Immunological challenges associated with artificial skin grafts: available solutions and stem cells in future design of synthetic skin

Immunological challenges associated with artificial skin grafts: available solutions and stem cells in future design of synthetic skin

The repair or replacement of damaged skins is still an important, challenging public health problem. Immune acceptance and long-term survival of skin grafts represent the major problem to overcome in grafting given that in most situations autografts cannot be used. The emergence of artificial skin s...

Full description

Saved in:
Bibliographic Details
Published in:Journal of biological engineering Vol. 11; no. 1; p. 49
Main Authors: Dixit, Saurabh, Baganizi, Dieudonné R, Sahu, Rajnish, Dosunmu, Ejowke, Chaudhari, Atul, Vig, Komal, Pillai, Shreekumar R, Singh, Shree R, Dennis, Vida A
Format: Journal Article
Language:English
Published: England BioMed Central Ltd 13-12-2017
BioMed Central
BMC
Subjects:
Biological products
Biomaterial
Care and treatment
Immune rejection
Review
Scaffolds
Skin
Skin allograft
Skin care products
Skin tissue engineering
Stem cells
Tissue engineering
Transplantation
Immune rejection
Skin allograft
Stem cells
Biomaterial
Scaffolds
Skin tissue engineering
Skin substitutes
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The repair or replacement of damaged skins is still an important, challenging public health problem. Immune acceptance and long-term survival of skin grafts represent the major problem to overcome in grafting given that in most situations autografts cannot be used. The emergence of artificial skin substitutes provides alternative treatment with the capacity to reduce the dependency on the increasing demand of cadaver skin grafts. Over the years, considerable research efforts have focused on strategies for skin repair or permanent skin graft transplantations. Available skin substitutes include pre- or post-transplantation treatments of donor cells, stem cell-based therapies, and skin equivalents composed of bio-engineered acellular or cellular skin substitutes. However, skin substitutes are still prone to immunological rejection, and as such, there is currently no skin substitute available to overcome this phenomenon. This review focuses on the mechanisms of skin rejection and tolerance induction and outlines in detail current available strategies and alternatives that may allow achieving full-thickness skin replacement and repair.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1754-1611
1754-1611
DOI:10.1186/s13036-017-0089-9