Search Results - "Dorrance, Anne M."

The effects of hypertension on the cerebral circulation by Pires, Paulo W, Dams Ramos, Carla M, Matin, Nusrat, Dorrance, Anne M

“…Maintenance of brain function depends on a constant blood supply. Deficits in cerebral blood flow are linked to cognitive decline, and they have detrimental…”
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Direct regulation of blood pressure by smooth muscle cell mineralocorticoid receptors by McCurley, Amy, Pires, Paulo W, Bender, Shawn B, Aronovitz, Mark, Zhao, Michelle J, Metzger, Daniel, Chambon, Pierre, Hill, Michael A, Dorrance, Anne M, Mendelsohn, Michael E, Jaffe, Iris Z

“…The mineralocorticoid receptor, targeted by drugs commonly used to treat hypertension, is generally thought to contribute to hypertension by altering kidney…”
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Activation of ventral tegmental area neurotensin Receptor-1 neurons promotes weight loss by Perez-Bonilla, Patricia, Santiago-Colon, Krystal, Matasovsky, Jillian, Ramirez-Virella, Jariel, Khan, Rabail, Garver, Hannah, Fink, Gregory, Dorrance, Anne M., Leinninger, Gina M.

“…Dopamine (DA) neurons in the ventral tegmental area (VTA) modulate physical activity and feeding behaviors that are disrupted in obesity. Yet, the…”
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Endothelial Mineralocorticoid Receptor Mediates Parenchymal Arteriole and Posterior Cerebral Artery Remodeling During Angiotensin II–Induced Hypertension by Diaz-Otero, Janice M, Fisher, Courtney, Downs, Kelsey, Moss, M Elizabeth, Jaffe, Iris Z, Jackson, William F, Dorrance, Anne M

“…The brain is highly susceptible to injury caused by hypertension because the increased blood pressure causes artery remodeling that can limit cerebral…”
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Mineralocorticoid receptor antagonism improves parenchymal arteriole dilation via a TRPV4-dependent mechanism and prevents cognitive dysfunction in hypertension by Diaz-Otero, Janice M, Yen, Ting-Chieh, Fisher, Courtney, Bota, Daniel, Jackson, William F, Dorrance, Anne M

“…Hypertension and mineralocorticoid receptor activation cause cerebral parenchymal arteriole remodeling; this can limit cerebral perfusion and contribute to…”
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Bilateral common carotid artery stenosis in normotensive rats impairs endothelium-dependent dilation of parenchymal arterioles by Matin, Nusrat, Fisher, Courtney, Jackson, William F, Dorrance, Anne M

“…Chronic cerebral hypoperfusion is a risk factor for cognitive impairment. Reduced blood flow through the common carotid arteries induced by bilateral carotid…”
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Chemerin connects fat to arterial contraction by Watts, Stephanie W, Dorrance, Anne M, Penfold, Mark E, Rourke, Jillian L, Sinal, Christopher J, Seitz, Bridget, Sullivan, Timothy J, Charvat, Trevor T, Thompson, Janice M, Burnett, Robert, Fink, Gregory D

“…Obesity and hypertension are comorbid in epidemic proportion, yet their biological connection is largely a mystery. The peptide chemerin is a candidate for…”
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The effects of obesity on the cerebral vasculature by Dorrance, Anne M, Matin, Nusrat, Pires, Paulo W

“…The incidence of obesity in the population is increasing at an alarming rate, with this comes an increased risk of insulin resistance (IR). Obesity and IR…”
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Regulation of ion channels in the microcirculation by mineralocorticoid receptor activation by Chambers, Laura, Dorrance, Anne M

“…The mineralocorticoid receptor (MR) has classically been studied in the renal epithelium for its role in regulating sodium and water balance and, subsequently,…”
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Carotid artery stenosis in hypertensive rats impairs dilatory pathways in parenchymal arterioles by Matin, Nusrat, Fisher, Courtney, Jackson, William F, Diaz-Otero, Janice M, Dorrance, Anne M

“…Hypertension is a leading risk factor for vascular cognitive impairment and is strongly associated with carotid artery stenosis. In normotensive rats, chronic…”
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Mineralocorticoid receptor antagonism prevents obesity‐induced cerebral artery remodeling and reduces white matter injury in rats by Pires, Paulo W., McClain, Jonathon L., Hayoz, Sebastian F., Dorrance, Anne M.

