Limited recovery from post-acute sequelae of SARS-CoV-2 at 8 months in a prospective cohort
Global attention is gradually turning to focus on the problem of prolonged illness following acute coronavirus disease 2019 (COVID-19), commonly termed “Long COVID” or post-acute sequelae of SARS-CoV-2 infection (PASC). While an increasing number of reports now recognise this condition, accurate cha...
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| Published in: | ERJ open research Vol. 7; no. 4; p. 384 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
European Respiratory Society
01-10-2021
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Global attention is gradually turning to focus on the problem of prolonged illness following acute coronavirus disease 2019 (COVID-19), commonly termed “Long COVID” or post-acute sequelae of SARS-CoV-2 infection (PASC). While an increasing number of reports now recognise this condition, accurate characterisation of its prevalence, clinical features and natural history is complicated by choice of denominator population, lack of case definition and marked self-selection bias. Nevertheless, a picture is emerging of a syndrome characterised predominantly by fatigue, dyspnoea, chest tightness and “brain fog” present in around 10–30% of individuals at 2–3 months post-acute infection and affecting both those with initial severe illness and those in whom acute infection was mild [1–3].
In a longitudinal cohort, a significant proportion of patients had persistent symptoms 8 months after initial #COVID19 infection. There was no significant improvement in symptoms or health-related quality of life between 4- and 8-month assessments.
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 2312-0541 2312-0541 |
| DOI: | 10.1183/23120541.00384-2021 |