Search Results - "Dorr, Robert T."

Pharmacokinetics and Safety of Green Tea Polyphenols after Multiple-Dose Administration of Epigallocatechin Gallate and Polyphenon E in Healthy Individuals by SHERRY CHOW, H.-H, YAN CAI, HAKIM, Iman A, CROWELL, James A, SHAHI, Farah, BROOKS, Chris A, DORR, Robert T, HARA, Yukihiko, ALBERTS, David S

“…Purpose: Green tea and green tea polyphenols have been shown to possess cancer preventive activities in preclinical model systems. In preparation for future…”
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Mitochondrial-mediated disregulation of Ca2+ is a critical determinant of velcade (PS-341/bortezomib) cytotoxicity in myeloma cell lines by LANDOWSKI, Terry H, MEGLI, Christina J, NULLMEYER, Kevin D, LYNCH, Ronald M, DORR, Robert T

“…The proteasome inhibitor bortezomib (also known as PS-341/Velcade) is a dipeptidyl boronic acid that has recently been approved for use in patients with…”
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Characterization of novel diaryl oxazole-based compounds as potential agents to treat pancreatic cancer by Shaw, Arthur Y, Henderson, Meredith C, Flynn, Gary, Samulitis, Betty, Han, Haiyong, Stratton, Steve P, Chow, H-H Sherry, Hurley, Laurence H, Dorr, Robert T

“…A series of diaryl- and fluorenone-based analogs of the lead compound UA-62784 [4-(5-(4-methoxyphenyl)oxazol-2-yl)-9H-fluoren-9-one] was synthesized with the…”
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Imexon induces an oxidative endoplasmic reticulum stress response in pancreatic cancer cells by Sheveleva, Elena V, Landowski, Terry H, Samulitis, Betty K, Bartholomeusz, Geoffrey, Powis, Garth, Dorr, Robert T

“…Oxidative protein folding in the endoplasmic reticulum (ER) requires strict regulation of redox homeostasis. Disruption of the lumenal redox balance induces an…”
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Magnetic Resonance Imaging Identifies Differential Response to Pro-Oxidant Chemotherapy in a Xenograft Model by Landowski, Terry H, Guntle, Gerald P, Zhao, Dezheng, Jagadish, Bhumasamudram, Mash, Eugene A, Dorr, Robert T, Raghunand, Natarajan

“…Abstract Induction of oxidative stress is a key component of cancer therapy. Pro-oxidant drugs have been demonstrated to enhance the efficacy of radiotherapy…”
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UA62784, a novel inhibitor of centromere protein E kinesin-like protein by Henderson, Meredith C, Shaw, Yeng-Jeng Y, Wang, Hong, Han, Haiyong, Hurley, Laurence H, Flynn, Gary, Dorr, Robert T, Von Hoff, Daniel D

“…Pancreatic carcinoma is the fourth leading cause of death from cancer. Novel targets and therapeutic options are needed to aid in the treatment of pancreatic…”
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Ethonafide-induced cytotoxicity is mediated by topoisomerase II inhibition in prostate cancer cells by Pourpak, Alan, Landowski, Terry H, Dorr, Robert T

“…Ethonafide is an anthracene-containing derivative of amonafide that belongs to the azonafide series of anticancer agents. The lack of cross-resistance in…”
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Synthesis, characterization, and anti-melanoma activity of tetra-O-substituted analogs of nordihydroguaiaretic acid by Meyers, Ross O., Lambert, Joshua D., Hajicek, Nicole, Pourpak, Alan, Kalaitzis, John A., Dorr, Robert T.

“…Novel derivatives of nordihydoguaiaretic acid were synthesized and tested for in vitro and in vivo anticancer activity. Synthesis of seven semi-synthetic…”
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Nordihydroguaiaretic acid: hepatotoxicity and detoxification in the mouse by Lambert, Joshua D, Zhao, Dedun, Meyers, Ross O, Kuester, Robert K, Timmermann, Barbara N, Dorr, Robert T

“…Larrea tridentata (Moc & Sess) Cov. (Zygophyllaceae) is an ethnobotanically important plant found in the American Southwest and northern Mexico. Although…”
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Gemcitabine resistant pancreatic cancer cell lines acquire an invasive phenotype with collateral hypersensitivity to histone deacetylase inhibitors by Samulitis, Betty K, Pond, Kelvin W, Pond, Erika, Cress, Anne E, Patel, Hitendra, Wisner, Lee, Patel, Charmi, Dorr, Robert T, Landowski, Terry H

