Search Results - "Dou, Q Ping"

Connecting copper and cancer: from transition metal signalling to metalloplasia by Ge, Eva J., Bush, Ashley I., Casini, Angela, Cobine, Paul A., Cross, Justin R., DeNicola, Gina M., Dou, Q. Ping, Franz, Katherine J., Gohil, Vishal M., Gupta, Sanjeev, Kaler, Stephen G., Lutsenko, Svetlana, Mittal, Vivek, Petris, Michael J., Polishchuk, Roman, Ralle, Martina, Schilsky, Michael L., Tonks, Nicholas K., Vahdat, Linda T., Van Aelst, Linda, Xi, Dan, Yuan, Peng, Brady, Donita C., Chang, Christopher J.

“…Copper is an essential nutrient whose redox properties make it both beneficial and toxic to the cell. Recent progress in studying transition metal signalling…”
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Novel metals and metal complexes as platforms for cancer therapy by Frezza, Michael, Hindo, Sarmad, Chen, Di, Davenport, Andrew, Schmitt, Sara, Tomco, Dajena, Dou, Q Ping

“…Metals are essential cellular components selected by nature to function in several indispensable biochemical processes for living organisms. Metals are endowed…”
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Tea in Health and Disease by Dou, Q Ping

“…Tea, including green tea made from the leaves of the plant, is the second most consumed beverage worldwide after water, and is consumed by more than two-thirds…”
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Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity by DI CHEN, CUI, Qiuzhi Cindy, HUANJIE YANG, PING DOU, Q

“…Disulfiram (DSF), a member of the dithiocarbamate family capable of binding copper and an inhibitor of aldehyde dehydrogenase, is currently being used…”
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Targeting the ubiquitin-proteasome system for cancer treatment: discovering novel inhibitors from nature and drug repurposing by Soave, Claire L., Guerin, Tracey, Liu, Jinbao, Dou, Q. Ping

“…In the past 15 years, the proteasome has been validated as an anti-cancer drug target and 20S proteasome inhibitors (such as bortezomib and carfilzomib) have…”
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Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4 by Skrott, Zdenek, Mistrik, Martin, Andersen, Klaus Kaae, Friis, Søren, Majera, Dusana, Gursky, Jan, Ozdian, Tomas, Bartkova, Jirina, Turi, Zsofia, Moudry, Pavel, Kraus, Marianne, Michalova, Martina, Vaclavkova, Jana, Dzubak, Petr, Vrobel, Ivo, Pouckova, Pavla, Sedlacek, Jindrich, Miklovicova, Andrea, Kutt, Anne, Li, Jing, Mattova, Jana, Driessen, Christoph, Dou, Q. Ping, Olsen, Jørgen, Hajduch, Marian, Cvek, Boris, Deshaies, Raymond J., Bartek, Jiri

“…Cancer incidence is rising and this global challenge is further exacerbated by tumour resistance to available medicines. A promising approach to meet the need…”
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Targeting apoptosis pathway with natural terpenoids: implications for treatment of breast and prostate cancer by Yang, Huanjie, Dou, Q Ping

“…Terpenoids represent a large and diverse class of naturally occurring compounds found in a variety of fruits, vegetables and medicinal plants. Structurally…”
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Growth arrest and apoptosis induction in androgen receptor-positive human breast cancer cells by inhibition of USP14-mediated androgen receptor deubiquitination by Liao, Yuning, Xia, Xiaohong, Liu, Ningning, Cai, Jianyu, Guo, Zhiqiang, Li, Yanling, Jiang, Lili, Dou, Q. Ping, Tang, Daolin, Huang, Hongbiao, Liu, Jinbao

“…It has been well known that androgen receptor (AR) is critical to prostate cancer development and progression. It has also been documented that AR is expressed…”
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Celastrol, a triterpene extracted from the Chinese thunder of god vine, is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice by HUANJIE YANG, DI CHEN, CUI, Qiuzhi Cindy, XIAO YUAN, PING DOU, Q

“…Interest in the use of traditional medicines for cancer prevention and treatment is increasing. In vitro, in vivo, and clinical studies suggest the potential…”
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Overview of proteasome inhibitor-based anti-cancer therapies: perspective on bortezomib and second generation proteasome inhibitors versus future generation inhibitors of ubiquitin-proteasome system by Dou, Q Ping, Zonder, Jeffrey A

