Search Results - "Doty, J. L"

Cross-Coupling Methods for the Large-Scale Preparation of an Imidazole−Thienopyridine:  Synthesis of [2-(3-Methyl-3H-imidazol-4-yl)- thieno[3,2-b]pyridin-7-yl]-(2-methyl-1H-indol-5-yl)-amine by Ragan, J. A, Raggon, J. W, Hill, P. D, Jones, B. P, McDermott, R. E, Munchhof, M. J, Marx, M. A, Casavant, J. M, Cooper, B. A, Doty, J. L, Lu, Y

“…The multihundred-gram synthesis of [2-(3-methyl-3H-imidazol-4-yl)-thieno[3,2-b]pyridin-7-yl]-(2-methyl-1H-indol-5-yl)-amine (1) is described utilizing a Stille…”
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erbB-2 oncogene inhibition by geldanamycin derivatives: synthesis, mechanism of action, and structure-activity relationships by Schnur, R C, Corman, M L, Gallaschun, R J, Cooper, B A, Dee, M F, Doty, J L, Muzzi, M L, DiOrio, C I, Barbacci, E G, Miller, P E

“…Overexpression of the erbB-2 oncogene has been linked to poor prognosis in breast, ovarian, and gastric cancers. Naturally occurring benzoquinoid ansamycin…”
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Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: dynamics of receptor inhibition in situ and antitumor effects in athymic mice by Pollack, V A, Savage, D M, Baker, D A, Tsaparikos, K E, Sloan, D E, Moyer, J D, Barbacci, E G, Pustilnik, L R, Smolarek, T A, Davis, J A, Vaidya, M P, Arnold, L D, Doty, J L, Iwata, K K, Morin, M J

“…Phosphorylation of tyrosine residues on the epidermal growth factor (EGF) receptor (EGFr) is an important early event in signal transduction, leading to cell…”
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Inhibition of the oncogene product p185erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives by Schnur, R. C, Corman, M. L, Gallaschun, R. J, Cooper, B. A, Dee, M. F, Doty, J. L, Muzzi, M. L, Moyer, J. D, DiOrio, C. I

“…The erbB-2 oncogene encodes a transmembrane protein tyrosine kinase which plays a pivotal role in signal transduction and has been implicated when…”
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erbB-2 oncogene inhibition by geldanamycin derivatives: synthesis, mechanism of action, and structure-activity relationships by Schnur, R. C, Corman, M. L, Gallaschun, R. J, Cooper, B. A, Dee, M. F, Doty, J. L, Muzzi, M. L, DiOrio, C I, Barbacci, E. G

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Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor by Changelian, Paul S., Flanagan, Mark E., Ball, Douglas J., Kent, Craig R., Magnuson, Kelly S., Martin, William H., Rizzuti, Bonnie J., Sawyer, Perry S., Perry, Bret D., Brissette, William H., McCurdy, Sandra P., Kudlacz, Elizabeth M., Conklyn, Maryrose J., Elliott, Eileen A., Koslov, Erika R., Fisher, Michael B., Strelevitz, Timothy J., Yoon, Kwansik, Whipple, David A., Sun, Jianmin, Munchhof, Michael J., Doty, John L., Casavant, Jeffrey M., Blumenkopf, Todd A., Hines, Michael, Brown, Matthew F., Lillie, Brett M., Subramanyam, Chakrapani, Shang-Poa, Chang, Milici, Anthony J., Beckius, Gretchen E., Moyer, James D., Su, Chunyan, Woodworth, Thasia C., Gaweco, Anderson S., Beals, Chan R., Littman, Bruce H., Fisher, Douglas A., Smith, James F., Zagouras, Panayiotis, Magna, Holly A., Saltarelli, Mary J., Johnson, Kimberly S., Nelms, Linda F., Shelley G. Des Etages, Hayes, Lisa S., Kawabata, Thomas T., Finco-Kent, Deborah, Baker, Deanna L., Larson, Michael, Si, Ming-Sing, Paniagua, Ricardo, Higgins, John, Holm, Bari, Reitz, Bruce, Zhou, Yong-Jie, Morris, Randall E., O'Shea, John J., Borie, Dominic C.

“…Because of its requirement for signaling by multiple cytokines, Janus kinase 3 (JAK3) is an excellent target for clinical immunosuppression. We report the…”
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Design and SAR of thienopyrimidine and thienopyridine inhibitors of VEGFR-2 kinase activity by Munchhof, Michael J., Beebe, Jean S., Casavant, Jeffery M., Cooper, Beth A., Doty, Jonathan L., Higdon, R.Carla, Hillerman, Stephen M., Soderstrom, Catherine I., Knauth, Elisabeth A., Marx, Matthew A., Rossi, Ann Marie K., Sobolov, Susan B., Sun, Jianmin

“…Novel classes of thienopyrimidines and thienopyridines have been identified as potent inhibitors of VEGFR-2 kinase. The synthesis and SAR of these compounds is…”
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Development of a Scaleable Route for the Production of cis-N-Benzyl-3-methylamino-4-methylpiperidine by Ripin, David H. Brown, Abele, Stefan, Cai, Weiling, Blumenkopf, Todd, Casavant, Jeffrey M, Doty, Jonathan L, Flanagan, Mark, Koecher, Christian, Laue, Klaus W, McCarthy, Keith, Meltz, Cliff, Munchhoff, Mike, Pouwer, Kees, Shah, Bharat, Sun, Jianmin, Teixeira, John, Vries, Ton, Whipple, David A, Wilcox, Glenn

“…The synthesis of cis-N-benzyl-3-methylamino-4-methylpiperidine (5) via hydroboration of tetrahydropyridine 3 followed by oxidation and reductive amination was…”
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The use of the argon laser-assisted quartz scalpel for burn wound excision to fascia by Heimbach, D M, Neal, G D, Doty, J L, Lee, M J, Colocousis, J, Auth, D C

“…We have developed a new method for coupling the hemostatic capabilities of argon laser light with the mechanical advantages of a sharpened quartz blade using…”
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Inhibition of the oncogene product p185 super(erbB-2) in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives by Schnur, R C, Corman, M L, Gallaschun, R J, Cooper, BA, Dee, M F, Doty, J L, Muzzi, M L, Moyer, J D, DiOrio, C I, Barbacci, E G, Miller, P E, O'Brien, A T, Morin, MJ, Foster, BA, Pollack, V A

“…The erbB-2 oncogene encodes a transmembrane protein tyrosine kinase which plays a pivotal role in signal transduction and has been implicated when…”
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Communication is the key to buying optics by DOTY, J. L

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The Laser Photocoagulating Dielectric Waveguide Scalpel by Doty, James L., Auth, David C.

“…This paper presents the physical theory and engineering development of a new hemostatic scalpel, the photocoagulating dielectric waveguide scalpel. (laser…”
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