Search Results - "Dorfman, Mauricio"

Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility by Valdearcos, Martin, Douglass, John D., Robblee, Megan M., Dorfman, Mauricio D., Stifler, Daniel R., Bennett, Mariko L., Gerritse, Irene, Fasnacht, Rachael, Barres, Ben A., Thaler, Joshua P., Koliwad, Suneil K.

“…Dietary excess triggers accumulation of pro-inflammatory microglia in the mediobasal hypothalamus (MBH), but the components of this microgliosis and its…”
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Hypothalamic inflammation and gliosis in obesity by Dorfman, Mauricio D., Thaler, Joshua P.

“…Hypothalamic inflammation and gliosis are recently discovered mechanisms that may contribute to obesity pathogenesis. Current research in this area suggests…”
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Glia: silent partners in energy homeostasis and obesity pathogenesis by Douglass, John D., Dorfman, Mauricio D., Thaler, Joshua P.

“…Body weight stability requires homeostatic regulation to balance energy intake and energy expenditure. Research on this system and how it is affected by…”
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Hypothalamic Inflammation: Marker or Mechanism of Obesity Pathogenesis? by THALER, Joshua P, GUYENET, Stephan J, DORFMAN, Mauricio D, WISSE, Brent E, SCHWARTZ, Michael W

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Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice by Dorfman, Mauricio D., Krull, Jordan E., Douglass, John D., Fasnacht, Rachael, Lara-Lince, Fernando, Meek, Thomas H., Shi, Xiaogang, Damian, Vincent, Nguyen, Hong T., Matsen, Miles E., Morton, Gregory J., Thaler, Joshua P.

“…Female mice are less susceptible to the negative metabolic consequences of high-fat diet feeding than male mice, for reasons that are incompletely understood…”
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Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents by Scarlett, Jarrad M, Rojas, Jennifer M, Matsen, Miles E, Kaiyala, Karl J, Stefanovski, Darko, Bergman, Richard N, Nguyen, Hong T, Dorfman, Mauricio D, Lantier, Louise, Wasserman, David H, Mirzadeh, Zaman, Unterman, Terry G, Morton, Gregory J, Schwartz, Michael W

“…A single injection of FGF1 into the hypothalamic region of the brain in rodents with diabetes achieves sustained normalization of blood glucose levels in these…”
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Functional identification of a neurocircuit regulating blood glucose by Meek, Thomas H., Nelson, Jarrell T., Matsen, Miles E., Dorfman, Mauricio D., Guyenet, Stephan J., Damian, Vincent, Allison, Margaret B., Scarlett, Jarrad M., Nguyen, Hong T., Thaler, Joshua P., Olson, David P., Myers, Martin G., Schwartz, Michael W., Morton, Gregory J.

“…Previous studies implicate the hypothalamic ventromedial nucleus (VMN) in glycemic control. Here, we report that selective inhibition of the subset of VMN…”
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Kisspeptin Receptor Haplo-insufficiency Causes Premature Ovarian Failure Despite Preserved Gonadotropin Secretion by Gaytan, Francisco, Garcia-Galiano, David, Dorfman, Mauricio D, Manfredi-Lozano, Maria, Castellano, Juan M, Dissen, Gregory A, Ojeda, Sergio R, Tena-Sempere, Manuel

“…Premature ovarian failure (POF) affects 1% of women in reproductive age, but its etiology remains uncertain. Whereas kisspeptins, the products of Kiss1 that…”
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Prostaglandin PGE2 Receptor EP4 Regulates Microglial Phagocytosis and Increases Susceptibility to Diet-Induced Obesity by Niraula, Anzela, Fasnacht, Rachael D, Ness, Kelly M, Frey, Jeremy M, Cuschieri, Sophia A, Dorfman, Mauricio D, Thaler, Joshua P

“…In rodents, susceptibility to diet-induced obesity requires microglial activation, but the molecular components of this pathway remain incompletely defined…”
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1759-P: Prostaglandin PGE2 Receptor EP4 Signaling Deficiency in Microglia Reduces Weight Gain with Transient Glucose Improvements in Diet-Induced Obesity by NIRAULA, ANZELA, FASNACHT, RACHAEL, NESS, KELLY M., FREY, JEREMY, DORFMAN, MAURICIO D., THALER, JOSHUA

“…High fat diet (HFD) triggers a microglial inflammatory response in the mediobasal hypothalamus that is associated with weight gain and glucose dysregulation…”
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CX3CL1 Action on Microglia Protects from Diet-Induced Obesity by Restoring POMC Neuronal Excitability and Melanocortin System Activity Impaired by High-Fat Diet Feeding by Banerjee, Jineta, Dorfman, Mauricio D, Fasnacht, Rachael, Douglass, John D, Wyse-Jackson, Alice C, Barria, Andres, Thaler, Joshua P

