Search Results - "Dorow, Donna"

High-contrast PET of melanoma using (18)F-MEL050, a selective probe for melanin with predominantly renal clearance by Denoyer, Delphine, Greguric, Ivan, Roselt, Peter, Neels, Oliver C, Aide, Nicolas, Taylor, Stephen R, Katsifis, Andrew, Dorow, Donna S, Hicks, Rodney J

“…The aim of this study was to evaluate the novel probe (18)F-6-fluoro-N-[2-(diethylamino)ethyl] pyridine-3-carboxamide ((18)F-MEL050) for the imaging of primary…”
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Imaging of tumor hypoxia with [124I]IAZA in comparison with [18F]FMISO and [18F]FAZA--first small animal PET results by Reischl, Gerald, Dorow, Donna S, Cullinane, Carleen, Katsifis, Andrew, Roselt, Peter, Binns, David, Hicks, Rodney J

“…This study was performed to compare the 2-nitroimidazole derivatives [124I]IAZA, [18F]FAZA and well known [18F]FMISO in visualization of tumor hypoxia in a…”
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Differential (18)F-FDG and 3'-deoxy-3'-(18)F-fluorothymidine PET responses to pharmacologic inhibition of the c-MET receptor in preclinical tumor models by Cullinane, Carleen, Dorow, Donna S, Jackson, Susan, Solomon, Benjamin, Bogatyreva, Ekaterina, Binns, David, Young, Richard, Arango, Maria E, Christensen, James G, McArthur, Grant A, Hicks, Rodney J

“…The ability of PET to image functional changes in tumors is increasingly being used to evaluate response and predict clinical benefit to conventional and novel…”
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Discovery of [18F]N-(2-(Diethylamino)ethyl)-6-fluoronicotinamide: A Melanoma Positron Emission Tomography Imaging Radiotracer with High Tumor to Body Contrast Ratio and Rapid Renal Clearance by Greguric, Ivan, Taylor, Stephen R, Denoyer, Delphine, Ballantyne, Patrice, Berghofer, Paula, Roselt, Peter, Pham, Tien Q, Mattner, Filomena, Bourdier, Thomas, Neels, Oliver C, Dorow, Donna S, Loc’h, Christian, Hicks, Rodney J, Katsifis, Andrew

“…The high melanoma uptake and rapid body clearance displayed by our series of [123I]iodonicotinamides prompted the development of…”
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Radiosynthesis and Biological Evaluation of l- and d-S-(3-[18F]Fluoropropyl)homocysteine for Tumor Imaging Using Positron Emission Tomography by Bourdier, Thomas, Shepherd, Rachael, Berghofer, Paula, Jackson, Timothy, Fookes, Christopher J. R, Denoyer, Delphine, Dorow, Donna S, Greguric, Ivan, Gregoire, Marie-Claude, Hicks, Rodney J, Katsifis, Andrew

“…Interest in radiolabeled amino acids for metabolic imaging of cancer and limitations with [11C]methionine has prompted the development of a new 18F-labeled…”
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An in vivo tumor model exploiting metabolic response as a biomarker for targeted drug development by CULLINANE, Carleen, DOROW, Donna S, KANSARA, Maya, CONUS, Nelly, BINNS, David, HICKS, Rodney J, ASHMAN, Leonie K, MCARTHUR, Grant A, THOMAS, David M

“…In vivo models that recapitulate oncogene-dependent tumorigenesis will greatly facilitate development of molecularly targeted anticancer therapies. We have…”
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Kainate Receptor Activation Induces Mixed Lineage Kinase-mediated Cellular Signaling Cascades via Post-synaptic Density Protein 95 by Savinainen, Anneli, Garcia, Elizabeth P., Dorow, Donna, Marshall, John, Liu, Ya Fang

“…Kainate receptor glutamate receptor 6 (GluR6) subunit-deficient and c-Jun N-terminal kinase 3 (JNK3)-null mice share similar phenotypes including resistance to…”
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18F-FLT PET as a surrogate marker of drug efficacy during mTOR inhibition by everolimus in a preclinical cisplatin-resistant ovarian tumor model by Aide, Nicolas, Kinross, Kathryn, Cullinane, Carleen, Roselt, Peter, Waldeck, Kelly, Neels, Oliver, Dorow, Donna, McArthur, Grant, Hicks, Rodney J

“…Targeting the mammalian target of rapamycin (mTOR) pathway is a potential means of overcoming cisplatin resistance in ovarian cancer patients. Because mTOR…”
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Activation of MLK2-mediated Signaling Cascades by Polyglutamine-expanded Huntingtin by Liu, Ya Fang, Dorow, Donna, Marshall, John

“…We previously reported that expression of polyglutamine-expanded huntingtin induces apoptosis via c-Jun amino-terminal kinase (JNK) activation in HN33 cells…”
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Multi-tracer small animal PET imaging of the tumour response to the novel pan-Erb-B inhibitor CI-1033 by Dorow, Donna S, Cullinane, Carleen, Conus, Nelly, Roselt, Peter, Binns, David, McCarthy, Timothy J, McArthur, Grant A, Hicks, Rodney J

“…This study was designed as "proof of concept" for a drug development model utilising multi-tracer serial small animal PET imaging to characterise tumour…”
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Mixed Lineage Kinase 2 Interacts with Clathrin and Influences Clathrin-coated Vesicle Trafficking by Akbarzadeh, Shiva, Ji, Hong, Frecklington, David, Marmy-Conus, Nelly, Mok, Yee-Foong, Bowes, Leanne, Devereux, Lisa, Linsenmeyer, Martha, Simpson, Richard J., Dorow, Donna S.

