Search Results - "Doremalen, Neeltje"

A Novel Coronavirus Emerging in China — Key Questions for Impact Assessment by Munster, Vincent J, Koopmans, Marion, van Doremalen, Neeltje, van Riel, Debby, de Wit, Emmie

“…A novel coronavirus, designated as 2019-nCoV, emerged in Wuhan, China, at the end of 2019. Although many details of the emergence of this virus remain unknown,…”
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Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1 by van Doremalen, Neeltje, Bushmaker, Trenton, Morris, Dylan H, Holbrook, Myndi G, Gamble, Amandine, Williamson, Brandi N, Tamin, Azaibi, Harcourt, Jennifer L, Thornburg, Natalie J, Gerber, Susan I, Lloyd-Smith, James O, de Wit, Emmie, Munster, Vincent J

“…In this research letter, investigators report on the stability of SARS-CoV-2 and SARS-CoV-1 under experimental conditions. The viability of the two viruses was…”
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Effect of Environmental Conditions on SARS-CoV-2 Stability in Human Nasal Mucus and Sputum by Matson, M Jeremiah, Yinda, Claude Kwe, Seifert, Stephanie N, Bushmaker, Trenton, Fischer, Robert J, van Doremalen, Neeltje, Lloyd-Smith, James O, Munster, Vincent J

“…We found that environmental conditions affect the stability of severe acute respiratory syndrome coronavirus 2 in nasal mucus and sputum. The virus is more…”
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Effectiveness of N95 Respirator Decontamination and Reuse against SARS-CoV-2 Virus by Fischer, Robert J, Morris, Dylan H, van Doremalen, Neeltje, Sarchette, Shanda, Matson, M Jeremiah, Bushmaker, Trenton, Yinda, Claude Kwe, Seifert, Stephanie N, Gamble, Amandine, Williamson, Brandi N, Judson, Seth D, de Wit, Emmie, Lloyd-Smith, James O, Munster, Vincent J

“…The coronavirus pandemic has created worldwide shortages of N95 respirators. We analyzed 4 decontamination methods for effectiveness in deactivating severe…”
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Mechanistic theory predicts the effects of temperature and humidity on inactivation of SARS-CoV-2 and other enveloped viruses by Morris, Dylan H, Yinda, Kwe Claude, Gamble, Amandine, Rossine, Fernando W, Huang, Qishen, Bushmaker, Trenton, Fischer, Robert J, Matson, M Jeremiah, Van Doremalen, Neeltje, Vikesland, Peter J, Marr, Linsey C, Munster, Vincent J, Lloyd-Smith, James O

“…Ambient temperature and humidity strongly affect inactivation rates of enveloped viruses, but a mechanistic, quantitative theory of these effects has been…”
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SARS-CoV-2 disease severity and transmission efficiency is increased for airborne compared to fomite exposure in Syrian hamsters by Port, Julia R., Yinda, Claude Kwe, Owusu, Irene Offei, Holbrook, Myndi, Fischer, Robert, Bushmaker, Trenton, Avanzato, Victoria A., Schulz, Jonathan E., Martens, Craig, van Doremalen, Neeltje, Clancy, Chad S., Munster, Vincent J.

“…Transmission of SARS-CoV-2 is driven by contact, fomite, and airborne transmission. The relative contribution of different transmission routes remains subject…”
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Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4 by van Doremalen, Neeltje, Miazgowicz, Kerri L, Milne-Price, Shauna, Bushmaker, Trenton, Robertson, Shelly, Scott, Dana, Kinne, Joerg, McLellan, Jason S, Zhu, Jiang, Munster, Vincent J

“…Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012. Recently, the MERS-CoV receptor dipeptidyl peptidase 4 (DPP4) was identified and the…”
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SARS-CoV-2 vaccines: anamnestic response in previously infected recipients by Purushotham, Jyothi N., van Doremalen, Neeltje, Munster, Vincent J.