“…Both hypothalamic microglial inflammation and melanocortin pathway dysfunction contribute to diet-induced obesity (DIO) pathogenesis. Previous studies…”
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Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance by Douglass, John D, Ness, Kelly M, Valdearcos, Martin, Wyse-Jackson, Alice, Dorfman, Mauricio D, Frey, Jeremy M, Fasnacht, Rachael D, Santiago, Olivia D, Niraula, Anzela, Banerjee, Jineta, Robblee, Megan, Koliwad, Suneil K, Thaler, Joshua P

“…Hypothalamic gliosis associated with high-fat diet (HFD) feeding increases susceptibility to hyperphagia and weight gain. However, the body-weight-independent…”
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Loss of Ntrk2/Kiss1r Signaling in Oocytes Causes Premature Ovarian Failure by Dorfman, Mauricio D, Garcia-Rudaz, Cecilia, Alderman, Zefora, Kerr, Bredford, Lomniczi, Alejandro, Dissen, Gregory A, Castellano, Juan Manuel, Garcia-Galiano, David, Gaytan, Francisco, Xu, Baoji, Tena-Sempere, Manuel, Ojeda, Sergio R

“…Neurotrophins (NTs), once believed to be neural-specific trophic factors, are now known to also provide developmental cues to non-neural cells. In the ovary,…”
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Microglial Inflammatory Signaling Orchestrates the Hypothalamic Immune Response to Dietary Excess and Mediates Obesity Susceptibility by Valdearcos, Martin, Douglass, John D., Robblee, Megan M., Dorfman, Mauricio D., Stifler, Daniel R., Bennett, Mariko L., Gerritse, Irene, Fasnacht, Rachael, Barres, Ben A., Thaler, Joshua P., Koliwad, Suneil K.

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Central androgen action reverses hypothalamic astrogliosis and atherogenic risk factors induced by orchiectomy and high-fat diet feeding in male mice by Dorfman, Mauricio D, Monfeuga, Thomas, Melhorn, Susan J, Kanter, Jenny E, Frey, Jeremy M, Fasnacht, Rachael D, Chandran, Anandhakumar, Lala, Emaad, Velasco, Inmaculada, Rubinow, Katya B, Meek, Thomas H, Schur, Ellen A, Bornfeldt, Karin E, Thaler, Joshua P

“…Hypogonadism in males confers elevated cardiovascular disease (CVD) risk by unknown mechanisms. Recent radiological evidence suggests that low testosterone (T)…”
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152-OR: Evidence Linking Loss of Hypothalamic Perineuronal Nets to Obesity Pathogenesis by ALONGE, KIMBERLY M., DORFMAN, MAURICIO D., SCARLETT, JARRAD M., MELHORN, SUSAN J., YE, YUANCHAO, HU, SHANNON J.W., FRANCIS, KENDRA L., HENDRICKSON, AARUN, CUI, KATHERINE, MORTON, GREGORY J., SCHUR, ELLEN, THALER, JOSHUA, SCHWARTZ, MICHAEL W.

“…Defective neurocircuit activity within the hypothalamic arcuate nucleus (ARC) , a crucial brain area for the regulation of metabolism, is implicated in obesity…”
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1769-P: Microglial Activation and Inactivation via Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) Alters Peripheral Glucose Homeostasis by NESS, KELLY M., DOUGLASS, JOHN, VALDEARCOS-CONTRERAS, MARTIN, DORFMAN, MAURICIO D., NIRAULA, ANZELA, KOLIWAD, SUNEIL K., THALER, JOSHUA

“…Obesity, a condition affecting more than one in three American adults, is associated with hypothalamic neuronal injury, inflammation, and gliosis- a process…”
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212-OR: Testosterone Deficiency Increases Hypothalamic Gliosis and Metabolic Risk by DORFMAN, MAURICIO D., FREY, JEREMY, NESS, KELLY M., NIRAULA, ANZELA, KANTER, JENNY E., BORNFELDT, KARIN, RUBINOW, KATYA, SCHUR, ELLEN, THALER, JOSHUA

“…Obesity is associated with metabolic syndrome and gliosis, the activation of microglia (brain macrophages) and astrocytes, in the mediobasal hypothalamus (MBH)…”
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Deletion of Protein Kinase C λ in POMC Neurons Predisposes to Diet-Induced Obesity by Dorfman, Mauricio D, Krull, Jordan E, Scarlett, Jarrad M, Guyenet, Stephan J, Sajan, Mini P, Damian, Vincent, Nguyen, Hong T, Leitges, Michael, Morton, Gregory J, Farese, Robert V, Schwartz, Michael W, Thaler, Joshua P

“…Effectors of the phosphoinositide 3-kinase (PI3K) signal transduction pathway contribute to the hypothalamic regulation of energy and glucose homeostasis in…”
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Evidence That in Uncontrolled Diabetes, Hyperglucagonemia Is Required for Ketosis but Not for Increased Hepatic Glucose Production or Hyperglycemia by Meek, Thomas H, Dorfman, Mauricio D, Matsen, Miles E, Fischer, Jonathan D, Cubelo, Alexis, Kumar, Monica R, Taborsky, Jr, Gerald J, Morton, Gregory J

“…Several lines of evidence implicate excess glucagon secretion in the elevated rates of hepatic glucose production (HGP), hyperglycemia, and ketosis…”
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