Search Results - "Doty, Crystal N"

In Vivo Evaluation of Candidate Allele-specific Mutant Huntingtin Gene Silencing Antisense Oligonucleotides by Southwell, Amber L, Skotte, Niels H, Kordasiewicz, Holly B, Østergaard, Michael E, Watt, Andrew T, Carroll, Jeffrey B, Doty, Crystal N, Villanueva, Erika B, Petoukhov, Eugenia, Vaid, Kuljeet, Xie, Yuanyun, Freier, Susan M, Swayze, Eric E, Seth, Punit P, Bennett, Clarence Frank, Hayden, Michael R

“…Huntington disease (HD) is a dominant, genetic neurodegenerative disease characterized by progressive loss of voluntary motor control, psychiatric disturbance,…”
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Allele-specific suppression of mutant huntingtin using antisense oligonucleotides: providing a therapeutic option for all Huntington disease patients by Skotte, Niels H, Southwell, Amber L, Østergaard, Michael E, Carroll, Jeffrey B, Warby, Simon C, Doty, Crystal N, Petoukhov, Eugenia, Vaid, Kuljeet, Kordasiewicz, Holly, Watt, Andrew T, Freier, Susan M, Hung, Gene, Seth, Punit P, Bennett, C Frank, Swayze, Eric E, Hayden, Michael R

“…Huntington disease (HD) is an inherited, fatal neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin gene. The mutant protein causes…”
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Cleavage at the Caspase-6 Site Is Required for Neuronal Dysfunction and Degeneration Due to Mutant Huntingtin by Graham, Rona K., Deng, Yu, Slow, Elizabeth J., Haigh, Brendan, Bissada, Nagat, Lu, Ge, Pearson, Jacqueline, Shehadeh, Jacqueline, Bertram, Lisa, Murphy, Zoe, Warby, Simon C., Doty, Crystal N., Roy, Sophie, Wellington, Cheryl L., Leavitt, Blair R., Raymond, Lynn A., Nicholson, Donald W., Hayden, Michael R.

“…Cleavage of huntingtin (htt) has been characterized in vitro, and accumulation of caspase cleavage fragments represents an early pathological change in brains…”
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Bidirectional Control of Postsynaptic Density-95 (PSD-95) Clustering by Huntingtin by Parsons, Matthew P., Kang, Rujun, Buren, Caodu, Dau, Alejandro, Southwell, Amber L., Doty, Crystal N., Sanders, Shaun S., Hayden, Michael R., Raymond, Lynn A.

“…Huntington disease is associated with early alterations in corticostriatal synaptic function that precede cell death, and it is postulated that ameliorating…”
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Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments by Warby, Simon C., Doty, Crystal N., Graham, Rona K., Shively, Jonathan, Singaraja, Roshni R., Hayden, Michael R.

“…Huntingtin is phosphorylated on serine-421 (S421) by the pro-survival signaling protein kinases Akt and SGK. Phosphorylation of huntingtin at S421 is variable…”
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Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS by Østergaard, Michael E., Southwell, Amber L., Kordasiewicz, Holly, Watt, Andrew T., Skotte, Niels H., Doty, Crystal N., Vaid, Kuljeet, Villanueva, Erika B., Swayze, Eric E., Frank Bennett, C., Hayden, Michael R., Seth, Punit P.

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HTT haplotypes contribute to differences in Huntington disease prevalence between Europe and East Asia by WARBY, Simon C, VISSCHER, Henk, COLLINS, Jennifer A, DOTY, Crystal N, CARTER, Catherine, BUTLAND, Stefanie L, HAYDEN, Anna R, KANAZAWA, Ichiro, ROSS, Colin J, HAYDEN, Michael R

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HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity by Mattis, Virginia B, Tom, Colton, Akimov, Sergey, Saeedian, Jasmine, Østergaard, Michael E, Southwell, Amber L, Doty, Crystal N, Ornelas, Loren, Sahabian, Anais, Lenaeus, Lindsay, Mandefro, Berhan, Sareen, Dhruv, Arjomand, Jamshid, Hayden, Michael R, Ross, Christopher A, Svendsen, Clive N

“…Huntington's disease (HD) is a fatal neurodegenerative disease, caused by expansion of polyglutamine repeats in the Huntingtin gene, with longer expansions…”
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Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS by Østergaard, Michael E, Southwell, Amber L, Kordasiewicz, Holly, Watt, Andrew T, Skotte, Niels H, Doty, Crystal N, Vaid, Kuljeet, Villanueva, Erika B, Swayze, Eric E, Bennett, C Frank, Hayden, Michael R, Seth, Punit P

“…Autosomal dominant diseases such as Huntington's disease (HD) are caused by a gain of function mutant protein and/or RNA. An ideal treatment for these diseases…”
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Huntingtin Haplotypes Provide Prioritized Target Panels for Allele-specific Silencing in Huntington Disease Patients of European Ancestry by Kay, Chris, Collins, Jennifer A, Skotte, Niels H, Southwell, Amber L, Warby, Simon C, Caron, Nicholas S, Doty, Crystal N, Nguyen, Betty, Griguoli, Annamaria, Ross, Colin J, Squitieri, Ferdinando, Hayden, Michael R

