Search Results - "Doseff, Andrea I."

Anti-Inflammatory Mechanisms of Dietary Flavones: Tapping into Nature to Control Chronic Inflammation in Obesity and Cancer by Kariagina, Anastasia, Doseff, Andrea I

“…Flavones are natural phytochemicals broadly distributed in our diet. Their anti-inflammatory properties provide unique opportunities to control the innate…”
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The Targeted Impact of Flavones on Obesity-Induced Inflammation and the Potential Synergistic Role in Cancer and the Gut Microbiota by Sudhakaran, Meenakshi, Doseff, Andrea I

“…Obesity is an inflammatory disease that is approaching pandemic levels, affecting nearly 30% of the world's total population. Obesity increases the risk of…”
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Role of Heterogeneous Nuclear Ribonucleoproteins in the Cancer-Immune Landscape by Sudhakaran, Meenakshi, Doseff, Andrea I

“…Cancer remains the second leading cause of death, accounting for approximately 20% of all fatalities. Evolving cancer cells and a dysregulated immune system…”
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Flavones: From Biosynthesis to Health Benefits by Jiang, Nan, Doseff, Andrea I, Grotewold, Erich

“…Flavones correspond to a flavonoid subgroup that is widely distributed in the plants, and which can be synthesized by different pathways, depending on whether…”
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Flavonoids: New Frontier for Immuno-Regulation and Breast Cancer Control by Sudhakaran, Meenakshi, Sardesai, Sagar, Doseff, Andrea I

“…Breast cancer (BC) remains the second most common cause of cancer-related deaths in women in the US, despite advances in detection and treatment. In addition,…”
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Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of apigenin human targets by Arango, Daniel, Morohashi, Kengo, Yilmaz, Alper, Kuramochi, Kouji, Parihar, Arti, Brahimaj, Bledi, Grotewold, Erich, Doseff, Andrea I

“…Flavonoids constitute the largest class of dietary phytochemicals, adding essential health value to our diet, and are emerging as key nutraceuticals. Cellular…”
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MYB31/MYB42 Syntelogs Exhibit Divergent Regulation of Phenylpropanoid Genes in Maize, Sorghum and Rice by Agarwal, Tina, Grotewold, Erich, Doseff, Andrea I., Gray, John

“…ZmMYB31 and ZmMYB42 are R2R3-MYB transcription factors implicated in the regulation of phenylpropanoid genes in maize. Here, we tested the hypothesis that the…”
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Caspase-11 Promotes the Fusion of Phagosomes Harboring Pathogenic Bacteria with Lysosomes by Modulating Actin Polymerization by Akhter, Anwari, Caution, Kyle, Abu Khweek, Arwa, Tazi, Mia, Abdulrahman, Basant A., Abdelaziz, Dalia H.A., Voss, Oliver H., Doseff, Andrea I., Hassan, Hoda, Azad, Abul K., Schlesinger, Larry S., Wewers, Mark D., Gavrilin, Mikhail A., Amer, Amal O.

“…Inflammasomes are multiprotein complexes that include members of the NLR (nucleotide-binding domain leucine-rich repeat containing) family and caspase-1. Once…”
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Monocytes and Macrophages Regulate Immunity through Dynamic Networks of Survival and Cell Death by Parihar, Arti, Eubank, Timothy D., Doseff, Andrea I.

“…Monocytes and macrophages are central cells of the innate immune system, responsible for defending against diverse pathogens. While they originate from a…”
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Dietary Flavonoids for Immunoregulation and Cancer: Food Design for Targeting Disease by Ahn-Jarvis, Jennifer H, Parihar, Arti, Doseff, Andrea I

“…Flavonoids, one of the most abundant phytochemicals in a diet rich in fruits and vegetables, have been recognized as possessing anti-proliferative,…”
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MicroRNAs Targeting Caspase-3 and -7 in PANC-1 Cells by Park, Jong Kook, Doseff, Andrea I, Schmittgen, Thomas D

“…MicroRNAs (miRNAs), a critical part of the RNA silencing machinery, are known to play important regulatory roles in cancer. However, the consequence of miRNA…”
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Transcriptome reprogramming through alternative splicing triggered by apigenin drives cell death in triple-negative breast cancer by Sudhakaran, Meenakshi, Navarrete, Tatiana García, Mejía-Guerra, Katherine, Mukundi, Eric, Eubank, Timothy D., Grotewold, Erich, Arango, Daniel, Doseff, Andrea I.

