Search Results - "Dorn, Gerald W. II"

A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance by Hammerling, Babette C., Najor, Rita H., Cortez, Melissa Q., Shires, Sarah E., Leon, Leonardo J., Gonzalez, Eileen R., Boassa, Daniela, Phan, Sébastien, Thor, Andrea, Jimenez, Rebecca E., Li, Hong, Kitsis, Richard N., Dorn, Gerald W., Sadoshima, Junichi, Ellisman, Mark H., Gustafsson, Åsa B.

“…Damaged mitochondria pose a lethal threat to cells that necessitates their prompt removal. The currently recognized mechanism for disposal of mitochondria is…”
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Mitochondrial Dynamism and Cardiac Fate: A Personal Perspective by Dorn, Gerald W., II

“…Defects in mitochondrial biogenesis are well known to contribute to cardiac dysfunction. By contrast, mechanistic details of essential homeostatic mechanisms…”
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Bax regulates primary necrosis through mitochondrial dynamics by Whelan, Russell S, Konstantinidis, Klitos, Wei, An-Chi, Chen, Yun, Reyna, Denis E, Jha, Saurabh, Yang, Ying, Calvert, John W, Lindsten, Tullia, Thompson, Craig B, Crow, Michael T, Gavathiotis, Evripidis, Dorn, Gerald W. II, O'Rourke, Brian, Kitsis, Richard N

“…The defining event in apoptosis is mitochondrial outer membrane permeabilization (MOMP), allowing apoptogen release. In contrast, the triggering event in…”
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Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration by Joshi, Amit U., Minhas, Paras S., Liddelow, Shane A., Haileselassie, Bereketeab, Andreasson, Katrin I., Dorn, Gerald W., Mochly-Rosen, Daria

“…In neurodegenerative diseases, debris of dead neurons are thought to trigger glia-mediated neuroinflammation, thus increasing neuronal death. Here we show that…”
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Trans-mitochondrial coordination of cristae at regulated membrane junctions by Picard, Martin, McManus, Meagan J., Csordás, György, Várnai, Péter, Dorn II, Gerald W., Williams, Dewight, Hajnóczky, György, Wallace, Douglas C.

“…Reminiscent of bacterial quorum sensing, mammalian mitochondria participate in inter-organelle communication. However, physical structures that enhance or…”
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Targeting cyclophilin D and the mitochondrial permeability transition enhances β-cell survival and prevents diabetes in Pdx1 deficiency by Fujimoto, Kei, Chen, Yun, Polonsky, Kenneth S, Dorn, Gerald W. II

“…Mutations of the pancreatic duodenal homeobox gene-1, Pdx1, cause heritable diabetes in humans and mice. A central abnormality with Pdx1 deficiency is…”
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Loss-of-function DNA sequence variant in the CLCNKA chloride channel implicates the cardio-renal axis in interindividual heart failure risk variation by Cappola, Thomas P, Matkovich, Scot J, Wang, Wei, van Booven, Derek, Li, Mingyao, Wang, Xuexia, Qu, Liming, Sweitzer, Nancy K, Fang, James C, Reilly, Muredach P, Hakonarson, Hakon, Nerbonne, Jeanne M, Dorn, Gerald W. II

“…Common heart failure has a strong undefined heritable component. Two recent independent cardiovascular SNP array studies identified a common SNP at 1p36 in…”
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Unrestrained erythroblast development in Nix⁻/⁻ mice reveals a mechanism for apoptotic modulation of erythropoiesis by Diwan, Abhinav, Koesters, Andrew G, Odley, Amy M, Pushkaran, Suvarnamala, Baines, Christopher P, Spike, Benjamin T, Daria, Diedre, Jegga, Anil G, Geiger, Hartmut, Aronow, Bruce J, Molkentin, Jeffery D, Macleod, Kay F, Kalfa, Theodosia A, Dorn, Gerald W. II

“…Normal production of RBCs requires that the antiapoptotic protein Bcl-xl be induced at end stages of differentiation in response to erythropoietin (Epo)…”
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Human Mutation in the Anti-apoptotic Heat Shock Protein 20 Abrogates Its Cardioprotective Effects by Nicolaou, Persoulla, Knöll, Ralph, Haghighi, Kobra, Fan, Guo-Chang, Dorn, Gerald W., Hasenfuß, Gerd, Kranias, Evangelia G.

“…The small heat shock protein Hsp20 protects cardiomyocytes against apoptosis, and phosphorylation at its Ser16 site enhances its cardioprotection. To determine…”
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human phospholamban promoter polymorphism in dilated cardiomyopathy alters transcriptional regulation by glucocorticoids by Haghighi, Kobra, Chen, Guoli, Sato, Yoji, Fan, Guo-Chang, He, Suiwen, Kolokathis, Fotis, Pater, Luke, Paraskevaidis, Ioannis, Jones, W. Keith, Dorn II, Gerald W, Th. Kremastinos, Dimitrios, Kranias, Evangelia G

“…Depressed calcium handling by the sarcoplasmic reticulum (SR) Ca-ATPase and its regulator phospholamban (PLN) is a key characteristic of human and experimental…”
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Activating mitofusins interrupts mitochondrial degeneration and delays disease progression in SOD1 mutant amyotrophic lateral sclerosis by Dang, Xiawei, Zhang, Lihong, Franco, Antonietta, Dorn II, Gerald W

“…Abstract Mitochondrial involvement in neurodegenerative diseases is widespread and multifactorial. Targeting mitochondrial pathology is therefore of interest…”
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Myocardial Oxygen Consumption Change Predicts Left Ventricular Relaxation Improvement in Obese Humans After Weight Loss by Lin, C. Huie, Kurup, Suraj, Herrero, Pilar, Schechtman, Kenneth B., Eagon, J. Christopher, Klein, Samuel, Dávila‐Román, Víctor G., Stein, Richard I., Dorn‐II, Gerald W., Gropler, Robert J., Waggoner, Alan D., Peterson, Linda R.

