Search Results - "Doran, S D"

Precision Control of the Electron Longitudinal Bunch Shape Using an Emittance-Exchange Beam Line by Ha, G, Cho, M H, Namkung, W, Power, J G, Doran, D S, Wisniewski, E E, Conde, M, Gai, W, Liu, W, Whiteford, C, Gao, Q, Kim, K-J, Zholents, A, Sun, Y-E, Jing, C, Piot, P

“…We report on the experimental generation of relativistic electron bunches with a tunable longitudinal bunch shape. A longitudinal bunch-shaping (LBS) beam…”
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Observation of High Transformer Ratio of Shaped Bunch Generated by an Emittance-Exchange Beam Line by Gao, Q, Ha, G, Jing, C, Antipov, S P, Power, J G, Conde, M, Gai, W, Chen, H, Shi, J, Wisniewski, E E, Doran, D S, Liu, W, Whiteford, C E, Zholents, A, Piot, P, Baturin, S S

“…Collinear wakefield acceleration has been long established as a method capable of generating ultrahigh acceleration gradients. Because of the success on this…”
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Author Correction: Fabrication of THz corrugated wakefield structure and its high power test by Kong, H., Chung, M., Doran, D. S., Ha, G., Kim, S.-H., Kim, J.-H., Liu, W., Lu, X., Power, J., Seok, J.-M., Shin, S., Shao, J., Whiteford, C., Wisniewski, E.

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Fabrication of THz corrugated wakefield structure and its high power test by Kong, H., Chung, M., Doran, D. S., Ha, G., Kim, S.-H., Kim, J.-H., Liu, W., Lu, X., Power, J., Seok, J.-M., Shin, S., Shao, J., Whiteford, C., Wisniewski, E.

“…We present overall process for developing terahertz (THz) corrugated structure and its beam-based measurement results. 0.2-THz corrugated structures were…”
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Single Shot Characterization of High Transformer Ratio Wakefields in Nonlinear Plasma Acceleration by Roussel, R, Andonian, G, Lynn, W, Sanwalka, K, Robles, R, Hansel, C, Deng, A, Lawler, G, Rosenzweig, J B, Ha, G, Seok, J, Power, J G, Conde, M, Wisniewski, E, Doran, D S, Whiteford, C E

“…Plasma wakefields can enable very high accelerating gradients for frontier high energy particle accelerators, in excess of 10  GeV/m. To overcome limits on…”
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Demonstration of eigen-to-projected emittance mapping for an ellipsoidal electron bunch by Xu, T., Doran, D. S., Liu, W., Piot, P., Power, J. G., Whiteford, C., Wisniewski, E.

“…Phase-space partitioning offers an attractive path for the precise tailoring of complex dynamical systems. In beam physics, the proposed approach involves (i)…”
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Demonstration of sub- GV / m accelerating field in a photoemission electron gun powered by nanosecond X -band radio-frequency pulses by Tan, W. H., Antipov, S., Doran, D. S., Ha, G., Jing, C., Knight, E., Kuzikov, S., Liu, W., Lu, X., Piot, P., Power, J. G., Shao, J., Whiteford, C., Wisniewski, E. E.

“…Radio-frequency (rf) photoemission electron guns operating at higher accelerating gradients offer a pathway to produce brighter electron bunches. Brighter…”
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Observation of Skewed Electromagnetic Wakefields in an Asymmetric Structure Driven by Flat Electron Bunches by Lynn, W, Xu, T, Andonian, G, Doran, D S, Ha, G, Majernik, N, Piot, P, Power, J, Rosenzweig, J B, Whiteford, C, Wisniewski, E

“…Relativistic charged-particle beams that generate intense longitudinal fields in accelerating structures also inherently couple to transverse modes. The…”
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Design and synthesis of potent amido- and benzyl-substituted cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl DPP-IV inhibitors by Corbett, J.W., Dirico, K., Song, W., Boscoe, B.P., Doran, S.D., Boyer, D., Qiu, X., Ammirati, M., VanVolkenburg, M.A., McPherson, R.K., Parker, J.C., Cox, E.D.

