Composition and evaluation of the anti-inflammatory and anticancer activities of the essential oil from Annona sylvatica A. St.-Hil

The essential oil from the leaves of Annona sylvatica (EOAS) was extracted by hydrodistillation, and the analysis was performed by gas chromatography-mass spectrometry. The main compounds identified in the EOAS were sesquiterpenes, such as hinesol, z-caryophyllene, β-maaliene, γ-gurjunene, silphiper...

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Bibliographic Details
Published in:	Journal of medicinal food Vol. 16; no. 1; p. 20
Main Authors:	Formagio, Anelise S N, Vieira, Maria do Carmo, Dos Santos, Luiz A C, Cardoso, Claúdia A L, Foglio, Mary Anny, de Carvalho, João Ernesto, Andrade-Silva, Magaiver, Kassuya, Cândida A L
Format:	Journal Article
Language:	English
Published:	United States 01-01-2013
Subjects:	Animals Annona - chemistry Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - chemistry Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Cell Line, Tumor Cell Proliferation - drug effects Edema - drug therapy Edema - immunology Humans Male Mice Neoplasms - drug therapy Neoplasms - physiopathology Oils, Volatile - administration & dosage Oils, Volatile - chemistry Plant Extracts - administration & dosage Plant Extracts - chemistry Plant Leaves - chemistry Sesquiterpenes - administration & dosage Sesquiterpenes - chemistry
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Summary:	The essential oil from the leaves of Annona sylvatica (EOAS) was extracted by hydrodistillation, and the analysis was performed by gas chromatography-mass spectrometry. The main compounds identified in the EOAS were sesquiterpenes, such as hinesol, z-caryophyllene, β-maaliene, γ-gurjunene, silphiperfol-5-en-3-ol, ledol, cubecol-1-epi, and muurola-3,5-diene. Oral administration of the EOAS (20 and 200 mg/kg) and subcutaneous injection of dexamethasone (0.5 mg/kg, reference drug) significantly inhibited carrageenan- and complete Freund's adjuvant-induced mouse paw edema. The anticancer activity the EOAS showed growth inhibitory activity on all cell lines when administered in a high concentration. The EOAS inhibited the growth of human cancer cell lines with GI(50) values in the range of 36.04-45.37 μg/mL on all of the cell lines tested. This work describes for the first time the anti-inflammatory and anticancer effects of the essential oil of A. sylvatica and its composition. Considering that drugs currently available for the treatment of inflammatory and cancer conditions show undesirable side-effects, the present results may have clinical relevance and open new possibilities for the development of novel anti-inflammatory and anticancer drugs.
ISSN:	1557-7600
DOI:	10.1089/jmf.2011.0303