Search Results - "Dosanjh, M.K."

Site-directed mutagenesis for quantitation of base-base interactions at defined sites by Singer, B, Dosanjh, M K

“…Two alkylation products implicated in initiation of carcinogenesis are O6-alkylguanine (m6G) and O4-alkylthymine (m4T). We have used site-specific insertion of…”
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The Future of Global Radiation Oncology As Part of Accurate, Precision Cancer Medicine by Coleman, C.N., Dosanjh, M.K., Buchsbaum, J., Formenti, S., Pistenmaa, D.A.

“…Abstract only Background: When global health and cancer care are discussed, it is usually in the context of underserved communities, inadequate resources,…”
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Suppression of apoptosis by overexpression of Bcl-2 or Bcl-x L promotes survival and mutagenesis after oxidative damage by Cherbonnel-Lasserre, C., Dosanjh, M.K.

“…Apoptosis is the physiological process by which unwanted cells in an organism are killed. Bcl-2, a membrane-bound cytoplasmic protein, and its close relative…”
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Evidence from in vitro replication O[sup 6]-methylguanine can adopt multiple conformations by Dosanjh, M.K., Singer, B., Loechler, E.L.

“…The effect of O[sup 6]-methylguanine (m[sup 6]G) on replication, in a partially double-stranded defined 25-base oligonucleotide, has been studied under…”
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Human cells contain protein specifically binding to a single 1,N sup 6 -ethenoadenine in a DNA fragment by Rydberg, B., Dosanjh, M.K., Singer, B.

“…A human DNA binding protein has been characterized from cell-free extracts of liver, placenta, and cultured cells. This protein, apparent molecular mass…”
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Suppression of apoptosis by overexpression of Bcl-2 or Bcl-xL promotes survival and mutagenesis after oxidative damage by Cherbonnel-Lasserre, C, Dosanjh, M K

“…Apoptosis is the physiological process by which unwanted cells in an organism are killed. Bcl-2, a membrane-bound cytoplasmic protein, and its close relative…”
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Kinetics of extension of O sup 6 -methylguanine paired with cytosine or thymine in defined oligonucleotide sequences by Dosanjh, M.K., Galeros, G., Singer, B., Goodman, M.F.

“…The frequency of extending m{sup 6}G{center dot}C or m{sup 6}G{center dot}T pairs, when the 3{prime} and 5{prime} flanking neighbors of m{sup 6}G are either…”
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Effect of 3 prime flanking neighbors on kinetics of pairing of dCTP or dTTP opposite O sup 6 -methylguanine in a defined primed oligonucleotide when Escherichia coli DNA polymerase I is used by Singer, B., Chavez, F., Goodman, M.F., Essigmann, J.M., Dosanjh, M.K.

“…O{sup 6}-Methylguanine (m{sup 6}G) was incorporated site-specifically into two 25-base oligonucleotides differing only in the nucleotide on the 3{prime} side…”
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Both O4-methylthymine and O4-ethylthymine preferentially form alkyl T.G pairs that do not block in vitro replication in a defined sequence by Dosanjh, M K, Menichini, P, Eritja, R, Singer, B

“…The mutagenic potential of O4-methylthymine (m4T) and O4-ethylthymine (e4T) was determined by a primer extension assay on a 25mer oligonucleotide containing a…”
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The vinyl chloride DNA derivative N sup 2 ,3-ethenoguanine produces G yields A transitions in Escherichia coli by Cheng, K.C., Cahill, D.S., Loeb, L.A., Preston, B.D., Dosanjh, M.K., Singer, B.

“…Vinyl chloride is a known human and rodent carcinogen that forms several cyclic base derivatives in DNA. The mutagenic potential of these derivatives has been…”
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