“…Huntington disease (HD) is a dominant neurodegenerative disorder caused by a CAG repeat expansion in the Huntingtin gene (HTT). Heterozygous polymorphisms in…”
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A SNP in the HTT promoter alters NF-κB binding and is a bidirectional genetic modifier of Huntington disease by Bečanović, Kristina, Nørremølle, Anne, Neal, Scott J, Kay, Chris, Collins, Jennifer A, Arenillas, David, Lilja, Tobias, Gaudenzi, Giulia, Manoharan, Shiana, Doty, Crystal N, Beck, Jessalyn, Lahiri, Nayana, Portales-Casamar, Elodie, Warby, Simon C, Connolly, Colúm, De Souza, Rebecca A G, Tabrizi, Sarah J, Hermanson, Ola, Langbehn, Douglas R, Hayden, Michael R, Wasserman, Wyeth W, Leavitt, Blair R

“…Huntington disease (HD) is an incurable neurodegenerative disease. A SNP in the huntingtin promoter impaired NF-κB binding and acted as a bidirectional…”
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HTT haplotypes contribute to differences in Huntington disease prevalence between Europe and East Asia by Warby, Simon C, Visscher, Henk, Collins, Jennifer A, Doty, Crystal N, Carter, Catherine, Butland, Stefanie L, Hayden, Anna R, Kanazawa, Ichiro, Ross, Colin J, Hayden, Michael R

“…Huntington disease (HD) results from CAG expansion in the huntingtin (HTT) gene. Although HD occurs worldwide, there are large geographic differences in its…”
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A fully humanized transgenic mouse model of Huntington disease by Southwell, Amber L, Warby, Simon C, Carroll, Jeffrey B, Doty, Crystal N, Skotte, Niels H, Zhang, Weining, Villanueva, Erika B, Kovalik, Vlad, Xie, Yuanyun, Pouladi, Mahmoud A, Collins, Jennifer A, Yang, X William, Franciosi, Sonia, Hayden, Michael R

“…Silencing the mutant huntingtin gene (muHTT) is a direct and simple therapeutic strategy for the treatment of Huntington disease (HD) in principle. However,…”
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High frequency of intermediate alleles on huntington disease-associated haplotypes in British Columbia's general population by Semaka, Alicia, Kay, Chris, Doty, Crystal N., Collins, Jennifer A., Tam, Natalie, Hayden, Michael R.

“…ABSTRACT Intermediate alleles (27–35 CAG, IAs) for Huntington disease (HD) usually do not confer the disease phenotype but are prone to CAG repeat instability…”
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Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease by Sutton, Liza M, Sanders, Shaun S, Butland, Stefanie L, Singaraja, Roshni R, Franciosi, Sonia, Southwell, Amber L, Doty, Crystal N, Schmidt, Mandi E, Mui, Katherine K N, Kovalik, Vlad, Young, Fiona B, Zhang, Weining, Hayden, Michael R

“…Palmitoylation, the dynamic post-translational addition of the lipid, palmitate, to proteins by Asp-His-His-Cys-containing palmitoyl acyltransferase (PAT)…”
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Huntington disease in the South African population occurs on diverse and ethnically distinct genetic haplotypes by Baine, Fiona K, Kay, Chris, Ketelaar, Maria E, Collins, Jennifer A, Semaka, Alicia, Doty, Crystal N, Krause, Amanda, Greenberg, L Jacquie, Hayden, Michael R

“…Huntington disease (HD) is a neurodegenerative disorder resulting from the expansion of a CAG trinucleotide repeat in the huntingtin (HTT) gene. Worldwide…”
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Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus by Warby, Simon C., Doty, Crystal N., Graham, Rona K., Carroll, Jeffrey B., Yang, Yu-Zhou, Singaraja, Roshni R., Overall, Christopher M., Hayden, Michael R.

“…Proteolysis of mutant huntingtin is crucial to the development of Huntington disease (HD). Specifically preventing proteolysis at the capase-6 (C6) consensus…”
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Reliable Resolution of Full-Length Huntingtin Alleles by Quantitative Immunoblotting by Caron, Nicholas S, Anderson, Christine, Black, Hailey Findlay, Sanders, Shaun S, Lemarié, Fanny L, Doty, Crystal N, Hayden, Michael R

“…Therapeutics that lower mutant huntingtin (mHTT) have shown promise in preclinical studies and are in clinical development for the treatment of Huntington…”
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Potent and Selective Antisense Oligonucleotides Targeting Single-Nucleotide Polymorphisms in the Huntington Disease Gene / Allele-Specific Silencing of Mutant Huntingtin by Carroll, Jeffrey B, Warby, Simon C, Southwell, Amber L, Doty, Crystal N, Greenlee, Sarah, Skotte, Niels, Hung, Gene, Bennett, C Frank, Freier, Susan M, Hayden, Michael R

“…Huntington disease (HD) is an autosomal dominant neurodegenerative disorder caused by CAG-expansion in the huntingtin gene (HTT) that results in a toxic gain…”
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A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles by Southwell, Amber L, Skotte, Niels H, Villanueva, Erika B, Østergaard, Michael E, Gu, Xiaofeng, Kordasiewicz, Holly B, Kay, Chris, Cheung, Daphne, Xie, Yuanyun, Waltl, Sabine, Dal Cengio, Louisa, Findlay-Black, Hailey, Doty, Crystal N, Petoukhov, Eugenia, Iworima, Diepiriye, Slama, Ramy, Ooi, Jolene, Pouladi, Mahmoud A, Yang, X William, Swayze, Eric E, Seth, Punit P, Hayden, Michael R

“…Huntington disease (HD) is a neurodegenerative disease caused by a mutation in the huntingtin (HTT) gene. HTT is a large protein, interacts with many partners…”
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