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ChAdOx1 nCoV-19 (AZD1222) protects Syrian hamsters against SARS-CoV-2 B.1.351 and B.1.1.7 by Fischer, Robert J., van Doremalen, Neeltje, Adney, Danielle R., Yinda, Claude Kwe, Port, Julia R., Holbrook, Myndi G., Schulz, Jonathan E., Williamson, Brandi N., Thomas, Tina, Barbian, Kent, Anzick, Sarah L., Ricklefs, Stacy, Smith, Brian J., Long, Dan, Martens, Craig, Saturday, Greg, de Wit, Emmie, Gilbert, Sarah C., Lambe, Teresa, Munster, Vincent J.

“…We investigated ChAdOx1 nCoV-19 (AZD1222) vaccine efficacy against SARS-CoV-2 variants of concern (VOCs) B.1.1.7 and B.1.351 in Syrian hamsters. We previously…”
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Infection with MERS-CoV causes lethal pneumonia in the common marmoset by Falzarano, Darryl, de Wit, Emmie, Feldmann, Friederike, Rasmussen, Angela L, Okumura, Atsushi, Peng, Xinxia, Thomas, Matthew J, van Doremalen, Neeltje, Haddock, Elaine, Nagy, Lee, LaCasse, Rachel, Liu, Tingting, Zhu, Jiang, McLellan, Jason S, Scott, Dana P, Katze, Michael G, Feldmann, Heinz, Munster, Vincent J

“…The availability of a robust disease model is essential for the development of countermeasures for Middle East respiratory syndrome coronavirus (MERS-CoV)…”
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Protective efficacy of a novel simian adenovirus vaccine against lethal MERS-CoV challenge in a transgenic human DPP4 mouse model by Munster, Vincent J., Wells, Daniel, Lambe, Teresa, Wright, Daniel, Fischer, Robert J., Bushmaker, Trenton, Saturday, Greg, van Doremalen, Neeltje, Gilbert, Sarah C., de Wit, Emmie, Warimwe, George M.

“…Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel zoonotic virus that causes severe respiratory disease in humans with a case fatality rate…”
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Immunogenicity of Low-Dose Prime-Boost Vaccination of mRNA Vaccine CV07050101 in Non-Human Primates by van Doremalen, Neeltje, Fischer, Robert J, Schulz, Jonathan E, Holbrook, Myndi G, Smith, Brian J, Lovaglio, Jamie, Petsch, Benjamin, Munster, Vincent J

“…Many different vaccine candidates against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of COVID-19, are currently…”
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Mapping the Specific Amino Acid Residues That Make Hamster DPP4 Functional as a Receptor for Middle East Respiratory Syndrome Coronavirus by van Doremalen, Neeltje, Miazgowicz, Kerri L, Munster, Vincent J

“…The novel emerging coronavirus Middle East respiratory syndrome coronavirus (MERS-CoV) binds to its receptor, dipeptidyl peptidase 4 (DPP4), via 14 interacting…”
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Increased small particle aerosol transmission of B.1.1.7 compared with SARS-CoV-2 lineage A in vivo by Port, Julia R., Yinda, Claude Kwe, Avanzato, Victoria A., Schulz, Jonathan E., Holbrook, Myndi G., van Doremalen, Neeltje, Shaia, Carl, Fischer, Robert J., Munster, Vincent J.

“…The major transmission route for SARS-CoV-2 is airborne. However, previous studies could not elucidate the contribution between large droplets and aerosol…”
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Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models by Cohen, Alexander A, van Doremalen, Neeltje, Greaney, Allison J, Andersen, Hanne, Sharma, Ankur, Starr, Tyler N, Keeffe, Jennifer R, Fan, Chengcheng, Schulz, Jonathan E, Gnanapragasam, Priyanthi N P, Kakutani, Leesa M, West, Jr, Anthony P, Saturday, Greg, Lee, Yu E, Gao, Han, Jette, Claudia A, Lewis, Mark G, Tan, Tiong K, Townsend, Alain R, Bloom, Jesse D, Munster, Vincent J, Bjorkman, Pamela J