“…Mixed lineage kinase 2 (MLK2) is a protein kinase that signals in the stress-activated Jun N-terminal kinase signal transduction pathway. We used…”
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Activated JNK Phosphorylates the C-terminal Domain of MLK2 That Is Required for MLK2-induced Apoptosis by Phelan, David R., Price, Gareth, Liu, Ya Fang, Dorow, Donna S.

“…MAP kinase signaling pathways are important mediators of cellular responses to a wide variety of stimuli. Signals pass along these pathways via kinase cascades…”
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Cancer proteomics: from signaling networks to tumor markers by Simpson, Richard J, Dorow, Donna S

“…Along with the great strides that have been made towards understanding cancer, has come a realization of the complexity of molecular events that lead to…”
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18 F-FLT PET as a Surrogate Marker of Drug Efficacy During mTOR Inhibition by Everolimus in a Preclinical Cisplatin-Resistant Ovarian Tumor Model by Aide, Nicolas, Kinross, Kathryn, Cullinane, Carleen, Roselt, Peter, Waldeck, Kelly, Neels, Oliver, Dorow, Donna, McArthur, Grant, Hicks, Rodney J.

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sup 18^F-FLT PET as a Surrogate Marker of Drug Efficacy During mTOR Inhibition by Everolimus in a Preclinical Cisplatin-Resistant Ovarian Tumor Model by Aide, Nicolas, Kinross, Kathryn, Cullinane, Carleen, Roselt, Peter, Waldeck, Kelly, Neels, Oliver, Dorow, Donna, McArthur, Grant, Hicks, Rodney J

“…Targeting the mammalian target of rapamycin (mTOR) pathway is a potential means of overcoming cisplatin resistance in ovarian cancer patients. Because mTOR…”
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Differential ^sup 18^F-FDG and 3'-Deoxy-3'-^sup 18^F-Fluorothymidine PET Responses to Pharmacologic Inhibition of the c-MET Receptor in Preclinical Tumor Models by Cullinane, Carleen, Dorow, Donna S, Jackson, Susan, Solomon, Benjamin, Bogatyreva, Ekaterina, Binns, David, Young, Richard, Arango, Maria E, Christensen, James G, McArthur, Grant A, Hicks, Rodney J

“…The ability of PET to image functional changes in tumors is increasingly being used to evaluate response and predict clinical benefit to conventional and novel…”
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Differential 18 F-FDG and 3′-Deoxy-3′- 18 F-Fluorothymidine PET Responses to Pharmacologic Inhibition of the c-MET Receptor in Preclinical Tumor Models by Cullinane, Carleen, Dorow, Donna S., Jackson, Susan, Solomon, Benjamin, Bogatyreva, Ekaterina, Binns, David, Young, Richard, Arango, Maria E., Christensen, James G., McArthur, Grant A., Hicks, Rodney J.

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Abstract 5236: Intermittent anti-angiogenic therapy with sunitinib in a murine xenograft model monitored by dynamic contrast enhanced ultra high frequency sonography by Hunnam, Titaina C. Potdevin, Tuthill, Theresa A., Dorow, Donna S., Cullinane, Carleen, McCarthy, Timothy J., Hicks, Rodney J.

“…Sunitinib is an orally bio-available small-molecule inhibitor that targets multiple pro-angiogenic receptor tyrosine kinases including VEGFR, PDGFR, c-KIT,…”
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Fabrication of stable packed capillary reversed-phase columns for protein structural analysis by Tong, D, Moritz, R L, Eddes, J S, Reid, G E, Rasmussen, R K, Dorow, D S, Simpson, R J

“…Capillary column (< or = 320-micron ID) liquid chromatography is an essential tool for the separation and concentration of low-picomole amounts of proteins and…”
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Differential 18F-FDG and 3'-Deoxy-3'-18F-Fluorothymidine PET Responses to Pharmacologic Inhibition of the c-MET Receptor in Preclinical Tumor Models by Cullinane, Carleen, Dorow, Donna S, Jackson, Susan, Solomon, Benjamin, Bogatyreva, Ekaterina, Binns, David, Young, Richard, Arango, Maria E, Christensen, James G, McArthur, Grant A, Hicks, Rodney J

“…The ability of PET to image functional changes in tumors is increasingly being used to evaluate response and predict clinical benefit to conventional and novel…”
Get full text