Search Results - "Dordal, Alberto"

N-substituted-1,2,3-triazoles: synthesis, characterization and evaluation as cannabinoid ligands by Jagerovic, Nadine, Oliva, Cristina G., Goya, Pilar, Alkorta, Ibon, Elguero, José, Cuberes, Rosa, Dordal, Alberto

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Chronic 5‐HT6 receptor modulation by E‐6837 induces hypophagia and sustained weight loss in diet‐induced obese rats by Fisas, Angels, Codony, Xavier, Romero, Gonzalo, Dordal, Alberto, Giraldo, Jesus, Mercé, Ramon, Holenz, Jörg, Heal, David, Buschmann, Helmut, Pauwels, Petrus Johan

“…1 E‐6837 is a novel, selective and high‐affinity 5‐HT6 receptor ligand (pKi: 9.13) which in vitro demonstrates partial agonism at a presumably silent rat 5‐HT6…”
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Sleep-Stabilizing Effects of E-6199, Compared to Zopiclone, Zolpidem and THIP in Mice by ALEXANDRE, Chloé, DORDAL, Alberto, AIXENDRI, Ramon, GUZMAN, Antonio, HAMON, Michel, ADRIEN, Joëlle

“…Gamma aminobutyric acid (GABA)A receptor modulators constitute the majority of clinically used sedative-hypnotics. These compounds have the capacity to…”
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Medicinal Chemistry Driven Approaches Toward Novel and Selective Serotonin 5-HT6 Receptor Ligands by Holenz, Jörg, Mercè, Ramon, Díaz, José Luis, Guitart, Xavier, Codony, Xavier, Dordal, Alberto, Romero, Gonzalo, Torrens, Antoni, Mas, Josep, Andaluz, Blas, Hernández, Susana, Monroy, Xavier, Sánchez, Elisabeth, Hernández, Enrique, Pérez, Raquel, Cubí, Roger, Sanfeliu, Olga, Buschmann, Helmut

“…Based on a medicinal chemistry guided hypothetical pharmacophore model, novel series of indolyl sulfonamides have been designed and prepared as selective and…”
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Chronic 5‐HT 6 receptor modulation by E‐6837 induces hypophagia and sustained weight loss in diet‐induced obese rats by Fisas, Angels, Codony, Xavier, Romero, Gonzalo, Dordal, Alberto, Giraldo, Jesus, Mercé, Ramon, Holenz, Jörg, Heal, David, Buschmann, Helmut, Pauwels, Petrus Johan

“…E‐6837 is a novel, selective and high‐affinity 5‐HT 6 receptor ligand (p K i : 9.13) which in vitro demonstrates partial agonism at a presumably silent rat…”
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Structural–activity relationship study on C-4 carbon atom of the CB 1 antagonist SR141716: synthesis and pharmacological evaluation of 1,2,4-triazole-3-carboxamides by Jagerovic, Nadine, Hernandez-Folgado, Laura, Alkorta, Ibon, Goya, Pilar, Martín, María Isabel, Dannert, María Teresa, Alsasua, Ángela, Frigola, Jordi, Cuberes, María Rosa, Dordal, Alberto, Holenz, Jörg

“…A series of 1,2,4-triazole-3-carboxamides has been prepared from alkyl-1,2,4-triazole-3-carboxylates under mild conditions. The ability of these triazoles to…”
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Discovery of 5-HT sub(6) receptor ligands based on virtual HTS by Tasler, Stefan, Kraus, Juergen, Wuzik, Andreas, Mueller, Oliver, Aschenbrenner, Andrea, Cubero, Elena, Pascual, Rosalia, Quintana-Ruiz, Jordi-Ramon, Dordal, Alberto, Merce, Ramon, Codony, Xavier

“…Based on a pharmacophore alignment on a 5-HT sub(6) ligand applying 4SCan technology, a new lead series was identified and further structurally investigated. K…”
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Discovery of 5-HT6 receptor ligands based on virtual HTS by TASLER, Stefan, KRAUS, Jurgen, CODONY, Xavier, WUZIK, Andreas, MULLER, Oliver, ASCHENBRENNER, Andrea, CUBERO, Elena, PASCUAL, Rosalia, QUINTANA-RUIZ, Jordi-Ramon, DORDAL, Alberto, MERCE, Ramon

“…Based on a pharmacophore alignment on a 5-HT(6) ligand applying 4SCan technology, a new lead series was identified and further structurally investigated. K(i)s…”
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Structural-activity relationship study on C-4 carbon atom of the CB1 antagonist SR141716 : synthesis and pharmacological evaluation of 1,2,4-triazole-3-carboxamides by JAGEROVIC, Nadine, HERNANDEZ-FOLGADO, Laura, HOLENZ, Jörg, ALKORTA, Ibon, GOYA, Pilar, MARTIN, Maria Isabel, DANNERT, Maria Teresa, ALSASUA, Angela, FRIGOLA, Jordi, CUBERES, Maria Rosa, DORDAL, Alberto