“…To combat future severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and spillovers of SARS-like betacoronaviruses (sarbecoviruses)…”
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K18-hACE2 mice develop respiratory disease resembling severe COVID-19 by Yinda, Claude Kwe, Port, Julia R, Bushmaker, Trenton, Offei Owusu, Irene, Purushotham, Jyothi N, Avanzato, Victoria A, Fischer, Robert J, Schulz, Jonathan E, Holbrook, Myndi G, Hebner, Madison J, Rosenke, Rebecca, Thomas, Tina, Marzi, Andrea, Best, Sonja M, de Wit, Emmie, Shaia, Carl, van Doremalen, Neeltje, Munster, Vincent J

“…SARS-CoV-2 emerged in late 2019 and resulted in the ongoing COVID-19 pandemic. Several animal models have been rapidly developed that recapitulate the…”
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Intranasal ChAdOx1 nCoV-19/AZD1222 vaccination reduces viral shedding after SARS-CoV-2 D614G challenge in preclinical models by van Doremalen, Neeltje, Purushotham, Jyothi N, Schulz, Jonathan E, Holbrook, Myndi G, Bushmaker, Trenton, Carmody, Aaron, Port, Julia R, Yinda, Claude K, Okumura, Atsushi, Saturday, Greg, Amanat, Fatima, Krammer, Florian, Hanley, Patrick W, Smith, Brian J, Lovaglio, Jamie, Anzick, Sarah L, Barbian, Kent, Martens, Craig, Gilbert, Sarah C, Lambe, Teresa, Munster, Vincent J

“…ChAdOx1 nCoV-19/AZD1222 is an approved adenovirus-based vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) currently being deployed…”
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Lessons from the pandemic: Responding to emerging zoonotic viral diseases—a Keystone Symposia report by Cable, Jennifer, Fauci, Anthony, Dowling, William E., Günther, Stephan, Bente, Dennis A., Yadav, Pragya Dhruv, Madoff, Lawrence C., Wang, Lin‐Fa, Arora, Rahul K., Van Kerkhove, Maria, Chu, May C., Jaenisch, Thomas, Epstein, Jonathan H., Frost, Simon David William, Bausch, Daniel G., Hensley, Lisa E., Bergeron, Éric, Sitaras, Ioannis, Gunn, Michael D., Geisbert, Thomas W., Muñoz‐Fontela, César, Krammer, Florian, Wit, Emmie, Nordenfelt, Pontus, Saphire, Erica Ollmann, Gilbert, Sarah C., Corbett, Kizzmekia S., Branco, Luis M., Baize, Sylvain, Doremalen, Neeltje, Krieger, Marco A., Clemens, Sue Ann Costa, Hesselink, Renske, Hartman, Dan

“…The COVID‐19 pandemic caught the world largely unprepared, including scientific and policy communities. On April 10–13, 2022, researchers across academia,…”
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Replication and shedding of MERS-CoV in upper respiratory tract of inoculated dromedary camels by Adney, Danielle R, van Doremalen, Neeltje, Brown, Vienna R, Bushmaker, Trenton, Scott, Dana, de Wit, Emmie, Bowen, Richard A, Munster, Vincent J

“…In 2012, a novel coronavirus associated with severe respiratory disease in humans emerged in the Middle East. Epidemiologic investigations identified dromedary…”
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ChAdOx1-vectored Lassa fever vaccine elicits a robust cellular and humoral immune response and protects guinea pigs against lethal Lassa virus challenge by Fischer, Robert J., Purushotham, Jyothi N., van Doremalen, Neeltje, Sebastian, Sarah, Meade-White, Kimberly, Cordova, Kathleen, Letko, Michael, Jeremiah Matson, M., Feldmann, Friederike, Haddock, Elaine, LaCasse, Rachel, Saturday, Greg, Lambe, Teresa, Gilbert, Sarah C., Munster, Vincent J.

“…Lassa virus (LASV) infects hundreds of thousands of individuals each year, highlighting the need for the accelerated development of preventive, diagnostic, and…”
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