In vitro susceptibility of Cryptococcus gattii clinical isolates

In vitro susceptibility of Cryptococcus gattii clinical isolates

ABSTRACT The data available in the literature concerning Cryptococcus gattii in vitro antifungal susceptibility are contradictory. We have analyzed the activity of eight antifungal agents against 23 C. gattii clinical isolates and compared the susceptibility profiles with those of C. neoformans. MIC...

Full description

Saved in:
Bibliographic Details
Published in:Clinical microbiology and infection Vol. 14; no. 7; pp. 727 - 730
Main Authors: Gomez-Lopez, A., Zaragoza, O., Dos Anjos Martins, M., Melhem, M.C., Rodriguez-Tudela, J.L., Cuenca-Estrella, M.
Format: Journal Article
Language:English
Published: Oxford, UK Elsevier Ltd 01-07-2008
Blackwell Publishing Ltd
Blackwell
Subjects:
Amphotericin B - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antifungal agents
Antifungal Agents - pharmacology
Antifungal susceptibility testing
Biological and medical sciences
Cryptococcus
Cryptococcus - drug effects
Cryptococcus gattii
Cryptococcus neoformans - drug effects
Drug Resistance, Fungal
emerging yeast
EUCAST method
Fluconazole - pharmacology
Flucytosine - pharmacology
Humans
Infectious diseases
Medical sciences
Microbial Sensitivity Tests
Pharmacology. Drug treatments
posaconazole
Triazoles - pharmacology
Cryptococcus gattii
posaconazole
Antifungal susceptibility testing
emerging yeast
EUCAST method
Infection
Antifungal agent
Yeast
Drug susceptibility test
Triazole derivatives
Method
Posaconazole
Clinical isolate
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ABSTRACT The data available in the literature concerning Cryptococcus gattii in vitro antifungal susceptibility are contradictory. We have analyzed the activity of eight antifungal agents against 23 C. gattii clinical isolates and compared the susceptibility profiles with those of C. neoformans. MIC analysis (mg/L) revealed that C. gattii isolates were more susceptible to amphotericin B and flucytosine than were C. neoformans isolates. Fluconazole and other azole compounds showed high MIC values for C. gattii. Posaconazole displayed good activity. Further studies are required to ascertain the predictive value of the in vitro data presented here.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1198-743X
1469-0691
DOI:10.1111/j.1469-0691.2008.02021.x