“…Triple-negative breast cancer (TNBC) is characterized by its aggressiveness and resistance to cancer-specific transcriptome alterations. Alternative splicing…”
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Dietary Apigenin Exerts Immune-Regulatory Activity in Vivo by Reducing NF-κB Activity, Halting Leukocyte Infiltration and Restoring Normal Metabolic Function by Cardenas, Horacio, Arango, Daniel, Nicholas, Courtney, Duarte, Silvia, Nuovo, Gerard J, He, Wei, Voss, Oliver H, Gonzalez-Mejia, M Elba, Guttridge, Denis C, Grotewold, Erich, Doseff, Andrea I

“…The increasing prevalence of inflammatory diseases and the adverse effects associated with the long-term use of current anti-inflammatory therapies prompt the…”
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Apigenin protects endothelial cells from lipopolysaccharide (LPS)-induced inflammation by decreasing caspase-3 activation and modulating mitochondrial function by Duarte, Silvia, Arango, Daniel, Parihar, Arti, Hamel, Patrice, Yasmeen, Rumana, Doseff, Andrea I

“…Acute and chronic inflammation is characterized by increased reactive oxygen species (ROS) production, dysregulation of mitochondrial metabolism and abnormal…”
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Lipidomic Adaptations in White and Brown Adipose Tissue in Response to Exercise Demonstrate Molecular Species-Specific Remodeling by May, Francis J., Baer, Lisa A., Lehnig, Adam C., So, Kawai, Chen, Emily Y., Gao, Fei, Narain, Niven R., Gushchina, Liubov, Rose, Aubrey, Doseff, Andrea I., Kiebish, Michael A., Goodyear, Laurie J., Stanford, Kristin I.

“…Exercise improves whole-body metabolic health through adaptations to various tissues, including adipose tissue, but the effects of exercise training on the…”
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Splicing reprogramming of TRAIL/DISC-components sensitizes lung cancer cells to TRAIL-mediated apoptosis by Voss, Oliver H., Arango, Daniel, Tossey, Justin C., Villalona Calero, Miguel A., Doseff, Andrea I.

“…Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selective killing of cancer cells underlines its anticancer potential. However, poor…”
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Maize Gene Regulatory Network for Phenolic Metabolism by Yang, Fan, Li, Wei, Jiang, Nan, Yu, Haidong, Morohashi, Kengo, Ouma, Wilberforce Zachary, Morales-Mantilla, Daniel E, Gomez-Cano, Fabio Andres, Mukundi, Eric, Prada-Salcedo, Luis Daniel, Velazquez, Roberto Alers, Valentin, Jasmin, Mejía-Guerra, Maria Katherine, Gray, John, Doseff, Andrea I, Grotewold, Erich

“…The translation of the genotype into phenotype, represented for example by the expression of genes encod- ing enzymes required for the biosynthesis of…”
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Binding of Caspase-3 Prodomain to Heat Shock Protein 27 Regulates Monocyte Apoptosis by Inhibiting Caspase-3 Proteolytic Activation by Voss, Oliver H., Batra, Sanjay, Kolattukudy, Sunny J., Gonzalez-Mejia, M. Elba, Smith, Jeffrey B., Doseff, Andrea I.

“…Caspase-3 is an essential executioner of apoptosis responsible for regulating many important cellular processes, among them the number of circulating…”
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Tart Cherry (Prunus cerasus L.) Pit Extracts Protect Human Skin Cells against Oxidative Stress: Unlocking Sustainable Uses for Food Industry Byproducts by Decot, Hannah, Sudhakaran, Meenakshi, Boismier, Emma, Schilmiller, Anthony, Claucherty, Ethan, Doseff, Andrea I, Aliakbarian, Bahar

“…Industrial processing of tart cherries (Prunus cerasus L.) produces bioproducts like cherry pits (CP), which contribute to adverse environmental effects. To…”
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Bioengineering of Genetically Encoded Gene Promoter Repressed by the Flavonoid Apigenin for Constructing Intracellular Sensor for Molecular Events by Desmet, Nicole M, Dhusia, Kalyani, Qi, Wenjie, Doseff, Andrea I, Bhattacharya, Sudin, Gilad, Assaf A

“…In recent years, Synthetic Biology has emerged as a new discipline where functions that were traditionally performed by electronic devices are replaced by…”
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