng, An, Pingjiang, Wang, Chunqing, Hu, Pingsheng, Zou, Xue, Dou, Xiaowei, Zhu, Lixin

“…Mesenchymal stem cells (MSCs) have the ability of differentiating into osteoblasts. Elucidating the molecular mechanisms of MSC differentiation into…”
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Jagged-2 enhances immunomodulatory activity in adipose derived mesenchymal stem cells by Xishan, Zhu, Bin, Zhang, Haiyue, Zhao, Xiaowei, Dou, Jingwen, Bai, Guojun, Zhang

“…Adipose derived Mesenchymal stem cells (AMSCs) are able to expand in vitro and undergo differentiation into multiple cell lineages, yet have low immunogenicity…”
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Silencing Notch4 promotes tumorigenesis and inhibits metastasis of triple-negative breast cancer via Nanog and Cdc42 by Tian, Yuan, Zhang, Peipei, Mou, Yajun, Yang, Wenxiu, Zhang, Junhong, Li, Qing, Dou, Xiaowei

“…Elucidation of individual Notch protein biology in specific cancer is crucial to develop safe, effective, and tumor-selective Notch-targeting therapeutic…”
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Wnt7a Promotes the Occurrence and Development of Colorectal Adenocarcinoma by Li, Congcong, Dou, Xiaowei, Sun, Jiahuan, Xie, Min, Li, Hongli, Cui, Peilin

“…The expression of Wnt7a in colorectal cancer tissues and cell lines was analyzed, and the effect of Wnt7a on the proliferation of colorectal cancer cells was…”
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Overexpression of ΔNp63α induces a stem cell phenotype in MCF7 breast carcinoma cell line through the Notch pathway by Du, Zhijian, Li, Jing, Wang, Liang, Bian, Chunjing, Wang, Qingliang, Liao, Lianming, Dou, Xiaowei, Bian, Xiuwu, Zhao, Robert Chunhua

“…To elucidate a role of ΔNp63α in breast cancer, the expression levels of p63, estrogen receptor, progesterone receptor, p53, CK5, cerBb‐2, and Notch1 were…”
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Macrophage‐derived extracellular vesicles regulate follicular activation and improve ovarian function in old mice by modulating local environment by Xiao, Yue, Peng, Xiaoxu, Peng, Yue, Zhang, Chi, Liu, Wei, Yang, Weijie, Dou, Xiaowei, Jiang, Yuying, Wang, Yaxuan, Yang, Shuo, Xiang, Wenpei, Wu, Tinghe, Li, Jing

“…In mammals, ovarian function is dependent on the primordial follicle pool and the rate of primordial follicle activation determines a female's reproductive…”
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Restricting the induction of NGF in ovarian stroma engenders selective follicular activation through the mTOR signaling pathway by He, Yuanlin, Peng, Xiaoxu, Wu, Tinghe, Yang, Weijie, Liu, Wenwen, Zhang, Jing, Su, Yiping, Kong, Feifei, Dou, Xiaowei, Li, Jing

“…In mammalian ovaries, primordial follicles remain in a quiescent state until activation by the surrounding microenvironment. Ovarian intervention, for example,…”
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Patient-derived primary breast cancer cells and their potential for predicting sensitivity to chemotherapy by Mou, Yajun, Huang, Jianjun, Yang, Wenxiu, Wan, Yu, Pu, Zhenhong, Zhang, Junhong, Liu, Jinting, Li, Qing, Zhang, Peipei, Tian, Yuan, Yang, Hui, Cui, Yi, Hu, Pingsheng, Dou, Xiaowei

“…Chemotherapy resistance exposes patients to side effects and delays the effect of therapy in patients. So far, there are no predictive tools to predict…”
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VPS34 Governs Oocyte Developmental Competence by Regulating Mito/Autophagy: A Novel Insight into the Significance of RAB7 Activity and Its Subcellular Location by Liu, Wenwen, Wang, Kehan, Lin, Yuting, Wang, Lu, Jin, Xin, Qiu, Yuexin, Sun, Wenya, Zhang, Ling, Sun, Yan, Dou, Xiaowei, Luo, Shiming, Su, Youqiang, Sun, Qingyuan, Xiang, Wenpei, Diao, Feiyang, Li, Jing

“…Asynchronous nuclear and cytoplasmic maturation in human oocytes is believed to cause morphological anomalies after controlled ovarian hyperstimulation…”
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The Neural Stem Cell Properties of PKD2L1 + Cerebrospinal Fluid-Contacting Neurons in vitro by Wang, Shuo, He, Yuqi, Zhang, Huiqian, Chen, Li, Cao, Liang, Yang, Leiluo, Wang, Chunqing, Pan, Yujie, Tang, Qian, Tan, Wei, Dou, Xiaowei, Li, Qing

“…Cerebrospinal fluid-touching neurons (CSF-cNs) exist in the region surrounding the central canal of the spinal cord, which locate in the adult neurogenic…”
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Nutrient Intake Is Associated with Longevity Characterization by Metabolites and Element Profiles of Healthy Centenarians by Cai, Da, Zhao, Shancang, Li, Danlei, Chang, Fang, Tian, Xiangxu, Huang, Guohong, Zhu, Zhenjun, Liu, Dong, Dou, Xiaowei, Li, Shubo, Zhao, Mouming, Li, Quanyang

“…The relationships between diet and metabolites as well as element profiles in healthy centenarians are important but remain inconclusive. Therefore, to test…”
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Mutational analysis of compound heterozygous mutation p.Q6X/p.H232R in SRD5A2 causing 46,XY disorder of sex development by Li, Liwei, Zhang, Junhong, Li, Qing, Qiao, Li, Li, Pengcheng, Cui, Yi, Li, Shujun, Hao, Shirui, Wu, Tongqian, Liu, Lili, Yin, Jianmin, Hu, Pingsheng, Dou, Xiaowei, Li, Shuping, Yang, Hui

“…Over 100 mutations in the SRD5A2 gene have been identified in subjects with 46,XY disorder of sex development (DSD). Exploration of SRD5A2 mutations and…”
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