Search Results - "Dosanjh, Davinder"

Prognostic Value of a T-Cell―Based, Interferon-γ Biomarker in Children with Tuberculosis Contact by BAKIR, Mustafa, MILLINGTON, Kerry A, SOYSAL, Ahmet, DEEKS, Jonathan J, EFEE, Serpil, ASLAN, Yasemin, DOSANJH, Davinder P. S, LALVANI, Ajit

“…Enzyme-linked immunospot (ELISpot) assay is an increasingly widely used, T-cell-based, interferon-gamma-release assay for diagnosing tuberculosis infection,…”
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Dynamic relationship between IFN-gamma and IL-2 profile of Mycobacterium tuberculosis-specific T cells and antigen load by Millington, Kerry A, Innes, John A, Hackforth, Sarah, Hinks, Timothy S C, Deeks, Jonathan J, Dosanjh, Davinder P S, Guyot-Revol, Valerie, Gunatheesan, Rubamalaar, Klenerman, Paul, Lalvani, Ajit

“…Distinct IFN-gamma and IL-2 profiles of Ag-specific CD4(+) T cells have recently been associated with different clinical disease states and Ag loads in viral…”
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Statin therapy in patients with community-acquired pneumonia by Grudzinska, Frances S, Dosanjh, Davinder PS, Parekh, Dhruv, Dancer, Rachel CA, Patel, Jaimin, Nightingale, Peter, Walton, Georgia M, Sapey, Elizabeth, Thickett, David R

“…Community-acquired pneumonia (CAP) is the leading cause of death from infection in developed countries. There is evidence of an association between improved…”
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Novel M tuberculosis antigen-specific T-cells are early markers of infection and disease progression by Dosanjh, Davinder P S, Bakir, Mustafa, Millington, Kerry A, Soysal, Ahmet, Aslan, Yasemin, Efee, Serpil, Deeks, Jonathan J, Lalvani, Ajit

“…Mycobacterium tuberculosis Region-of-Difference-1 gene products present opportunities for specific diagnosis of M. tuberculosis infection, yet immune responses…”
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Sepsis Induces a Dysregulated Neutrophil Phenotype That Is Associated with Increased Mortality by Thickett, David R., Dosanjh, Davinder, Scott, Aaron, Parekh, Dhruv, Sapey, Elizabeth, Patel, Jaimin M., Smith, Fang Gao

“…Background. Neutrophil dysfunction in sepsis has been implicated in the pathogenesis of multiorgan failure; however, the role of neutrophil extracellular traps…”
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Frequencies of Region of Difference 1 Antigen-Specific but Not Purified Protein Derivative-Specific Gamma Interferon-Secreting T Cells Correlate with the Presence of Tuberculosis Disease but Do Not Distinguish Recent from Remote Latent Infections by Hinks, Timothy S.C, Dosanjh, Davinder P.S, Innes, John A, Pasvol, Geoffrey, Hackforth, Sarah, Varia, Hansa, Millington, Kerry A, Liu, Xiao-Qing, Bakir, Mustafa, Soysal, Ahmet, Davidson, Robert N, Gunatheesan, Rubamalar, Lalvani, Ajit

“…The majority of individuals infected with Mycobacterium tuberculosis achieve lifelong immune containment of the bacillus. What constitutes this effective host…”
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Improved diagnostic evaluation of suspected tuberculosis by Dosanjh, Davinder P S, Hinks, Timothy S C, Innes, John A, Deeks, Jonathan J, Pasvol, Geoffrey, Hackforth, Sarah, Varia, Hansa, Millington, Kerry A, Gunatheesan, Rubamalar, Guyot-Revol, Valerie, Lalvani, Ajit

“…The role of new T-cell-based blood tests for tuberculosis in the diagnosis of active tuberculosis is unclear. To compare the performance of 2 interferon-gamma…”
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Resolution of Persistent COVID-19 After Convalescent Plasma in a Patient with B Cell Aplasia by McKemey, Emily, Shields, Adrian M., Faustini, Sian E., Hill, Harriet J., Barnskaya, Aliaksandra, Stamataki, Zania, Gompertz, Simon, Richter, Alex G., Dosanjh, Davinder, Madathil, Shyam

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Real-world retrospective observational study exploring the effectiveness and safety of antifibrotics in idiopathic pulmonary fibrosis by Wright, William Alexander, Crowley, Louise E, Parekh, Dhruv, Crawshaw, Anjali, Dosanjh, Davinder P, Nightingale, Peter, Thickett, David R

“…BackgroundPirfenidone and nintedanib are the only disease-modifying treatments available for idiopathic pulmonary fibrosis (IPF). Our aim was to test their…”
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Management of Non-Ventilated hospital acquired pneumonia by Pittaway, Harriet, Grudzinska, Frances, Livesey, Alana, Quarton, Samuel, Adiga, Aditya, Dosanjh, Davinder, Parekh, Dhruv

“…•NV-HAP is a unique entity when compared to other forms of pneumonia.•It should be treated as such in both research and management.•Treatment is supportive…”
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Utility of severity assessment tools in COVID-19 pneumonia: a multicentre observational study by Ahmed, Asim, Alderazi, Sayed A, Aslam, Rumaisa, Barkat, Barooq, Barker, Bethan L, Bhat, Rahul, Cassidy, Samuel, Crowley, Louise E, Dosanjh, Davinder PS, Ebrahim, Hussain, Elndari, Najla, Gardiner, Claudia, Gogokhia, Atena, Grudzinska, Frances S, Gurung, Megha T, Hughes, Terry, Ismail, Iyad, Iredale, Natasha, Irshad, Sannaan, Johnson, Sarah, Kavanagh, Diana, Knight, Thomas, Livesey, Alana, Lugg, Sebastian T, Marathe, Manoj, McDougall, Andrew, Nawaz, Wasim, Nettleton, Kimberly, O’Flynn, Lauren, Okoth, Kelvin, Parekh, Dhruv, Perry, Rita, Pudney, Elizabeth J, Sadiq, Ambreen, Soge, Olutobi, Soloman, Rhania, Soltan, Marina, Strecker, Martin, Thein, Onn S, Thickett, David, Thomas, Ajit, Thornton, Riah

