Effect of Local Application of Superoxide Dismutase on Dielectric Parameters of Cooled Skin in Rats

Effect of Local Application of Superoxide Dismutase on Dielectric Parameters of Cooled Skin in Rats

The effect of on Changes in dielectric parameters of the skin (modulus of complex dielectric permittivity |ε| and dielectric loss tangent tgδ) were studied on rats with local surface contact cooling followed by treatment with various cream formulations. Addition of antioxidant superoxide dismutase (...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine Vol. 146; no. 5; pp. 588 - 590
Main Authors: Paramonov, B. A, Turkovski, I. I, Doroshkevich, O. S, Taranova, V. N, Pomorski, K. P
Format: Journal Article
Language:English
Published: Boston Boston : Springer US 01-11-2008
Springer US
Springer Nature B.V
Subjects:
Animals
antioxidants
Biomedical and Life Sciences
Biomedicine
Cell Biology
cooling
frostbite
Frostbite - chemically induced
Frostbite - drug therapy
Frostbite - metabolism
Internal Medicine
Laboratory Medicine
Male
Pathology
Pharmacology and Toxicology
Rats
Skin - drug effects
Skin - metabolism
superoxide dismutase
Superoxide Dismutase - administration & dosage
Superoxide Dismutase - pharmacology
UHF dielectrometry
Wound Healing - drug effects
frostbite
cooling
UHF dielectrometry
antioxidants
superoxide dismutase
Online Access:Get full text
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Summary:The effect of on Changes in dielectric parameters of the skin (modulus of complex dielectric permittivity |ε| and dielectric loss tangent tgδ) were studied on rats with local surface contact cooling followed by treatment with various cream formulations. Addition of antioxidant superoxide dismutase (SOD) to the cream significantly prevented the shifts in these parameters, which attested to less pronounced changes in the water balance in SOD-treated skin. Application of SOD during the early terms after cooling accelerated wound healing. Histological examination performed on posttraumatic day 60 revealed better integrity of the skin structures (hair follicle, sweat and sebaceous gland), which indicates ability of SOD to prevent and ameliorate the degree of coldinduced damage in the skin.
Bibliography:http://dx.doi.org/10.1007/s10517-009-0352-2
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-009-0352-2