Host-Guest Inclusion Complexes of Natural Products and Nanosystems: Applications in the Development of Repellents

Repellents are compounds that prevent direct contact between the hosts and the arthropods that are vectors of diseases. Several studies have described the repellent activities of natural compounds obtained from essential oils. In addition, these chemical constituents have been pointed out as alterna...

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Bibliographic Details
Published in:	Molecules (Basel, Switzerland) Vol. 27; no. 8; p. 2519
Main Authors:	Pena, Gueive Astur, da Costa Lopes, Anna Sylmara, de Morais, Sylvano Heleno Salgado, do Nascimento, Lidiane Diniz, Dos Santos, Fábio Rogério Rodrigues, da Costa, Kauê Santana, Alves, Cláudio Nahum, Lameira, Jerônimo
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 14-04-2022 MDPI
Subjects:	Arthropods Bioactive compounds Biocompatibility Biological Products - pharmacology Controlled release Delayed-Action Preparations Environmental protection Essential oils Inclusion complexes Insect Repellents - chemistry Insect Repellents - pharmacology Insects intermolecular interactions Lipids Mosquitoes nanoencapsulation nanosystems Natural products natural repellents Nature conservation Oils & fats Oils, Volatile - chemistry Oils, Volatile - pharmacology Organic chemistry Pheromones Polymers Proteins Repellents Review Shelf life Supramolecular compounds Thermal stability Toxicity Vectors VOCs Volatile organic compounds United States > US natural repellents nanoencapsulation controlled release intermolecular interactions nanosystems essential oils
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Summary:	Repellents are compounds that prevent direct contact between the hosts and the arthropods that are vectors of diseases. Several studies have described the repellent activities of natural compounds obtained from essential oils. In addition, these chemical constituents have been pointed out as alternatives to conventional synthetic repellents due to their interesting residual protection and low toxicity to the environment. However, these compounds have been reported with short shelf life, in part, due to their volatile nature. Nanoencapsulation provides protection, stability, conservation, and controlled release for several compounds. Here, we review the most commonly used polymeric/lipid nanosystems applied in the encapsulation of small organic molecules obtained from essential oils that possess repellent activity, and we also explore the theoretical aspects related to the intermolecular interactions, thermal stability, and controlled release of the nanoencapsulated bioactive compounds.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules27082519