“…Over the past ten years, proteasome inhibition has emerged as an effective therapeutic strategy for treating multiple myeloma (MM) and some lymphomas. In 2003,…”
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Targeting the ubiquitin-proteasome system for cancer therapy by Shen, Min, Schmitt, Sara, Buac, Daniela, Dou, Q Ping

“…The ubiquitin-proteasome system (UPS) degrades 80 - 90% of intracellular proteins. Cancer cells take advantage of the UPS for their increased growth and…”
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Everolimus Inhibits Growth of Gemcitabine‐Resistant Pancreatic Cancer Cells via Induction of Caspase‐Dependent Apoptosis and G2/M Arrest by Peng, Tao, Dou, Q. Ping

“…ABSTRACT Pancreatic cancer is the fourth leading cause of cancer‐related death in the United States. While Gemcitabine‐based chemotherapy is the first‐line…”
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Nanoparticle-mediated combination chemotherapy and photodynamic therapy overcomes tumor drug resistance by Khdair, Ayman, Di Chen, Patil, Yogesh, Ma, Linan, Dou, Q. Ping, Shekhar, Malathy P.V., Panyam, Jayanth

“…Tumor drug resistance significantly limits the success of chemotherapy in the clinic. Tumor cells utilize multiple mechanisms to prevent the accumulation of…”
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The ubiquitin-proteasome system as a prospective molecular target for cancer treatment and prevention by Chen, Di, Dou, Q Ping

“…Proteasomes are large multicatalytic proteinase complexes located in the cytosol and the nucleus of eukaryotic cells. The ubiquitin-proteasome system is…”
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Recent Advances in Antabuse (Disulfiram): The Importance of its Metal-binding Ability to its Anticancer Activity by Viola-Rhenals, Maricela, Patel, Kush R, Jaimes-Santamaria, Laura, Wu, Guojun, Liu, Jinbao, Dou, Q Ping

“…Considerable evidence demonstrates the importance of dithiocarbamates especially disulfiram as anticancer drugs. However there are no systematic reviews…”
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Novel Schiff Base Copper Complexes of Quinoline-2 Carboxaldehyde as Proteasome Inhibitors in Human Prostate Cancer Cells by Adsule, Shreelekha, Barve, Vivek, Chen, Di, Ahmed, Fakhara, Dou, Q. Ping, Padhye, Subhash, Sarkar, Fazlul H

“…We report the synthesis of novel 1:1 Schiff base copper complexes of quinoline-2-carboxaldehyde showing dose-dependent, antiproliferative, and proapoptotic…”
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A novel anticancer gold(III) dithiocarbamate compound inhibits the activity of a purified 20S proteasome and 26S proteasome in human breast cancer cell cultures and xenografts by MILACIC, Vesna, DI CHEN, RONCONI, Luca, LANDIS-PIWOWAR, Kristin R, FREGONA, Dolores, PING DOU, Q

“…Although cisplatin has been used for decades to treat human cancer, some toxic side effects and resistance are observed. It has been suggested that gold(III)…”
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Targeting the ubiquitin-proteasome pathway: an emerging concept in cancer therapy by Frezza, Michael, Schmitt, Sara, Dou, Q Ping

“…Selective degradation of proteins by the ubiquitin-proteasome pathway is a critical determinant for maintaining cellular homeostasis. Most intracellular…”
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Recent Advances in Repurposing Disulfiram and Disulfiram Derivatives as Copper-Dependent Anticancer Agents by Kannappan, Vinodh, Ali, Misha, Small, Benjamin, Rajendran, Gowtham, Elzhenni, Salena, Taj, Hamza, Wang, Weiguang, Dou, Q. Ping

“…Copper (Cu) plays a pivotal role in cancer progression by acting as a co-factor that regulates the activity of many enzymes and structural proteins in cancer…”
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Shikonin extracted from medicinal Chinese herbs exerts anti-inflammatory effect via proteasome inhibition by Lu, Li, Qin, Aiping, Huang, Hongbiao, Zhou, Ping, Zhang, Chuanyin, Liu, Ningning, Li, Shujue, Wen, Guanmei, Zhang, Change, Dong, Weihua, Wang, Xuejun, Dou, Q. Ping, Liu, Jinbao

“…Shikonin, extracted from medicinal Chinese herb ( Lithospermum erythrorhizo), was reported to exert anti-inflammatory and anti-cancer effects both in vitro and…”
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