Search Results - "Doran, Todd M"

Effect of C-Terminal Modification on the Self-Assembly and Hydrogelation of Fluorinated Fmoc-Phe Derivatives by Ryan, Derek M, Doran, Todd M, Anderson, Samuel B, Nilsson, Bradley L

“…The development of hydrogels resulting from the self-assembly of low molecular weight (LMW) hydrogelators is a rapidly expanding area of study…”
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High-throughput Identification of DNA-Encoded IgG Ligands that Distinguish Active and Latent Mycobacterium tuberculosis Infections by Mendes, Kimberly R, Malone, Marie Lynne, Ndungu, John Maina, Suponitsky-Kroyter, Irena, Cavett, Valerie J, McEnaney, Patrick J, MacConnell, Andrew B, Doran, Todd. M, Ronacher, Katharina, Stanley, Kim, Utset, Ofelia, Walzl, Gerhard, Paegel, Brian M, Kodadek, Thomas

“…The circulating antibody repertoire encodes a patient’s health status and pathogen exposure history, but identifying antibodies with diagnostic potential…”
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Synthesis and screening of bead-displayed combinatorial libraries by Doran, Todd M, Dickson, Paige, Ndungu, John Maina, Ge, Peng, Suponitsky-Kroyter, Irena, An, Hongchan, Kodadek, Thomas

“…The development of faster and less expensive methods to discover bioactive small molecules remains a high priority in chemical biology. This article discusses…”
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Aβ(M1-40) and Wild-Type Aβ40 Self-Assemble into Oligomers with Distinct Quaternary Structures by Bouchard, Jacob L, Davey, Taylor C, Doran, Todd M

“…Amyloid-β oligomers (AβOs) self-assemble into polymorphic species with diverse biological activities that are implicated causally to Alzheimer's disease (AD)…”
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Role of amino acid hydrophobicity, aromaticity, and molecular volume on IAPP(20-29) amyloid self-assembly by Doran, Todd M., Kamens, Alissa J., Byrnes, Nadia K., Nilsson, Bradley L.

“…Aromatic amino acids strongly promote cross‐β amyloid formation; whether the amyloidogenicity of aromatic residues is due to high hydrophobicity and β‐sheet…”
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Utility of Redundant Combinatorial Libraries in Distinguishing High and Low Quality Screening Hits by Doran, Todd M, Gao, Yu, Mendes, Kimberly, Dean, Sonja, Simanski, Scott, Kodadek, Thomas

“…Large one-bead one-compound (OBOC) combinatorial libraries can be constructed relatively easily by solid-phase split and pool synthesis. The use of resins with…”
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Discovery of Phosphorylated Peripherin as a Major Humoral Autoantigen in Type 1 Diabetes Mellitus by Doran, Todd M, Morimoto, Jumpei, Simanski, Scott, Koesema, Eric J, Clark, Lorraine F, Pels, Kevin, Stoops, Sydney L, Pugliese, Alberto, Skyler, Jay S, Kodadek, Thomas

“…A major goal in understanding autoimmune diseases is to define the antigens that elicit a self-destructive immune response, but this is a difficult endeavor…”
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Enhancement of HIV-1 Infectivity by Simple, Self-Assembling Modular Peptides by Easterhoff, David, DiMaio, John T.M., Doran, Todd M., Dewhurst, Stephen, Nilsson, Bradley L.

“…Semen-derived enhancer of viral infection (SEVI), an amyloid fibril formed from a cationic peptide fragment of prostatic acidic phosphatase (PAP), dramatically…”
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High affinity binding of conformationally constrained synthetic oligomers to an antigen-specific antibody: Discovery of a diagnostically useful synthetic ligand for murine Type 1 diabetes autoantibodies by Doran, Todd M., Gao, Yu, Simanski, Scott, McEnaney, Patrick, Kodadek, Thomas

“…[Display omitted] ‘Antigen surrogates’ are synthetic, non-natural molecules that recognize the antigen-binding sites of antibodies. These molecules are of…”
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Discovery of Native Autoantigens via Antigen Surrogate Technology: Application to Type 1 Diabetes by Doran, Todd M, Simanski, Scott, Kodadek, Thomas