“…Severity scores in pneumonia and sepsis are being applied to SARS-CoV-2 infection. We aimed to assess whether these severity scores are accurate predictors of…”
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PROphylaxis for paTiEnts at risk of COVID-19 infecTion (PROTECT-V) by Humphrey, Toby J L, Dosanjh, Davinder, Hiemstra, Thomas F, Richter, Alex, Chen-Xu, Michael, Qian, Wendi, Jha, Vivekanand, Gatley, Katrina, Adhikari, Rakshya, Dowling, Francis, Smith, Rona M

“…Despite the introduction of vaccination, there remains a need for pre-exposure prophylactic agents against SARS-CoV-2. Several patient groups are more…”
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Correction to: Resolution of Persistent COVID-19 After Convalescent Plasma in a Patient with B Cell Aplasia by McKemey, Emily, Shields, Adrian M., Faustini, Sian E., Hill, Harriet J., Baranskaya, Aliaksandra, Stamataki, Zania, Gompertz, Simon, Richter, Alex G., Dosanjh, Davinder, Madathil, Shyam

“…A Correction to this paper has been published: https://doi.org/10.1007/s10875-021-01029-z…”
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COVID-19 admission risk tools should include multiethnic age structures, multimorbidity and deprivation metrics for air pollution, household overcrowding, housing quality and adult skills by Soltan, Marina A, Varney, Justin, Sutton, Benjamin, Melville, Colin R, Lugg, Sebastian T, Parekh, Dhruv, Carroll, Will, Dosanjh, Davinder P, Thickett, David R

“…BackgroundEthnic minorities account for 34% of critically ill patients with COVID-19 despite constituting 14% of the UK population. Internationally,…”
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Early identification of severe community-acquired pneumonia: a retrospective observational study by Grudzinska, Frances S, Aldridge, Kerrie, Hughes, Sian, Nightingale, Peter, Parekh, Dhruv, Bangash, Mansoor, Dancer, Rachel, Patel, Jaimin, Sapey, Elizabeth, Thickett, David R, Dosanjh, Davinder P

“…BackgroundCommunity-acquired pneumonia (CAP) is a leading cause of sepsis worldwide. Prompt identification of those at high risk of adverse outcomes improves…”
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Increase in recruitment upon integration of trial into a clinical care pathway: an observational study by Yip, Kay Por, Gompertz, Simon, Snelson, Catherine, Willson, Jeremy, Madathil, Shyam, Huq, Syed SA, Rauf, Farrukh, Salmon, Natasha, Tengende, Joyce, Tracey, Julie, Cooper, Brendan, Filby, Kay, Ball, Simon, Parekh, Dhruv, Dosanjh, Davinder P S

“…IntroductionMany respiratory clinical trials fail to reach their recruitment target and this problem exacerbates existing funding issues. Integration of the…”
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Nebulised interferon-β1a (SNG001) in hospitalised COVID-19: SPRINTER phase III study by Monk, Phillip D, Brookes, Jody L, Tear, Victoria J, Batten, Toby N, Mankowski, Marcin, Adzic-Vukicevic, Tatjana, Crooks, Michael G, Dosanjh, Davinder P S, Kraft, Monica, Brightling, Christopher E, Gabbay, Felicity J, Holgate, Stephen T, Djukanovic, Ratko, Wilkinson, Tom M A

“…Despite the availability of vaccines and therapies, patients are being hospitalised with coronavirus disease 2019 (COVID-19). Interferon (IFN)-β is a naturally…”
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Use of T Cell-Based Diagnosis of Tuberculosis Infection to Optimize Interpretation of Tuberculin Skin Testing for Child Tuberculosis Contacts by Bakir, Mustafa, Dosanjh, Davinder P. S., Deeks, Jonathan J., Soysal, Ahmet, Millington, Kerry A., Efe, Serpil, Aslan, Yasemin, Polat, Dilek, Kodalli, Nihat, Yagci, Aysegul, Barlan, Isil, Bahceciler, Nerin, Demiralp, Emel E., Lalvani, Ajit

“…Background. Treatment of recent tuberculosis infection in children aged <2 years is essential, because of high risk of progression to disease, but diagnosis is…”
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Nebulised interferon beta-1a (SNG001) in hospitalised COVID-19: SPRINTER Phase III Study by Monk, Phillip D, Brookes, Jody L, Tear, Victoria J, Batten, Toby N, Mankowski, Marcin, Adzic-Vukicevic, Tatjana, Crooks, Michael G, Dosanjh, Davinder PS, Kraft, Monica, Brightling, Christopher E, Gabbay, Felicity J, Holgate, Stephen T, Djukanovic, Ratko, Wilkinson, Tom MA

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Evaluation of T-Cell Responses to Novel RD1- and RD2-Encoded Mycobacterium tuberculosis Gene Products for Specific Detection of Human Tuberculosis Infection by LIU, Xiao-Qing, DOSANJH, Davinder, VARIA, Hansa, EWER, Katie, COCKLE, Paul, PASVOL, Geoffrey, LALVANI, Ajit

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