“…A series of 1,2,4-triazole-3-carboxamides has been prepared from alkyl-1,2,4-triazole-3-carboxylates under mild conditions. The ability of these triazoles to…”
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Novel derivatives of 3-alkyl-1,5-diaryl-1H-1,2,4-triazoles and their pharmacological evaluation as CB1 cannabinoid ligands by Hernandez-Folgado, Laura, Goya, Pilar, Frigola, Jordi, Cuberes, María Rosa, Dordal, Alberto, Holenz, Jörg, Jagerovic, Nadine

“…In a previous study, we have identified 3-alkyl-1,5-diaryl-1 H -1,2,4-triazoles to be a novel class of cannabinoid type-1 (CB 1 ) receptor antagonists…”
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Discovery of 5-HT 6 receptor ligands based on virtual HTS by Tasler, Stefan, Kraus, Jürgen, Wuzik, Andreas, Müller, Oliver, Aschenbrenner, Andrea, Cubero, Elena, Pascual, Rosalia, Quintana-Ruiz, Jordi-Ramon, Dordal, Alberto, Mercè, Ramon, Codony, Xavier

“…The discovery and SAR studies of 5-HT 6 ligands are described. Based on a pharmacophore alignment on a 5-HT 6 ligand applying 4SCan ® technology, a new lead…”
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Synthesis of New Benzoxazinone Derivatives as Neuropeptide Y5 Antagonists for the Treatment of Obesity by Torrens, Antoni, Mas, Josep, Port, Adriana, Castrillo, José Aurelio, Sanfeliu, Olga, Guitart, Xavier, Dordal, Alberto, Romero, Gonzalo, Fisas, Ma Angeles, Sánchez, Elisabeth, Hernández, Enrique, Pérez, Pilar, Pérez, Raquel, Buschmann, Helmut

“…Screening of our internal chemical collection against the neuropeptide Y5 (NPY Y5) receptor allowed the identification of a benzoxazine derivative 5f as a hit…”
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A Medicinal-Chemistry-Guided Approach to Selective and Druglike Sigma 1 Ligands by Corbera, Jordi, Vaño, David, Martínez, Daniel, Vela, José M., Zamanillo, Daniel, Dordal, Alberto, Andreu, Francesc, Hernandez, Enric, Perez, Raquel, Escriche, Marisol, Salgado, Leonardo, Yeste, Sandra, Serafini, Maria Teresa, Pascual, Rosalia, Alegre, Júlia, Calvet, Maria Carme, Cano, Núria, Carro, Mónica, Buschmann, Helmut, Holenz, Jörg

“…Based on a medicinal‐chemistry‐guided approach, three novel series of druglike cycloalkyl‐annelated pyrazoles were synthesized and display high affinity (pKi…”
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A preliminary study of the metabolic stability of a series of benzoxazinone derivatives as potent neuropeptide Y5 antagonists: G-protein-coupled receptors in drug discovery by DORDAL, Alberto, LIPKIN, Mike, SPEARING, William, TORRENS, Antoni, YESTE, Sandra, MACRITCHIE, Jackie, MAS, Josep, PORT, Adriana, ROSE, Sally, SALGADO, Leonardo, SAVIC, Vladimir, SCHMIDT, Wolfgang, SERAFINI, Maria Teresa

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Medicinal Chemistry Driven Approaches Toward Novel and Selective Serotonin 5-HT 6 Receptor Ligands by Holenz, Jörg, Mercè, Ramon, Díaz, José Luis, Guitart, Xavier, Codony, Xavier, Dordal, Alberto, Romero, Gonzalo, Torrens, Antoni, Mas, Josep, Andaluz, Blas, Hernández, Susana, Monroy, Xavier, Sánchez, Elisabeth, Hernández, Enrique, Pérez, Raquel, Cubí, Roger, Sanfeliu, Olga, Buschmann, Helmut

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A preliminary study of the metabolic stability of a series of benzoxazinone derivatives as potent neuropeptide Y5 antagonists by Dordal, Alberto, Lipkin, Mike, Macritchie, Jackie, Mas, Josep, Port, Adriana, Rose, Sally, Salgado, Leonardo, Savic, Vladimir, Schmidt, Wolfgang, Serafini, Maria Teresa, Spearing, William, Torrens, Antoni, Yeste, Sandra

“…The metabolic stability of benzoxazinone derivatives, a potent series of NPY5 antagonists, has been investigated. This study identified the moieties prone to…”
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Effects of K+ channel blockers and openers on antinociception induced by agonists of 5-HT1A receptors by ROBLES, L.-I, BARRIOS, M, DEL POZO, E, DORDAL, A, BAEYENS, J. M

“…The modulation by K+ channel-acting drugs of the antinociceptive effect of several 5-HT1A receptor agonists was examined with the hot plate test in mice. All…”
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Effects of K + channel blockers and openers on antinociception induced by agonists of 5-HT 1A receptors by Robles, Luis-Ignacio, Barrios, Manuel, Del Pozo, Esperanza, Dordal, Alberto, Baeyens, JoséM.

“…The modulation by K + channel-acting drugs of the antinociceptive effect of several 5-HT 1A receptor agonists was examined with the hot plate test in mice. All…”
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