“…Objective Midlife obesity is a risk factor for dementia development. Obesity has also been linked to hyperaldosteronism, and this can be modeled in rats by…”
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Regulation of Gene Expression in the Mammalian Eye and Its Relevance to Eye Disease by Scheetz, Todd E., Kim, Kwang-Youn A., Swiderski, Ruth E., Philp, Alisdair R., Braun, Terry A., Knudtson, Kevin L., Dorrance, Anne M., DiBona, Gerald F., Huang, Jian, Casavant, Thomas L., Sheffield, Val C., Stone, Edwin M.

“…We used expression quantitative trait locus mapping in the laboratory rat (Rattus norvegicus) to gain a broad perspective of gene regulation in the mammalian…”
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Transient receptor potential vanilloid 4 channels are important regulators of parenchymal arteriole dilation and cognitive function by Diaz‐Otero, Janice M., Yen, Ting‐Chieh, Ahmad, Amna, Laimon‐Thomson, Erinn, Abolibdeh, Bana, Kelly, Kara, Lewis, Matthew T., Wiseman, Robert W., Jackson, William F., Dorrance, Anne M.

“…Objective Hypertension‐associated PA dysfunction reduces cerebral perfusion and impairs cognition. This is associated with impaired TRPV4‐mediated PA dilation;…”
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Doxycycline, a matrix metalloprotease inhibitor, reduces vascular remodeling and damage after cerebral ischemia in stroke-prone spontaneously hypertensive rats by Pires, Paulo W, Rogers, Curt T, McClain, Jonathon L, Garver, Hannah S, Fink, Gregory D, Dorrance, Anne M

“…Matrix metalloproteases (MMPs) are a family of zinc peptidases involved in extracellular matrix turnover. There is evidence that increased MMP activity is…”
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Improvement in Middle Cerebral Artery Structure and Endothelial Function in Stroke-Prone Spontaneously Hypertensive Rats after Macrophage Depletion by Pires, Paulo W., Girgla, Saavia S., McClain, Jonathon L., Kaminski, Norbert E., van Rooijen, Nico, Dorrance, Anne M.

“…Background Inflammation is involved in the pathogenesis of hypertension. Hypertensive animals have an increased number of perivascular macrophages in cerebral…”
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NADH/NADPH Oxidase and Enhanced Superoxide Production in the Mineralocorticoid Hypertensive Rat by Beswick, Richard A, Dorrance, Anne M, Leite, Romulo, Webb, R Clinton

“…We previously reported increased aortic reactive oxygen species (ROS) production in mineralocorticoid (deoxycorticosterone acetate [DOCA]-salt) hypertensive…”
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DOCA-salt hypertension impairs artery function in rat middle cerebral artery and parenchymal arterioles by Matin, Nusrat, Pires, Paulo W., Garver, Hannah, Jackson, William F., Dorrance, Anne M.

“…Objective Chronic hypertension induces detrimental changes in the structure and function of surface cerebral arteries. Very little is known about PAs, which…”
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Effects of Stroke on the Autonomic Nervous System by Dorrance, Anne M, Fink, Greg

“…Stroke is the fourth leading cause of death in the United States and the second most common cause of death worldwide; stroke is also the leading cause of…”
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Glycemic control prevents microvascular remodeling and increased tone in type 2 diabetes: link to endothelin-1 by Sachidanandam, Kamakshi, Hutchinson, Jim R, Elgebaly, Mostafa M, Mezzetti, Erin M, Dorrance, Anne M, Motamed, Kouros, Ergul, Adviye

“…Medial thickening and vascular hypertrophy of resistance arteries can lead to cardiovascular complications associated with diabetes. While previous studies…”
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STIM1/Orai1 contributes to sex differences in vascular responses to calcium in spontaneously hypertensive rats by Giachini, Fernanda R C, Lima, Victor V, Filgueira, Fernando P, Dorrance, Anne M, Carvalho, Maria Helena C, Fortes, Zuleica B, Webb, R Clinton, Tostes, Rita C

“…Sex differences in Ca2+-dependent signalling and homoeostasis in the vasculature of hypertensive rats are well characterized. However, sex-related differences…”
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