“…A fundamental goal in understanding the mechanisms of autoimmune disease is the characterization of autoantigens that are targeted by autoreactive antibodies…”
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Seminal Plasma Accelerates Semen-derived Enhancer of Viral Infection (SEVI) Fibril Formation by the Prostatic Acid Phosphatase (PAP248–286) Peptide by Olsen, Joanna S., DiMaio, John T.M., Doran, Todd M., Brown, Caitlin, Nilsson, Bradley L., Dewhurst, Stephen

“…Amyloid fibrils contained in semen, known as SEVI, or semen-derived enhancer of viral infection, have been shown to increase the infectivity of HIV…”
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Amyloid-binding Small Molecules Efficiently Block SEVI (Semen-derived Enhancer of Virus Infection)- and Semen-mediated Enhancement of HIV-1 Infection by Olsen, Joanna S., Brown, Caitlin, Capule, Christina C., Rubinshtein, Mark, Doran, Todd M., Srivastava, Rajesh K., Feng, Changyong, Nilsson, Bradley L., Yang, Jerry, Dewhurst, Stephen

“…Semen was recently shown to contain amyloid fibrils formed from a self-assembling peptide fragment of the protein prostatic acid phosphatase. These amyloid…”
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Reliable diagnosis of murine type 1 diabetes using a panel of autoantigens and "antigen surrogates" mounted onto a liquid array by Doran, Todd M, Morimoto, Jumpei, Simanski, Scott, McEnaney, Patrick J, Kodadek, Thomas

“…Autoantibodies raised against β cell antigens are the most reliable preclinical biomarkers for predicting the imminent onset of type 1 diabetes mellitus…”
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Chemical Tools To Monitor and Manipulate Adaptive Immune Responses by Doran, Todd M, Sarkar, Mohosin, Kodadek, Thomas

“…Methods to monitor and manipulate the immune system are of enormous clinical interest. For example, the development of vaccines represents one of the earliest…”
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Photocaged dicarbonyl probe provides spatiotemporal control over protein glycation by Hurben, Alexander K, Ge, Peng, Bouchard, Jacob L, Doran, Todd M, Tretyakova, Natalia Y

“…Protein glycation is a disease associated, non-enzymatic, posttranslational modification generated by endogenous dicarbonyl metabolites. Currently, there is a…”
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Proteome-Wide Profiling of Cellular Targets Modified by Dopamine Metabolites Using a Bio-Orthogonally Functionalized Catecholamine by Hurben, Alexander K, Erber, Luke N, Tretyakova, Natalia Y, Doran, Todd M

“…Selective death of midbrain dopaminergic neurons is a hallmark pathology of Parkinson’s disease (PD), but the molecular mechanisms that initiate the cascade of…”
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Complementary π–π Interactions Induce Multicomponent Coassembly into Functional Fibrils by Ryan, Derek M, Doran, Todd M, Nilsson, Bradley L

“…Noncovalent self-assembled materials inspired by amyloid architectures are useful for biomedical applications ranging from regenerative medicine to drug…”
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Modulating Supramolecular Peptide Hydrogel Viscoelasticity Using Biomolecular Recognition by DiMaio, John T. M, Doran, Todd M, Ryan, Derek M, Raymond, Danielle M, Nilsson, Bradley L

“…Self-assembled peptide-based hydrogels are emerging materials that have been exploited for wound healing, drug delivery, tissue engineering, and other…”
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Stabilizing self-assembled Fmoc-F5-Phe hydrogels by co-assembly with PEG-functionalized monomers by Ryan, Derek M, Doran, Todd M, Nilsson, Bradley L

“…Hydrogels derived from self-assembled Fmoc-F(5)-Phe fibrils are stabilized with respect to shear-response by co-assembly with C-terminal PEG-functionalized…”
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A Liquid Array Platform for the Multiplexed Analysis of Synthetic Molecule–Protein Interactions by Doran, Todd M, Kodadek, Thomas

“…Synthetic molecule microarrays, consisting of many different compounds spotted onto a planar surface such as modified glass or cellulose, have proven to be…”
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