Search Results - "Dorris, Martha"

The Human Leukocyte Antigen (HLA)-B27 Peptidome in Vivo, in Spondyloarthritis-susceptible HLA-B27 Transgenic Rats and the Effect of Erap1 Deletion by Barnea, Eilon, Melamed Kadosh, Dganit, Haimovich, Yael, Satumtira, Nimman, Dorris, Martha L., Nguyen, Mylinh T., Hammer, Robert E., Tran, Tri M., Colbert, Robert A., Taurog, Joel D., Admon, Arie

“…HLA-B27 is a class I major histocompatibility (MHC-I) allele that confers susceptibility to the rheumatic disease ankylosing spondylitis (AS) by an unknown…”
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Innate Immune Activation Can Trigger Experimental Spondyloarthritis in HLA-B27/Huβ2m Transgenic Rats by van Tok, Melissa N, Satumtira, Nimman, Dorris, Martha, Pots, Desirée, Slobodin, Gleb, van de Sande, Marleen G, Taurog, Joel D, Baeten, Dominique L, van Duivenvoorde, Leonie M

“…Spondyloarthritis (SpA) does not display the typical features of auto-immune disease. Despite the strong association with MHC class I, CD8 T cells are not…”
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Autoimmune epididymoorchitis is essential to the pathogenesis of male-specific spondylarthritis in HLA-B27-transgenic rats by Taurog, Joel D., Rival, Claudia, van Duivenvoorde, Leonie M., Satumtira, Nimman, Dorris, Martha L., Sun, Margaret, Shelton, John M., Richardson, James A., Hamra, F. Kent, Hammer, Robert E., Tung, Kenneth S. K.

“…Objective Male rats transgenic for HLA–B27 and human β2‐microglobulin (hβ2m) spontaneously develop epididymoorchitis (EO) preceding the development of…”
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HLA-B27 in Transgenic Rats Forms Disulfide-Linked Heavy Chain Oligomers and Multimers That Bind to the Chaperone BiP by Tran, Tri Minh, Satumtira, Nimman, Dorris, Martha L, May, Ekkehard, Wang, Andrew, Furuta, Eiichi, Taurog, Joel D

“…To test the hypothesis that HLA-B27 predisposes to disease by forming disulfide-linked homodimers, we examined rats transgenic for HLA-B27, mutant Cys(67)Ser…”
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Inflammatory disease in HLA-B27 transgenic rats by Taugor, Joel D., Maika, Shanna D., Satumtira, Nimman, Dorris, Martha L., McLean, Ian Lochlan, Yanagisawa, Hiromi, Sayad, Alain, Stagg, Andrew J., Fox, Graham M., Le O'Brein, Anne, Rehman, Muhammad, Zhou, Ming, Weiner, Allison L., Splawski, Judy B., Richardson, James A., Hammer, Robert E.

“…A spontaneous inflammatory disease in rats transgenic for HLAB27 resembles the B27‐associated human spondyloarthropathies, Colitis and arthritis, the two most…”
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Spondylarthritis in HLA–B27/human β2‐microglobulin–transgenic rats is not prevented by lack of CD8 by Taurog, Joel D., Dorris, Martha L., Satumtira, Nimman, Tran, Tri M., Sharma, Rohit, Dressel, Ralf, van den Brandt, Jens, Reichardt, Holger M.

“…Objective HLA–B27 predisposes to spondylarthritis by an unknown mechanism. A logical candidate mechanism is through recognition of B27 by CD8+ T cells. The…”
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HLA-B27 and human β2-microglobulin affect the gut microbiota of transgenic rats by Lin, Phoebe, Bach, Mary, Asquith, Mark, Lee, Aaron Y, Akileswaran, Lakshmi, Stauffer, Patrick, Davin, Sean, Pan, Yuzhen, Cambronne, Eric D, Dorris, Martha, Debelius, Justine W, Lauber, Christian L, Ackermann, Gail, Baeza, Yoshiki V, Gill, Tejpal, Knight, Rob, Colbert, Robert A, Taurog, Joel D, Van Gelder, Russell N, Rosenbaum, James T

“…The HLA-B27 gene is a major risk factor for clinical diseases including ankylosing spondylitis, acute anterior uveitis, reactive arthritis, and psoriatic…”
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Relationship between inflammation, bone destruction, and osteoproliferation in the HLA-B27/human β2-microglobulin-transgenic rat model of spondylarthritis by van Duivenvoorde, Leonie M., Dorris, Martha L., Satumtira, Nimman, van Tok, Melissa N., Redlich, Kurt, Tak, Paul P., Taurog, Joel D., Baeten, Dominique L.

“…Objective Inhibition of inflammation and destruction, but not of osteoproliferation, in patients with spondylarthritis (SpA) treated with anti–tumor necrosis…”
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Mechanism of Simultaneous Iodination and Coupling Catalyzed by Thyroid Peroxidase by Taurog, Alvin, Dorris, Martha L., Doerge, Daniel R.

