Search Results - "Dou, Diana R"

Structural modularity of the XIST ribonucleoprotein complex by Lu, Zhipeng, Guo, Jimmy K., Wei, Yuning, Dou, Diana R., Zarnegar, Brian, Ma, Qing, Li, Rui, Zhao, Yang, Liu, Fan, Choudhry, Hani, Khavari, Paul A., Chang, Howard Y.

“…Long noncoding RNAs are thought to regulate gene expression by organizing protein complexes through unclear mechanisms. XIST controls the inactivation of an…”
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Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation by Carter, Ava C, Xu, Jin, Nakamoto, Meagan Y, Wei, Yuning, Zarnegar, Brian J, Shi, Quanming, Broughton, James P, Ransom, Ryan C, Salhotra, Ankit, Nagaraja, Surya D, Li, Rui, Dou, Diana R, Yost, Kathryn E, Cho, Seung-Woo, Mistry, Anil, Longaker, Michael T, Khavari, Paul A, Batey, Robert T, Wuttke, Deborah S, Chang, Howard Y

“…The lncRNA mediates X chromosome inactivation (XCI). Here we show that Spen, an -binding repressor protein essential for XCI , binds to ancient retroviral RNA,…”
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Xist ribonucleoproteins promote female sex-biased autoimmunity by Dou, Diana R, Zhao, Yanding, Belk, Julia A, Zhao, Yang, Casey, Kerriann M, Chen, Derek C, Li, Rui, Yu, Bingfei, Srinivasan, Suhas, Abe, Brian T, Kraft, Katerina, Hellström, Ceke, Sjöberg, Ronald, Chang, Sarah, Feng, Allan, Goldman, Daniel W, Shah, Ami A, Petri, Michelle, Chung, Lorinda S, Fiorentino, David F, Lundberg, Emma K, Wutz, Anton, Utz, Paul J, Chang, Howard Y

“…Autoimmune diseases disproportionately affect females more than males. The XX sex chromosome complement is strongly associated with susceptibility to…”
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Medial HOXA genes demarcate haematopoietic stem cell fate during human development by Dou, Diana R., Calvanese, Vincenzo, Sierra, Maria I., Nguyen, Andrew T., Minasian, Arazin, Saarikoski, Pamela, Sasidharan, Rajkumar, Ramirez, Christina M., Zack, Jerome A., Crooks, Gay M., Galic, Zoran, Mikkola, Hanna K. A.

“…Pluripotent stem cells (PSCs) may provide a potential source of haematopoietic stem/progenitor cells (HSPCs) for transplantation; however, unknown molecular…”
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Protagonist or antagonist? The complex roles of retinoids in the regulation of hematopoietic stem cells and their specification from pluripotent stem cells by Grace, Clea S., Mikkola, Hanna K.A., Dou, Diana R., Calvanese, Vincenzo, Ronn, Roger E., Purton, Louise E.

“…•We review the roles of retinoids in regulating hematopoietic stem cell (HSC) specification and self-renewal.•Our results reconcile the contradictory results…”
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Medial HOXA gene expression is required for establishing “stemness” in human HSCs by Dou, Diana R, Calvanese, Vincenzo, Sierra, Maria I, Sasidharan, Rajkumar, Zack, Jerome A, Crooks, Gay M, Galic, Zoran, Mikkola, Hanna

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Inability to Express HOXA Cluster and BCL11A Genes Compromises Self-Renewal and Multipotency of hESC-Derived Hematopoietic Cells by Dou, Diana R, Minasian, Arazin, Sierra, Maria I, Saarikoski, Pamela, Xu, Jian, Orkin, Stuart H., Prashad, Sacha L., Magnusson, Mattias, Zack, Jerome A., Crooks, Gay M., Galic, Zoran, Mikkola, Hanna K.A.

“…Abstract 1190 The inability to derive functional hematopoietic stem cells (HSCs) in vitro from pluripotent cells prevents widespread utilization of HSCs in the…”
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