Search Results - "Dostalik, Valerie"

Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies by Koblish, Holly, Li, Yun-Long, Shin, Niu, Hall, Leslie, Wang, Qian, Wang, Kathy, Covington, Maryanne, Marando, Cindy, Bowman, Kevin, Boer, Jason, Burke, Krista, Wynn, Richard, Margulis, Alex, Reuther, Gary W, Lambert, Que T, Dostalik Roman, Valerie, Zhang, Ke, Feng, Hao, Xue, Chu-Biao, Diamond, Sharon, Hollis, Greg, Yeleswaram, Swamy, Yao, Wenqing, Huber, Reid, Vaddi, Kris, Scherle, Peggy

“…The Proviral Integration site of Moloney murine leukemia virus (PIM) serine/threonine protein kinases are overexpressed in many hematologic and solid tumor…”
Get full text

The Novel Bromodomain and Extraterminal Domain Inhibitor INCB054329 Induces Vulnerabilities in Myeloma Cells That Inform Rational Combination Strategies by Stubbs, Matthew C, Burn, Timothy C, Sparks, Richard, Maduskuie, Thomas, Diamond, Sharon, Rupar, Mark, Wen, Xiaoming, Volgina, Alla, Zolotarjova, Nina, Waeltz, Paul, Favata, Margaret, Jalluri, Ravi, Liu, Huiqing, Liu, Xuesong Mike, Li, Jun, Collins, Robert, Falahatpisheh, Nikoo, Polam, Padmaja, DiMatteo, Darlise, Feldman, Patricia, Dostalik, Valerie, Thekkat, Pramod, Gardiner, Christine, He, Xin, Li, Yanlong, Covington, Maryanne, Wynn, Richard, Ruggeri, Bruce, Yeleswaram, Swamy, Xue, Chu-Biao, Yao, Wenqing, Combs, Andrew P, Huber, Reid, Hollis, Gregory, Scherle, Peggy, Liu, Phillip C C

“…Bromodomain and extraterminal domain (BET) proteins regulate the expression of many cancer-associated genes and pathways; BET inhibitors have demonstrated…”
Get full text

Abstract 430: Pemigatinib, an FGFR inhibitor, overcomes resistance to KRASG12C inhibitors in mesenchymal-like NSCLC tumors by Favata, Margaret, Weber, Michael, Abdollahi, Angela, Roman, Valerie Dostalik, Farren, Matt, Gilmartin, Aidan, Kim, Sunkyu, Wee, Susan, Rios-Doria, Jonathan

“…KRAS is one of the most frequently mutated oncogenes. Clinical studies with recently developed covalent KRASG12C inhibitors have shown promising anticancer…”
Get full text

Abstract 4704: The evaluation of INCB059872, an FAD-directed inhibitor of LSD1, in preclinical models of human small cell lung cancer by Lee, Sang Hyun, Liu, Xuesong Mike, Diamond, Melody, Dostalik, Valerie, Favata, Margaret, He, Chunhong, Wu, Liangxing, Wynn, Richard, Yao, Wenqing, Hollis, Gregory, Huber, Reid, Scherle, Peggy, Ruggeri, Bruce

“…Methylated histone marks on H3K4 and H3K9 are generally coupled with transcriptional activation and repression, respectively. Altered levels of these histone…”
Get full text

Abstract 1162: The evaluation of INCB059872, an FAD-directed covalent inhibitor of LSD1, in preclinical models of Ewing sarcoma by Roman, Valerie Dostalik, Ye, Min, Liu, Huiqing, Diamond, Melody, Chadderton, Antony, Lo, Yvonne, Liu, Xuesong M., Lu, Jin, He, Chunhong, Wu, Liangxing, Burn, Timothy, Wynn, Richard, Yao, Wenqing, Hollis, Gregory, Scherle, Peggy, Ruggeri, Bruce, Lee, Sang Hyun

“…Ewing sarcoma is a rare bone cancer affecting predominantly children. The chromosomal translocation of chromosomes 11 and 22 results in the EWS/FLI gene fusion…”
Get full text

Abstract 4702: Combination of BET inhibitor INCB054329 and LSD1 inhibitor INCB059872 is synergistic for the treatment of AML in vitro and in vivo by Liu, Xuesong, Stubbs, Matthew, Ye, Min, Collins, Roberts, Favata, Margaret, Yang, Gengjie, Diamond, Melody, Dostalik, Valerie, Lo, Yvonne, He, Chunhong, Wu, Liangxing, Combs, Andrew, Yao, Wenqing, Hollis, Gregory, Huber, Reid, Scherle, Peggy, Ruggeri, Bruce, Liu, Phillip, Lee, Sang Hyun

“…Acute myeloid leukemia (AML) is a disease characterized by the expansion of a hematopoietic stem cell like population caused in part by a block of myeloid…”
Get full text

