Search Results - "Dortant, P"

Carcinogenic activity of benzo[a]pyrene in a 2 year oral study in Wistar rats by Wester, P.W., Muller, J.J.A., Slob, W., Mohn, G.R., Dortant, P.M., Kroese, E.D.

“…► There is high human oral exposure to PAHs. ► Benzo[a]pyrene can be used as a representative of PAHs. ► Benzo[a]pyrene was tested in an oral carcinogenicity…”
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Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA by Vries, Annemieke de, van Oostrom, Conny Th. M, Hofhuis, Frans M. A, Dortant, Paul M, Berg, Rob J. W, Gruijl, Frank R. de, Wester, Piet W, van Kreijl, Coen F, Capel, Peter J. A, Steeg, Harry van, Verbeek, Sjef J

“…Xeroderma pigmentosum patients with a defect in the nucleotide-excision repair gene XPA are characterized by, for example, a > 1,000-fold higher risk of…”
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Age-related differences in the toxicity of ochratoxin A in female rats by Dortant, P.M., Peters-Volleberg, G.W.M., Van Loveren, H., Marquardt, R.R., Speijers, G.J.A.

“…Ochratoxin A (OTA) is a mycotoxin found in food and feedstuffs of plant and animal origin. OTA exposure is related to nephropathy in humans. Age-related…”
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A new rat model of otitis media caused by Streptococcus pneumoniae : Conditions and application in immunization protocols by VAN DER VEN, L. T. M, VAN DEN DOBBELSTEEN, G. P. J. M, NAGARAJAH, B, VAN DIJKEN, H, DORTANT, P. M, VOS, J. G, ROHOLL, P. J. M

“…Streptococcus pneumoniae (pneumococcus [Pn]) can be cultured from up to 50% of acute otitis media (AOM) effusions, and these bacteria are the most common cause…”
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The role of urocanic acid in UVB‐induced suppression of immunity to Trichinella spiralis infection in the rat by Garssen, J, Norval, M, Crosby, J, Dortant, P, Van Loveren, H

“…The naturally occurring trans‐isomer of urocanic acid (trans‐UCA), found in the stratum corneum, absorbs ultraviolet light (UV) and isomerizes to the cis‐form…”
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The effect of oral quercetin on UVB-induced tumor growth and local immunosuppression in SKH-1 by Steerenberg, P.A., Garssen, J., Dortant, P.M., van der Vliet, H., Geerse, E., Verlaan, A.P.J., Goettsch, W.G., Sontag, Y., Bueno-de-Mesquita, H.B., Van Loveren, H.

“…The effects of quercetin (4%) on UVB-induced carcinogenesis and immunosuppression were studied in hairless SKH-1 mice exposed daily to suberythemal UVB for…”
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Evaluation of the OECD 421 reproductive toxicity screening test protocol using butyl benzyl phthalate by Piersma, A.H., Verhoef, A., Dortant, P.M.

“…The OECD421 reproductive toxicity screening test protocol was evaluated using the reproductive and developmental toxicant butyl benzyl phthalate (BBP). Female…”
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Use of Eμ-PIM-1 transgenic mice for short-term in vivo carcinogenicity testing : Lymphoma induction by benzo[a]pyrene, but not by TPA by KROESE, E. D, DORTANT, P. M, VAN STEEG, H, VAN OOSTROM, C. T. M, VAN DER HOUVEN VAN OORDT, C. W, VAN KRANEN, H. J, DE VRIES, A, WESTER, P. W, VAN KREIJL, C. F

“…E mu-pim-1 transgenic mice are predisposed to develop lymphomas. Due to their low spontaneous tumour incidence and their increased sensitivity towards the…”
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Ototoxicity of Tobramycin in Young Adult and Old Rats by Dormans, J.A.M.A., Peters-Volleberg, G.W.M., Dortant, P.M., Speijers, G.J.A.