“…Thyroid peroxidase (TPO) simultaneously catalyzes two very different types of reaction in the thyroid gland—iodination and coupling. The present study…”
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Additional human β2‐microglobulin curbs HLA–B27 misfolding and promotes arthritis and spondylitis without colitis in male HLA–B27–transgenic rats by Tran, Tri M., Dorris, Martha L., Satumtira, Nimman, Richardson, James A., Hammer, Robert E., Shang, Jie, Taurog, Joel D.

“…Objective Ankylosing spondylitis and related spondylarthritides are associated with HLA–B27, and also with intestinal inflammation, by unknown mechanisms. The…”
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CD8αβ T Cells Are Not Essential to the Pathogenesis of Arthritis or Colitis in HLA-B27 Transgenic Rats by May, Ekkehard, Dorris, Martha L., Satumtira, Nimman, Iqbal, Imran, Rehman, Muhammad I., Lightfoot, Ellis, Taurog, Joel D.

“…Abstract The class I MHC allele HLA-B27 is highly associated with the human spondyloarthropathies, but the basis for this association remains poorly…”
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Correlation between dendritic cell functional defect and spondylarthritis phenotypes in HLA–B27/HUMAN β2‐microglobulin–transgenic rat lines by Fert, Ingrid, Glatigny, Simon, Poulain, Cécile, Satumtira, Nimman, Dorris, Martha L., Taurog, Joel D., Breban, Maxime

“…Objective To examine the functional capacity of dendritic cells (DCs) from a panel of HLA–B27/human β2‐microglobulin (Huβ2m)–transgenic rat lines and crosses…”
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CD8 alpha beta T cells are not essential to the pathogenesis of arthritis or colitis in HLA-B27 transgenic rats by May, Ekkehard, Dorris, Martha L, Satumtira, Nimman, Iqbal, Imran, Rehman, Muhammad I, Lightfoot, Ellis, Taurog, Joel D

“…The class I MHC allele HLA-B27 is highly associated with the human spondyloarthropathies, but the basis for this association remains poorly understood…”
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Relationship between inflammation, bone destruction, and osteoproliferation in the HLA-B27/human [beta]2-microglobulin-transgenic rat model of spondylarthritis by van Duivenvoorde, Leonie M, Dorris, Martha L, Satumtira, Nimman, van Tok, Melissa N, Redlich, Kurt, Tak, Paul P, Taurog, Joel D, Baeten, Dominique L

“…Objective Inhibition of inflammation and destruction, but not of osteoproliferation, in patients with spondylarthritis (SpA) treated with anti-tumor necrosis…”
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HLA-B27 and Human [beta]2-Microglobulin Affect the Gut Microbiota of Transgenic Rats by Lin, Phoebe, Bach, Mary, Asquith, Mark, Lee, Aaron Y, Akileswaran, Lakshmi, Stauffer, Patrick, Davin, Sean, Pan, Yuzhen, Cambronne, Eric D, Dorris, Martha, Debelius, Justine W, Lauber, Christian L, Ackermann, Gail, Baeza, Yoshiki V, Gill, Tejpal, Knight, Rob, Colbert, Robert A, Taurog, Joel D, Van Gelder, Russell N, Rosenbaum, James T

“…The HLA-B27 gene is a major risk factor for clinical diseases including ankylosing spondylitis, acute anterior uveitis, reactive arthritis, and psoriatic…”
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The selenium analog of methimazole. Measurement of its inhibitory effect on type I 5'-deiodinase and of its antithyroid activity by Taurog, A, Dorris, M L, Guziec, L J, Guziec, Jr, F S

“…Methimazole (MMI), unlike propylthiouracil (PTU) is a poor inhibitor of type I iodothyronine deiodinase (ID-1). Inhibition of the enzyme by PTU was attributed…”
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A reexamination of the proposed inactivation of thyroid peroxidase in the rat thyroid by propylthiouracil by Taurog, A, Dorris, M L

“…The antithyroid drug 6-propylthiouracil (PTU) was previously shown in our laboratory to have an unexpectedly prolonged inhibitory effect on iodination in the…”
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Enzymatic deglycosylation of porcine thyroid peroxidase: effects on catalytic activity and immunoreactivity by Moura, E G, Pazos-Moura, C C, Yokoyama, N, Dorris, M L, Taurog, A

“…Thyroid peroxidase is a heme-containing, membrane-bound, glycoprotein enzyme that catalyzes iodination and coupling in the thyroid gland. It is also the…”
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HLA-B27 and Human beta 2-Microglobulin Affect the Gut Microbiota of Transgenic Rats: e105684 by Lin, Phoebe, Bach, Mary, Asquith, Mark, Lee, Aaron Y, Akileswaran, Lakshmi, Stauffer, Patrick, Davin, Sean, Pan, Yuzhen, Cambronne, Eric D, Dorris, Martha

“…The HLA-B27 gene is a major risk factor for clinical diseases including ankylosing spondylitis, acute anterior uveitis, reactive arthritis, and psoriatic…”
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An unexpected side reaction in the guaiacol assay for peroxidase by Taurog, A, Dorris, M L, Guziec, Jr, F S

“…In routine guaiacol assays for thyroid peroxidase and lactoperoxidase employing a newly purchased bottle of guaiacol from Aldrich Chemical Co., we were…”
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