Search Results - "Dotto, Gian Paolo"

Sex Hormones and Anticancer Immunity by Özdemir, Berna C, Dotto, Gian-Paolo

“…The impact of sex hormones on anticancer immunity deserves attention due to the importance of the immune system in cancer therapy and the recognition of sex…”
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Sex Differences in Efficacy and Toxicity of Systemic Treatments: An Undervalued Issue in the Era of Precision Oncology by Özdemir, Berna C, Csajka, Chantal, Dotto, Gian-Paolo, Wagner, Anna Dorothea

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To be or not to be: The second law of thermodynamics and the flow of life and death by Dotto, Gian‐Paolo

“…Graphical Abstract Hamlet's question is the artist's expression of the meaning of life. The second law of thermodynamics is the physicist's equivalent…”
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Gender and sex—time to bridge the gap by Dotto, Gian‐Paolo

“…Graphical Abstract Interdisciplinary research and education are key for a better appreciation of sex and gender as defining a person, and for novel societal…”
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miR-181a decelerates proliferation in cutaneous squamous cell carcinoma by targeting the proto-oncogene KRAS by Neu, Johannes, Dziunycz, Piotr Jan, Dzung, Andreas, Lefort, Karine, Falke, Martin, Denzler, Rémy, Freiberger, Sandra Nicole, Iotzova-Weiss, Guergana, Kuzmanov, Aleksandar, Levesque, Mitchell Paul, Dotto, Gian-Paolo, Hofbauer, Günther Franz L

“…Cutaneous squamous cell carcinoma (SCC) is the second most common human skin cancer with a rapidly increasing incidence among the Caucasian population. Among…”
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Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice by Thomason, Helen A, Zhou, Huiqing, Kouwenhoven, Evelyn N, Dotto, Gian-Paolo, Restivo, Gaia, Nguyen, Bach-Cuc, Little, Hayley, Dixon, Michael J, van Bokhoven, Hans, Dixon, Jill

“…Cleft palate is a common congenital disorder that affects up to 1 in 2,500 live human births and results in considerable morbidity to affected individuals and…”
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Visualizing cellular heterogeneity by quantifying the dynamics of MAPK activity in live mammalian cells with synthetic fluorescent biosensors by Ma, Min, Bordignon, Pino, Dotto, Gian-Paolo, Pelet, Serge

“…Mitogen-Activated Protein Kinases (MAPKs) control a wide array of cellular functions by transducing extracellular information into defined biological…”
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CYFIP1 is directly controlled by NOTCH1 and down-regulated in cutaneous squamous cell carcinoma by Dziunycz, Piotr J, Neu, Johannes, Lefort, Karine, Djerbi, Nadia, Freiberger, Sandra N, Iotzova-Weiss, Guergana, French, Lars E, Dotto, Gian-Paolo, Hofbauer, Günther F

“…Squamous cell carcinoma of the skin (SCC) represents one of the most common cancers in the general population and is associated with a substantial risk of…”
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Mesenchymal cells in health and disease by Koliaraki, Vasiliki, Dotto, Gian-Paolo, Buckley, Christopher D., Kollias, George

“…On 3–8 June 2022, the First International Aegean Conference on Mesenchymal Cells in Health & Disease took place in Chania, Crete, and brought together…”
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Racial Differences in Cancer Susceptibility and Survival: More Than the Color of the Skin? by Özdemir, Berna C, Dotto, Gian-Paolo

“…Epidemiological studies point to race as a determining factor in cancer susceptibility. In US registries recording cancer incidence and survival by race…”
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Androgen receptor is a determinant of melanoma targeted drug resistance by Samarkina, Anastasia, Youssef, Markus Kirolos, Ostano, Paola, Ghosh, Soumitra, Ma, Min, Tassone, Beatrice, Proust, Tatiana, Chiorino, Giovanna, Levesque, Mitchell P., Goruppi, Sandro, Dotto, Gian Paolo

