Search Results - "Dorne, JLCM"

Human variability in CYP3A4 metabolism and CYP3A4-related uncertainty factors for risk assessment by Dorne, J.L.C.M, Walton, K, Renwick, A.G

“…CYP3A4 constitutes the major liver cytochrome P450 isoenzyme and is responsible for the oxidation of more than 50% of all known drugs. Human variability in…”
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Human variability in polymorphic CYP2D6 metabolism: is the kinetic default uncertainty factor adequate? by Dorne, J.L.C.M, Walton, K, Slob, W, Renwick, A.G

“…Human variability in the kinetics of CYP2D6 substrates has been quantified using a database of compounds metabolised extensively (>60%) by this polymorphic…”
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Current EU research activities on combined exposure to multiple chemicals by Bopp, Stephanie K., Barouki, Robert, Brack, Werner, Dalla Costa, Silvia, Dorne, Jean-Lou C.M., Drakvik, Paula E., Faust, Michael, Karjalainen, Tuomo K., Kephalopoulos, Stylianos, van Klaveren, Jacob, Kolossa-Gehring, Marike, Kortenkamp, Andreas, Lebret, Erik, Lettieri, Teresa, Nørager, Sofie, Rüegg, Joëlle, Tarazona, Jose V., Trier, Xenia, van de Water, Bob, van Gils, Jos, Bergman, Åke

“…Humans and wildlife are exposed to an intractably large number of different combinations of chemicals via food, water, air, consumer products, and other media…”
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Human and animal health risk assessments of chemicals in the food chain: Comparative aspects and future perspectives by Dorne, J.L.C.M., Fink-Gremmels, J.

“…Chemicals from anthropogenic and natural origins enter animal feed, human food and water either as undesirable contaminants or as part of the components of a…”
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Risk assessment of coccidostatics during feed cross-contamination: Animal and human health aspects by Dorne, J.L.C.M., Fernández-Cruz, M.L., Bertelsen, U., Renshaw, D.W., Peltonen, K., Anadon, A., Feil, A., Sanders, P., Wester, P., Fink-Gremmels, J.

“…Coccidiosis, an intestinal plasmodium infection, is a major infectious disease in poultry and rabbits. Eleven different coccidiostats are licensed in the EU…”
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Metabolism, variability and risk assessment by Dorne, J.L.C.M

“…Abstract For non-genotoxic carcinogens, “thresholded toxicants”, Acceptable/Tolerable Daily Intakes (ADI/TDI) represent a level of exposure “without…”
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The Refinement of Uncertainty/Safety Factors in Risk Assessment by the Incorporation of Data on Toxicokinetic Variability in Humans by Dorne, J. L. C. M., Renwick, A. G.

“…The derivation of safe levels of exposure in humans for compounds that are assumed to cause threshold toxicity has relied on the application of a 100-fold…”
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Human variability in xenobiotic metabolism and pathway-related uncertainty factors for chemical risk assessment: a review by Dorne, J.L.C.M., Walton, K., Renwick, A.G.

“…This review provides an account of recent developments arising from a database that defined human variability in phase I metabolism (CYP1A2, CYP2A6, CYP2C9,…”
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Human and environmental risk assessment of pharmaceuticals: differences, similarities, lessons from toxicology by Dorne, J. L. C. M, Skinner, L, Frampton, G. K, Spurgeon, D. J, Ragas, A. M. J

“…The presence of human and veterinary pharmaceuticals in the environment has caused increasing concern due their effects on ecological receptors. Improving the…”
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Meta-analysis of human toxicokinetic data: An innovative Bayesian approach and its application in human risk assessment by Dorne, Jean Lou C.M., Amzal, Billy

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Demographic data in asthma clinical trials: A systematic review with implications for generalizing trial findings and tackling health disparities by Frampton, Geoff K., Shepherd, Jonathan, Dorne, Jean-Lou C.M.

“…The prevalence of asthma, and the morbidity, adverse events, mortality and healthcare utilisation of asthmatic patients vary widely among racial/ethnic and…”
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Human variability in hepatic and renal elimination: implications for risk assessment by Dorne, J. L. C. M.

“…Hepatic metabolism and renal excretion constitute the main routes of xenobiotic elimination in humans. Improving human risk assessment for threshold…”
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Editorial: Increasing robustness, transparency and openness of scientific assessments by Hardy, A, Dorne, JLCM, Aiassa, E, Alexander, J, Bottex, B, Chaudhry, Q, Germini, A, Nørrung, B, Schlatter, J, Verloo, D, Robinson, T

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Species-specific uncertainty factors for compounds eliminated principally by renal excretion in humans by Walton, K, Dorne, J.L.C.M, Renwick, A.G

“…An uncertainty factor of 100 is used to derive health-based guidance values for human intakes of chemicals based on data from studies in animals. The 100-fold…”
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Trends in human risk assessment of pharmaceuticals by Dorne, J. L. C. M, Ragas, A. M. J, Frampton, G. K, Spurgeon, D. S, Lewis, D. F

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Uncertainty factors for chemical risk assessment: human variability in the pharmacokinetics of CYP1A2 probe substrates by Dorne, J.L.C.M, Walton, K, Renwick, A.G

“…A 100-fold uncertainty factor is used to derive acceptable daily intakes for compounds causing thresholded toxicity. The 10-fold factor for human variability…”
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Impact of inter-individual differences in drug metabolism and pharmacokinetics on safety evaluation by Dorne, J.L.C.M.

“…Safety evaluation aims to assess the dose–response relationship to determine a dose/level of exposure for food contaminants below which no deleterious effect…”
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Human variability in the renal elimination of foreign compounds and renal excretion-related uncertainty factors for risk assessment by Dorne, J.L.C.M., Walton, K., Renwick, A.G.

“…Renal excretion is an important route of elimination for xenobiotics and three processes determine the renal clearance of a compound [glomerular filtration…”
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Human variability for metabolic pathways with limited data (CYP2A6, CYP2C9, CYP2E1, ADH, esterases, glycine and sulphate conjugation) by Dorne, J.L.C.M, Walton, K, Renwick, A.G

“…Human variability in the kinetics of a number of phase I (CYP2A6, CYP2C9, CYP2E1, alcohol dehydrogenase and hydrolysis) and phase II enzymes (glycine and…”
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Polymorphic CYP2C19 and N-acetylation: human variability in kinetics and pathway-related uncertainty factors by Dorne, J.L.C.M, Walton, K, Renwick, A.G

“…CYP2C19-mediated oxidation and N-acetylation constitute major phase I and phase II polymorphic pathways of xenobiotic metabolism in humans. Analysis of human…”
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