“…To study the possible age-dependent ototoxic effects of tobramycin a subacute toxicity study was performed. To young adult (3 months) and old (27–30 months)…”
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Protection of UV-induced suppression of skin contact hypersensitivity: a common feature of flavonoids after oral administration by Steerenberg, P.A, Garssen, J, Dortant, P, Hollman, P.C, Alink, G.M, Dekker, M, Bueno-de-Mesquita, H.B, Loveren, H. van

“…In this study we investigated the effect of the dietary ingredients fruit and vegetable, green tea phenol extract (GTP) and the specific flavonoid components…”
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Investigation of a Screening Battery for Immunotoxicity of Pharmaceuticals Within a 28-Day Oral Toxicity Study Using Azathioprine and Cyclosporin A as Model Compounds by Dewaal, E.J., Timmerman, H.H., Dortant, P.M., Kranjc, M.A.M., Vanloveren, H.

“…The authors have investigated a panel of parameters for immunotoxicity that may be incorporated in routine screening for toxicity of pharmaceuticals. This…”
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Spontaneous liver tumors and Benzo[a]pyrene-induced lymphomas in XPA-deficient mice by de Vries, Annemieke, van Oostrom, Conny T. M., Dortant, Paul M., Beems, Rudolf B., van Kreijl, Coen F., Capel, Peter J. A., van Steeg, Harry

“…Defects in the xeroderma pigmentosum complementation group A‐correcting (XPA) gene, which encodes a component of the nucleotide excision repair (NER) pathway,…”
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Risk Assessment on the Carcinogenic Potential of Hybridoma Cell DNA: Implications for Residual Contaminating Cellular DNA in Biological Products by Dortant, P.M., Claassen, I.J.T.M., van Kreyl, C.F., van Steenis, G., Wester, P.W.

“…The aim of this study was to evaluate the possible carcinogenic potential of residual DNA derived from immortalized and possibly tumorigenic cell lines due to…”
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Quercetin prevents UV-induced local immunosuppression, but does not affect UV-induced tumor growth in SKH-1 hairless mice by Steerenberg, P A, Garssen, J, Dortant, P, van de Vliet, H, Geerse, L, Verlaan, A P, Goettsch, W, Sontag, Y, Norval, M, Gibbs, N K, Bueno-de-Mesquita, H B, Van Loveren, H

“…Ultraviolet is thought to induce skin tumors by its dual activity as a mutagenic agent and a suppressor of cell-mediated immunity. In the present study the…”
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Evaluation of the OECD 421 reproductive toxicity screening test protocol using 1-(butylcarbamoyl)-2-benzimidazolecarbamate (benomyl) by Piersma, A H, Verhoef, A, Dortant, P M

“…The OECD 421 reproductive toxicity screening test protocol was evaluated using the fungicide benomyl as a test compound at 10, 30, or 90 mg/kg per day. Male…”
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Comparison of Tobramycin Nephrotoxicity in Young Adult and Aged Female Rats by Peters‐Volleberg, Gertruda W. M., Dortant, Paul M., Speijers, Gerrit J. A.

“…: A two week toxicity study was performed in rats to study the possible age‐dependent toxicity of tobramycin, an aminoglycoside antibiotic with well known…”
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Effects of ultraviolet-B exposure on the resistance to Listeria monocytogenes in the rat by Goettsch, W, Garssen, J, de Klerk, A, Herremans, T M, Dortant, P, de Gruijl, F R, Van Loveren, H

“…A rat infection model using the bacterial pathogen Listeria monocytogenes was employed to analyze the immunosuppressive activity of UVB radiation. Rats were…”
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Methods for exposure of laboratory animals to ultraviolet radiation by Goettsch, W, Garssen, J, Gruijl, F.R. de, Dortant, P, Loveren, H. van

“…Two different sources of ultraviolet B (UVB radiation, an electronically controlled UVB exposure unit, containing FS40 tubes, and a hand-held Kromayer lamp,…”
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Protection of UV-induced Suppression of Skin Contact Hypersensitivity: A Common Feature of Flavonoids after Oral Administration? by Steerenberg, P. A., Garssen, J., Dortant, P., Hollman, P. C., Alink, G. M., Dekker, M., Bueno-de-Mesquita, H. B., Loveren, H. Van

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