Association between cervical lesion grade and micronucleus frequency in the Papanicolaou test

The aim of this study was to evaluate the association between the frequency of micronuclei (MN) and the cellular changes detected in the conventional Papanicolaou test. One hundred and seventy-four Papanicolaou test smears with cellular changes were examined. MN screening was done in cytopathologica...

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Bibliographic Details
Published in:	Genetics and molecular biology Vol. 37; no. 3; pp. 496 - 499
Main Authors:	Bueno, Caroline Tanski, Dornelles da Silva, Cláudia Maria, Barcellos, Regina Bones, da Silva, Juliana, Dos Santos, Carla Rossana, Menezes, João Evangelista Sampaio, Menezes, Honório Sampaio, Rossetti, Maria Lucia Rosa
Format:	Journal Article
Language:	English
Published:	Brazil Sociedade Brasileira de Genética 01-09-2014
Subjects:	BIOCHEMISTRY & MOLECULAR BIOLOGY cervical cancer cervical lesions GENETICS & HEREDITY Human and Medical Genetics micronucleus Papanicolaou test cervical lesions micronucleus cervical cancer Papanicolaou test
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Summary:	The aim of this study was to evaluate the association between the frequency of micronuclei (MN) and the cellular changes detected in the conventional Papanicolaou test. One hundred and seventy-four Papanicolaou test smears with cellular changes were examined. MN screening was done in cytopathological smears by counting 1,000 cervical cells in a light microscope. MN frequencies were significantly higher in the group with cellular changes compared to the control group (p < 0.001). The mean MN frequencies were 0.95 ± 1.12 (mean ± SD) in the control group (n = 223), 2.98 ± 1.20 in individuals with atypical squamous cells of undetermined significance (ASC-US) (n = 50), 4.04 ± 1.45 in cervical intraepithelial neoplasia (CIN) I (n = 52), 5.97 ± 1.83 in CIN II (n = 30), 7.29 ± 1.55 in CIN III (n = 17) and 8.64 ± 1.55 in invasive cancer (n = 25). These findings suggest that MN monitoring should be included as an additional criterion for the early detection of cytogenetic damage in routine examinations. This monitoring should be done in the same smear as used for cytopathological examination. More specific and systematic studies are necessary to confirm this proposal.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1415-4757 1678-4685 1415-4757 1678-4685
DOI:	10.1590/S1415-47572014000400004