“…Gemcitabine based treatment is currently a standard first line treatment for patients with advanced pancreatic cancer, however overall survival remains poor,…”
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Induction of oxidative stress and apoptosis in myeloma cells by the aziridine-containing agent imexon by Dvorakova, Katerina, Payne, Claire M, Tome, Margaret E, Briehl, Margaret M, McClure, Thomas, Dorr, Robert T

“…Imexon is an iminopyrrolidone derivative that has selective antitumor activity in multiple myeloma. The exact mechanism of imexon action is unknown. In human…”
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New Perspectives on an Old Friend: Optimizing Carboplatin for the Treatment of Solid Tumors by Alberts, David S., Dorr, Robert T.

“…Background. Since its clinical introduction in 1981, carboplatin has proved a feasible alternative to cisplatin for the treatment of many solid tumors,…”
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Design and Synthesis of a Novel DNA−DNA Interstrand Adenine−Guanine Cross-Linking Agent by Zhou, Qun, Duan, Wenhu, Simmons, Denise, Shayo, Yuda, Raymond, Mary Ann, Dorr, Robert T, Hurley, Laurence H

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Melanocortin peptide therapeutics: Historical milestones, clinical studies and commercialization by Hadley, Mac E., Dorr, Robert T.

“…The melanocortins (MCs) are a family of multifunctional peptidergic hormones. Several superpotent, prolonged acting, enzymatically resistant, MC analogs have…”
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Phase 2 study of imexon, a prooxidant molecule, in relapsed and refractory B-cell non-Hodgkin lymphoma by Barr, Paul M., Miller, Thomas P., Friedberg, Jonathan W., Peterson, Derick R., Baran, Andrea M., Herr, Megan, Spier, Catherine M., Cui, Haiyan, Roe, Denise J., Persky, Daniel O., Casulo, Carla, Littleton, Jamie, Schwartz, Mark, Puvvada, Soham, Landowski, Terry H., Rimsza, Lisa M., Dorr, Robert T., Fisher, Richard I., Bernstein, Steven H., Briehl, Margaret M.

“…Lymphoma cells are subject to higher levels of oxidative stress compared with their normal counterparts and may be vulnerable to manipulations of the cellular…”
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Preventing the autophagic survival response by inhibition of calpain enhances the cytotoxic activity of bortezomib in vitro and in vivo by Escalante, Aluvia M., McGrath, Ryan T., Karolak, Matthew R., Dorr, Robert T., Lynch, Ronald M., Landowski, Terry H.

“…Purpose Bortezomib, a first-generation proteasome inhibitor, induces an endoplasmic reticulum (ER) stress response, which ultimately leads to dysregulation of…”
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The diaryl oxazole PC-046 is a tubulin-binding agent with experimental anti-tumor efficacy in hematologic cancers by Landowski, Terry H., Samulitis, Betty K., Dorr, Robert T.

“…Summary Microtubule targeting agents are among the most widely used chemotherapeutics for both solid and hematological malignancies. This study characterizes…”
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Synthesis and Antitumor Activity of Heterocycles Related to Carbendazim by Remers, William A., Iyengar, Bhashyam S., Dorr, Robert T., Wisner, Lee, Bates, Robert B.

“…Three types of compounds were synthesized from carbendazim (1), a benzimidazole derivative (Scheme ). They included a group of esters at N1 prepared by…”
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Anti-tumor activity and mechanism of action for a cyanoaziridine-derivative, AMP423 by Dorr, Robert T., Wisner, Lee, Samulitis, Betty K., Landowski, Terry H., Remers, William A.

“…Purpose Preclinical studies evaluated the anti-tumor activity and mechanism of action of AMP423, a naphthyl derivative of 2-cyanoaziridine-1-carboxamide with…”
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Interaction of Dacarbazine and Imexon, In Vitro and In Vivo, in Human A375 Melanoma Cells by SAMULITIS, Betty K, DORR, Robert T, CHOW, H.-H. Sherry

“…We evaluated mechanisms of interaction between the alkyating agent dacarbazine (DTIC) and the pro-oxidant, imexon, in the human A375 melanoma cell line. The…”
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