“…Melanoma provides a primary benchmark for targeted drug therapy. Most melanomas with BRAF V600 mutations regress in response to BRAF/MEK inhibitors…”
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A miR-34a-SIRT6 axis in the squamous cell differentiation network by Lefort, Karine, Brooks, Yang, Ostano, Paola, Cario-André, Muriel, Calpini, Valérie, Guinea-Viniegra, Juan, Albinger-Hegyi, Andrea, Hoetzenecker, Wolfram, Kolfschoten, Ingrid, Wagner, Erwin F, Werner, Sabine, Dotto, Gian Paolo

“…Squamous cell carcinomas (SCCs) are highly heterogeneous tumours, resulting from deranged expression of genes involved in squamous cell differentiation. Here…”
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A novel Nrf2-miR-29-desmocollin-2 axis regulates desmosome function in keratinocytes by Kurinna, Svitlana, Schäfer, Matthias, Ostano, Paola, Karouzakis, Emmanuel, Chiorino, Giovanna, Bloch, Wilhelm, Bachmann, Andreas, Gay, Steffen, Garrod, David, Lefort, Karine, Dotto, Gian-Paolo, Beer, Hans-Dietmar, Werner, Sabine

“…The Nrf2 transcription factor controls the expression of genes involved in the antioxidant defense system. Here, we identified Nrf2 as a novel regulator of…”
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HSD17B7 gene in self‐renewal and oncogenicity of keratinocytes from Black versus White populations by Xu, Xiaoying, Tassone, Beatrice, Ostano, Paola, Katarkar, Atul, Proust, Tatiana, Joseph, Jean‐Marc, Riganti, Chiara, Chiorino, Giovanna, Kutalik, Zoltan, Lefort, Karine, Dotto, Gian Paolo

“…Human populations of Black African ancestry have a relatively high risk of aggressive cancer types, including keratinocyte‐derived squamous cell carcinomas…”
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The Oncogene ATF3 Is Potentiated by Cyclosporine A and Ultraviolet Light A by Dziunycz, Piotr J., Lefort, Karine, Wu, Xunwei, Freiberger, Sandra N., Neu, Johannes, Djerbi, Nadia, Iotzowa-Weiss, Guergana, French, Lars E., Dotto, Gian-Paolo, Hofbauer, Günther F.L.

“…Cutaneous squamous cell carcinoma (SCC) represents the most important cutaneous complication following organ transplantation. It develops mostly on sun-exposed…”
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Increased Wnt Signaling Triggers Oncogenic Conversion of Human Breast Epithelial Cells by a Notch-Dependent Mechanism by Ayyanan, Ayyakannu, Civenni, Gianluca, Ciarloni, Laura, Morel, Catherine, Mueller, Nathalie, Lefort, Karine, Mandinova, Anna, Raffoul, Wassim, Fiche, Maryse, Dotto, Gian Paolo, Brisken, Cathrin

“…Wnt and Notch signaling have long been established as strongly oncogenic in the mouse mammary gland. Aberrant expression of several Wnts and other components…”
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Ambassadors of peace: The anthropology of war and how to overcome the human killing instinct by Dotto, Gian Paolo

“…Understanding the biological and evolutionary factors that make humans go to war may help to overcome our innate tendencies to kill each other…”
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Constitutively active Notch1 induces growth arrest of HPV-positive cervical cancer cells via separate signaling pathways by Talora, Claudio, Cialfi, Samantha, Segatto, Oreste, Morrone, Stefania, Kim Choi, John, Frati, Luigi, Paolo Dotto, Gian, Gulino, Alberto, Screpanti, Isabella

“…Notch signaling plays a key role in cell-fate determination and differentiation in different organisms and cell types. Several reports suggest that Notch…”
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Response by the author by Dotto, Gian Paolo

“…Graphical Abstract The response by the author…”
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To be or not to be by Dotto, Gian‐Paolo

“…Hamlet's question is the artist's expression of the meaning of life. The second law of thermodynamics is the physicist's equivalent…”
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