Hemodynamic Assessment via Echocardiography During Propofol Anesthetic Induction in Healthy Dogs

Hemodynamic Assessment via Echocardiography During Propofol Anesthetic Induction in Healthy Dogs

Propofol is an intravenous anesthetic administered as a bolus or continuous infusion during anesthetic induction and maintenance. Its pharmacokinetic characteristics include hepatic and extrahepatic metabolism with a rapid onset of action and short duration, which provides a smooth anesthetic induct...

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Published in:Veterinary medicine international Vol. 2024; no. 1; p. 5541917
Main Authors: de Oliveira, Thais Cabral, Bispo, Guilherme Andraus, Poleto, Laura Beatriz de Socorro, Martinez, Francisco Dantas de Maio, de Souza, Max Túlio Rocha, Linhares, Lais Calazans Menescal, Taffarel, Marilda Onghero, Ferreira, Wagner Luís, Dos Santos, E Paulo Sérgio Patto
Format: Journal Article
Language:English
Published: United States John Wiley & Sons, Inc 2024
Hindawi Limited
Wiley
Subjects:
Alfentanil
Analgesics
Animals
Blood pressure
Catheters
Dogs
Doppler effect
Drug dosages
Echocardiography
Ejection fraction
Heart beat
Heart rate
Hemodynamics
Intubation
Narcotics
Parasitic diseases
Pharmacokinetics
Phenols
Physiological aspects
Propofol
Pulmonary arteries
Serology
Variables
Veterinary medicine
heart rate
myocardial function
hemodynamics
TIVA
stroke volume
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Summary:Propofol is an intravenous anesthetic administered as a bolus or continuous infusion during anesthetic induction and maintenance. Its pharmacokinetic characteristics include hepatic and extrahepatic metabolism with a rapid onset of action and short duration, which provides a smooth anesthetic induction without excitatory effects. To evaluate whether the isolated use of propofol in anesthetic induction in dogs changes the hemodynamic variables assessed via echocardiography. Prospective clinical study. Twelve healthy dogs. The dogs were induced with propofol (dose/effect) at 3 mg/kg/minute, and echocardiographic evaluations were performed immediately before anesthetic induction (MB) and immediately after its interruption (MI), at the end of the supply of the anesthetic agent. A significant reduction was observed between the values of the following hemodynamic variables: Ejection Fraction (EF%), which varied from 70% to 65% ( =0.011) between moments, and the Doppler Ejection Index (DEI), which ranged from 27.1 mL/beat/m to 22.4 mL/beat/m ( =0.044). The heart rate (HR) and the other studied hemodynamic variables showed no significant differences between the evaluated moments. Propofol was a safe anesthetic-inducing agent, maintaining stable hemodynamic indices during anesthetic induction at the used rate.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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Academic Editor: Juan Pablo Damián
ISSN:2090-8113
2042-0048
2042-0048
DOI:10.1155/2024/5541917