Search Results - "Doria, Maria Luísa"
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Epithelial ovarian carcinoma diagnosis by desorption electrospray ionization mass spectrometry imaging
Published in Scientific reports (15-12-2016)“…Ovarian cancer is highly prevalent among European women, and is the leading cause of gynaecological cancer death. Current histopathological diagnoses of tumour…”
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Journal Article -
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Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids
Published in Cell (25-06-2020)“…Oncogenic transformation is associated with profound changes in cellular metabolism, but whether tracking these can improve disease stratification or influence…”
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Journal Article -
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Targeted Desorption Electrospray Ionization Mass Spectrometry Imaging for Drug Distribution, Toxicity, and Tissue Classification Studies
Published in Metabolites (01-03-2023)“…With increased use of mass spectrometry imaging (MSI) in support of pharmaceutical research and development, there are opportunities to develop analytical…”
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Journal Article -
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Extracellular vesicles as a promising source of lipid biomarkers for breast cancer detection in blood plasma
Published in Journal of extracellular vesicles (01-03-2024)“…Extracellular vesicles (EVs), including exosomes and microvesicles, mediate intercellular communication in cancer, from development to metastasis. EV‐based…”
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Journal Article -
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LXR activation by GW3965 alters fat tissue distribution and adipose tissue inflammation in ob/ob female mice[S]
Published in Journal of lipid research (01-05-2013)“…To investigate the role of liver X receptor (LXR) in adipose tissue metabolism during obesity, ob/ob mice were treated for 5 weeks with the synthetic LXR…”
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Journal Article -
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Metabolism and disposition of zamicastat in rats
Published in Xenobiotica (10-10-2024)“…The metabolism and disposition of zamicastat, a reversible dopamine β-hydroxylase (DβH) inhibitor, developed for treatment of Pulmonary Arterial Hypertension…”
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Journal Article -
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Development of spatially-resolved lipidomic methods for cancer diagnostics
Published 01-01-2017“…Ovarian cancer is the fifth most common cancer among women, with a great demand for the development of diagnostics towards improved performance, shorter…”
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Dissertation -
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Enhanced triacylglycerol catabolism by carboxylesterase 1 promotes aggressive colorectal carcinoma
Published in The Journal of clinical investigation (01-06-2021)“…The ability to adapt to low-nutrient microenvironments is essential for tumor cell survival and progression in solid cancers, such as colorectal carcinoma…”
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Journal Article -
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Phospholipid Profile of Different Breast Cancer Cell Lines
Published 01-01-2011“…Breast cancer is the leading cause of cancer-related death in women. Altered cellular functions of cancer cells lead to uncontrolled cellular growth and…”
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Dissertation