Abstract 4712: Discovery of INCB059872, a novel FAD-directed LSD1 inhibitor that is effective in preclinical models of human and murine AML by Lee, Sang Hyun, Stubbs, Matthew, Liu, Xuesong Mike, Diamond, Melody, Dostalik, Valerie, Ye, Min, Lo, Yvonne, Favata, Margaret, Yang, Gengjie, Gallagher, Karen, Leffet, Lynn, He, Chunhong, Wu, Liangxing, Margulis, Alexander, Covington, Maryanne, Wynn, Richard, Yao, Wenqing, Hollis, Gregory, Huber, Reid, Ruggeri, Bruce, Scherle, Peggy

“…Acute myeloid leukemia (AML) is a disease characterized by the expansion of a hematopoietic stem cell like population caused in part by a block of myeloid…”
Get full text

Abstract 4696: The LSD1 inhibitor INCB059872 is synergistic with ATRA in models of non-APL acute myelogenous leukemia by Ye, Min, Liu, Mike, Lu, Jin, Lo, Yvonne, Favata, Margaret, Yang, Gengjie, Diamond, Melody, Dostalik, Valerie, Waeltz, Paul, Fischer, Melissa Ann, He, Chunhong, Wu, Liangxing, Shan, Xiaochuan, Chang, Hong, Covington, Maryanne, Li, Yanlong, Burn, Tim, Wynn, Richard, Yao, Wenqing, Hollis, Gregory, Huber, Reid, Scherle, Peggy, Savona, Michael, Carroll, Martin, Ruggeri, Bruce, Lee, Sang Hyun

“…Acute myeloid leukemia (AML) is a disease characterized by the expansion of a hematopoietic stem cell like population caused in part by a block of myeloid…”
Get full text

Abstract 692: The BET inhibitor INCB054329 is synergistic with JAK1 inhibition in models of multiple myeloma by Stubbs, Matthew C., Liu, Xuesong M., Wen, Xiaoming, Li, Jun, Dostalik, Valerie, O'Connor, Sybil, Caulder, Eian, Favata, Margaret, Rupar, Mark, Li, Yu, Rumberger, Beth, Maduskuie, Thomas, Sparks, Richard, Falahatpisheh, Nikoo, Polam, Padmaja, Vaddi, Kris, Burn, Timothy, Combs, Andrew P., Yao, Wenqing, Huber, Reid, Hollis, Gregory, Scherle, Peggy, Liu, Phillip CC

“…Bromodomain and Extra Terminal (BET) protein inhibitors have emerged as a potentially effective therapeutic option for multiple tumor types, through their…”
Get full text

Abstract 691: Activity of the BET inhibitor INCB054329 in models of multiple myeloma by Stubbs, Matthew, Wen, Xiaoming, Dostalik, Valerie, O'Connor, Sybil, Caulder, Eian, Vogina, Alla, Maduskuie, Thomas, Sparks, Richard, Huang, Taisheng, Falahatpisheh, Nikoo, Polam, Padmaja, Xue, Chu-Biao, Liu, Xuesong M., Burn, Timothy, Vaddi, Kris, Combs, Andrew P., Huber, Reid, Hollis, Gregory, Scherle, Peggy, Liu, Phillip CC

“…Multiple myeloma (MM) is a disease of plasma cell transformation. Current therapy for MM is initially effective, but nearly all tumors relapse, making new…”
Get full text

Abstract 5414: Activity of the pan-PIM kinase inhibitor INCB053914 in models of multiple myeloma by Koblish, Holly, Shin, Niu, Hall, Leslie, Wen, Xiaoming, O'Connor, Sybil, Dostalik, Valerie, Wang, Qian, Wang, Kathy, Covington, Maryanne, Marando, Cindy, Bowman, Kevin, Boer, Jason, Burke, Krista, Zhang, Ke, Feng, Hao, Xue, Chu-Biao, Li, Yun-Long, Yao, Wenqing, Huber, Reid, Vaddi, Kris, Scherle, Peggy

“…The PIM family of serine-threonine protein kinases (PIM1, PIM2 and PIM3) mediates responses to cytokines and growth factors and drives cell proliferation and…”
Get full text

Abstract B191: Preclinical assessment of targeting the PI3K/AKT pathway in combination with other signal transduction pathway inhibitors by Lee, Sang Hyun, Koblish, Holly, Liu, Xiangdong, Ye, Haifen, Li, Jun, Liu, Xuesong, Diamond, Melody, Zhang, Yue, Hall, Leslie, Dostalik, Valerie, Favata, Margaret, Behshad, Elham, Wynn, Richard, Li, Yun-long, Combs, Andrew, Xue, Chu-Bio, Yao, Wenqing, Hollis, Gregory, Huber, Reid, Scherle, Peggy

“…Inhibitors targeting the phosphoinositide 3-kinase (PI3K)/serine-threonine protein kinase B (AKT) pathway have been developed and have shown efficacy in…”
Get full text