Search Results - "Dorr, Patrick"

Rationale of using the dual chemokine receptor CCR2/CCR5 inhibitor cenicriviroc for the treatment of COVID-19 by Files, Daniel Clark, Tacke, Frank, O’Sullivan, Alexandra, Dorr, Patrick, Ferguson, William G., Powderly, William G.

“…Coronavirus Disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has created a global pandemic infecting over 230…”
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Reduced Maximal Inhibition in Phenotypic Susceptibility Assays Indicates that Viral Strains Resistant to the CCR5 Antagonist Maraviroc Utilize Inhibitor-Bound Receptor for Entry by WESTBY, Mike, SMITH-BURCHNELL, Caroline, MORI, Julie, LEWIS, Marilyn, MOSLEY, Nichael, STOCKDALE, Mark, DORR, Patrick, CIARAMELLA, Giuseppe, PERROS, Manos

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Maraviroc (UK-427,857), a Potent, Orally Bioavailable, and Selective Small-Molecule Inhibitor of Chemokine Receptor CCR5 with Broad-Spectrum Anti-Human Immunodeficiency Virus Type 1 Activity by DORR, Patrick, WESTBY, Mike, WEBSTER, Rob, ARMOUR, Duncan, PRICE, David, STAMMEN, Blanda, WOOD, Anthony, PERROS, Manos, DOBBS, Susan, GRIFFIN, Paul, IRVINE, Becky, MACARTNEY, Malcolm, MORI, Julie, RICKETT, Graham, SMITH-BURCHNELL, Caroline, NAPIER, Carolyn

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Diversity of CFTR variants across ancestries characterized using 454,727 UK biobank whole exome sequences by Ideozu, Justin E, Liu, Mengzhen, Riley-Gillis, Bridget M, Paladugu, Sri R, Rahimov, Fedik, Krishnan, Preethi, Tripathi, Rakesh, Dorr, Patrick, Levy, Hara, Singh, Ashvani, Waring, Jeffrey F, Vasanthakumar, Aparna

“…Limited understanding of the diversity of variants in the cystic fibrosis transmembrane conductance regulator (CFTR) gene across ancestries hampers efforts to…”
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Biomarkers for the clinical development of antiviral therapies by Ng, Teresa I., Dorr, Patrick K., Krishnan, Preethi, Cohen, Daniel E., Rhee, Susan, Wang, Stanley X., Ruzek, Melanie C., Mensa, Federico J., Kati, Warren M.

“…With the morbidity and mortality associated with the COVID‐19 pandemic that we are witnessing this year, the risks posed by emerging viral diseases to global…”
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An Imidazopiperidine Series of CCR5 Antagonists for the Treatment of HIV: The Discovery of N-{(1S)-1-(3-Fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide (PF-232798) by Stupple, Paul A, Batchelor, David V, Corless, Martin, Dorr, Patrick K, Ellis, David, Fenwick, David R, Galan, Sébastien R. G, Jones, Rhys M, Mason, Helen J, Middleton, Donald S, Perros, Manos, Perruccio, Francesca, Platts, Michelle Y, Pryde, David C, Rodrigues, Deborah, Smith, Nicholas N, Stephenson, Peter T, Webster, Robert, Westby, Mike, Wood, Anthony

“…Preventing entry of HIV into human host cells has emerged as an attractive approach to controlling viral replication. Maraviroc 1 is an approved antagonist of…”
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Novel Small-Molecule Inhibitors of RNA Polymerase III by Wu, Liping, Pan, Jing, Thoroddsen, Vala, Wysong, Deborah R, Blackman, Ronald K, Bulawa, Christine E, Gould, Alexandra E, Ocain, Timothy D, Dick, Lawrence R, Errada, Patrick, Dorr, Patrick K, Parkinson, Tanya, Wood, Tony, Kornitzer, Daniel, Weissman, Ziva, Willis, Ian M, McGovern, Karen

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Real‐world safety and effectiveness of ombitasvir/paritaprevir/ritonavir ± dasabuvir ± ribavirin in hepatitis C virus genotype 1‐ and 4‐infected patients with diverse comorbidities and comedications: A pooled analysis of post‐marketing observational studies from 13 countries by Ferenci, Peter, Bourgeois, Stefan, Buggisch, Peter, Norris, Suzanne, Curescu, Manuela, Larrey, Dominique, Marra, Fiona, Kleine, Henning, Dorr, Patrick, Charafeddine, Mariem, Crown, Eric, Bondin, Mark, Back, David, Flisiak, Robert

“…Summary Ombitasvir/paritaprevir/ritonavir ± dasabuvir ± ribavirin (OBV/PTV/r ± DSV ± RBV) regimens show high efficacy and good tolerability in clinical trials…”
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Susceptibility of HIV type 2 primary isolates to CCR5 and CXCR4 monoclonal antibodies, ligands, and small molecule inhibitors by Espirito-Santo, Maria, Santos-Costa, Quirina, Calado, Marta, Dorr, Patrick, Azevedo-Pereira, J Miguel

“…Human immunodeficiency virus (HIV) entry into susceptible cells involves the interaction between viral envelope glycoproteins with CD4 and a chemokine receptor…”
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Inhibition of CCR5-mediated infection by diverse R5 and R5X4 HIV and SIV isolates using novel small molecule inhibitors of CCR5: Effects of viral diversity, target cell and receptor density by Willey, Samantha, Peters, Paul J., Sullivan, W. Matthew, Dorr, Patrick, Perros, Manos, Clapham, Paul R.

“…Highly active anti-retroviral therapy (HAART) has been very effective in reducing viral loads in human immunodeficiency virus (HIV)-1 patients. However,…”
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CCR5 pharmacology methodologies and associated applications by Mansfield, Roy, Able, Sarah, Griffin, Paul, Irvine, Becky, James, Ian, Macartney, Malcolm, Miller, Ken, Mills, James, Napier, Carolyn, Navratilova, Iva, Perros, Manos, Rickett, Graham, Root, Harriet, van der Ryst, Elna, Westby, Mike, Dorr, Patrick

“…The G protein-coupled chemokine (C-C motif) receptor, CCR5, was originally characterized as a protein responding functionally to a number of CC chemokines. As…”
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Plasma progesterone levels in human pregnancy a study by competitive protein binding by Dorr, Patrick

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Can the World Afford Autistic Spectrum Disorder? Nonverbal Communication, Asperger Syndrome and the Interbrain by Tantum, Digby

“…Dorr reviews Can the World Afford Autistic Spectrum Disorder? Nonverbal Communication, Asperger Syndrome and the Interbrain by Digby Tantam…”
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New instruments for paracervical and pudendal nerve blocks by Dorr, P

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Oxytocin-induced Water Intoxication by Dorr, P

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Preparing a Company for Property Book Split and Deployment by Chang, Sungkuyn "Eddie", Dorr, Patrick, Shelton, Christina

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The AMT for Fiduciaries: An Overlooked Debacle of TRA '86 by Dorr, Patrick B

“…The author focuses on avoiding the problems that arise in allocating AMT among a fiduciary and its beneficiaries…”
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"Crane After Tufts": Still Some Unanswered Questions by Dorr, Patrick B, Lacy, Melvin E

“…The determination of the transferee's basis in property acquired having a fair market value less than the nonrecourse indebtedness secured by the property, an…”
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PELVIC LYMPHOCYST by QUINN, L J, DORR, P

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