“…Obesity adversely affects myocardial metabolism, efficiency, and diastolic function. Our objective was to determine whether weight loss can ameliorate…”
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MicroRNA-133 controls cardiac hypertrophy by Peschle, Cesare, Condorelli, Gianluigi, Carè, Alessandra, Catalucci, Daniele, Felicetti, Federica, Bonci, Désirée, Addario, Antonio, Gallo, Paolo, Bang, Marie-Louise, Segnalini, Patrizia, Gu, Yusu, Dalton, Nancy D, Elia, Leonardo, Latronico, Michael V G, Høydal, Morten, Autore, Camillo, Russo, Matteo A, Dorn, Gerald W, Ellingsen, Øyvind, Ruiz-Lozano, Pilar, Peterson, Kirk L, Croce, Carlo M

“…Growing evidence indicates that microRNAs (miRNAs or miRs) are involved in basic cell functions and oncogenesis. Here we report that miR-133 has a critical…”
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A GRK5 polymorphism that inhibits β-adrenergic receptor signaling is protective in heart failure by Martini, Jeffrey S, Koch, Walter J, Sparks, Li, Kardia, Sharon L R, Dorn II, Gerald W, Spertus, John A, Parekh, Rohan R, Matkovich, Scot J, Kelly, Reagan J, Liggett, Stephen B, Cresci, Sharon, Hahn, Harvey S, Diwan, Abhinav, Syed, Faisal M

“…β-adrenergic receptor (βAR) blockade is a standard therapy for cardiac failure and ischemia. G protein–coupled receptor kinases (GRKs) desensitize βARs,…”
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The rationale for cardiomyocyte resuscitation in myocardial salvage by Dorn II, Gerald W., Diwan, Abhinav

“…Clinical heart failure results from the cumulative loss of functioning myocardium from any cause. At the cellular level, cardiac myocytes die from three…”
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Protein Kinase D Links Gq-coupled Receptors to cAMP Response Element-binding Protein (CREB)-Ser133 Phosphorylation in the Heart by Ozgen, Nazira, Obreztchikova, Maria, Guo, Jianfen, Elouardighi, Hasnae, Dorn, Gerald W., Wilson, Brenda A., Steinberg, Susan F.

“…Many growth regulatory stimuli promote cAMP response element-binding protein (CREB) Ser133 phosphorylation, but the physiologically relevant CREB-Ser133…”
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Myeloid-specific GPCR kinase-2 negatively regulates NF-κB1p105-ERK pathway and limits endotoxemic shock in mice by Patial, Sonika, Saini, Yogesh, Parvataneni, Sitaram, Appledorn, Daniel M., Dorn II, Gerald W., LaPres, John J., Amalfitano, Andrea, Senagore, Patricia, Parameswaran, Narayanan

“…G‐protein‐coupled receptor kinase 2 (GRK2) is a member of a kinase family originally discovered for its role in the phosphorylation and desensitization of…”
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Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling by Dhingra, Rimpy, Margulets, Victoria, Chowdhury, Subir Roy, Thliveris, James, Jassal, Davinder, Fernyhough, Paul, Dorn, 2nd, Gerald W, Kirshenbaum, Lorrie A

“…Significance We provide new, exciting evidence for a previously unidentified signaling pathway that mechanistically links mitochondrial respiratory chain…”
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Restoring mitofusin balance prevents axonal degeneration in a Charcot-Marie-Tooth type 2A model by Zhou, Yueqin, Carmona, Sharon, Muhammad, A K M G, Bell, Shaughn, Landeros, Jesse, Vazquez, Michael, Ho, Ritchie, Franco, Antonietta, Lu, Bin, Dorn, 2nd, Gerald W, Wang, Shaomei, Lutz, Cathleen M, Baloh, Robert H

“…Mitofusin-2 (MFN2) is a mitochondrial outer-membrane protein that plays a pivotal role in mitochondrial dynamics in most tissues, yet mutations in MFN2, which…”
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Nix Is Critical to Two Distinct Phases of Mitophagy, Reactive Oxygen Species-mediated Autophagy Induction and Parkin-Ubiquitin-p62-mediated Mitochondrial Priming by Ding, Wen-Xing, Ni, Hong-Min, Li, Min, Liao, Yong, Chen, Xiaoyun, Stolz, Donna B., Dorn, Gerald W., Yin, Xiao-Ming

“…Damaged mitochondria can be eliminated by autophagy, i.e. mitophagy, which is important for cellular homeostasis and cell survival. Despite the fact that a…”
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