“…The cis-3-amino-4-(2-cyanopyrrolidide)-pyrrolidine template has been shown to afford low nanomolar inhibitors of human DPP-IV that exhibit a robust PK/PD…”
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Demonstration of transport of a patterned electron beam produced by diamond pyramid cathode in an rf gun by Nichols, K. E., Andrews, H. L., Kim, D., Simakov, E. I., Conde, M., Doran, D. S., Ha, G., Liu, W., Power, J. F., Shao, J., Whiteford, C., Wisniewski, E. E., Antipov, S. P., Chen, G.

“…We have demonstrated generation and transport of a patterned electron beam from a Diamond Field-Emitter Array (DFEA) cathode in a radio frequency (rf) gun…”
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New state record for Culiseta impatiens in Maryland by Pagac, Jr, B B, Harlan, H J, Doran, S D, Brosnihan, M A

“…Culiseta impatiens is reported for the first time from Maryland. Collections from the southwestern border of Fort George G. Meade extend the range of this…”
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Observation of High Transformer Ratio of Shaped Bunch Generated by an Emittance-Exchange Beam Line by Gao, Q., Ha, G., Jing, C., Antipov, S. P., Power, J. G., Conde, M., Gai, W., Chen, H., Shi, J., Wisniewski, E. E., Doran, D. S., Liu, W., Whiteford, C. E., Zholents, A., Piot, P., Baturin, S. S.

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Precision Control of the Electron Longitudinal Bunch Shape Using an Emittance-Exchange Beam Line by Ha, G., Cho, M. H., Namkung, W., Power, J. G., Doran, D. S., Wisniewski, E. E., Conde, M., Gai, W., Liu, W., Whiteford, C., Gao, Q., Kim, K. -J., Zholents, A., Sun, Y. -E, Jing, C., Piot, P

“…We report on the experimental generation of relativistic electron bunches with a tunable longitudinal bunch shape. A longitudinal bunch-shaping (LBS) beam…”
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First-in-Human Evaluation of 18F-PF-06445974, a PET Radioligand That Preferentially Labels Phosphodiesterase-4B by Wakabayashi, Yuichi, Stenkrona, Per, Arakawa, Ryosuke, Yan, Xuefeng, Van Buskirk, Maia G, Jenkins, Madeline D, Santamaria, Jose A Montero, Maresca, Kevin P, Takano, Akihiro, Liow, Jeih-San, Chappie, Thomas A, Varrone, Andrea, Nag, Sangram, Zhang, Lei, Hughes, Zoë A, Schmidt, Christopher J, Doran, Shawn D, Mannes, Andrew, Zanotti-Fregonara, Paolo, Ooms, Maarten, Morse, Cheryl L, Zoghbi, Sami S, Halldin, Christer, Pike, Victor W, Innis, Robert B

“…Phosphodiesterase-4 (PDE4), which metabolizes the second messenger cyclic adenosine monophosphate (cAMP), has 4 isozymes: PDE4A, PDE4B, PDE4C, and PDE4D. PDE4B…”
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Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation by O’Neill, Brian T, Beck, Elizabeth M, Butler, Christopher R, Nolan, Charles E, Gonzales, Cathleen, Zhang, Lei, Doran, Shawn D, Lapham, Kimberly, Buzon, Leanne M, Dutra, Jason K, Barreiro, Gabriela, Hou, Xinjun, Martinez-Alsina, Luis A, Rogers, Bruce N, Villalobos, Anabella, Murray, John C, Ogilvie, Kevin, LaChapelle, Erik A, Chang, Cheng, Lanyon, Lorraine F, Steppan, Claire M, Robshaw, Ashley, Hales, Katherine, Boucher, Germaine G, Pandher, Karamjeet, Houle, Christopher, Ambroise, Claude W, Karanian, David, Riddell, David, Bales, Kelly R, Brodney, Michael A

“…A major challenge in the development of β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors for the treatment of Alzheimer’s disease is the…”
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Identification of a Novel Positron Emission Tomography (PET) Ligand for Imaging β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE-1) in Brain by Zhang, Lei, Chen, Laigao, Dutra, Jason K, Beck, Elizabeth M, Nag, Sangram, Takano, Akihiro, Amini, Nahid, Arakawa, Ryosuke, Brodney, Michael A, Buzon, Leanne M, Doran, Shawn D, Lanyon, Lorraine F, McCarthy, Timothy J, Bales, Kelly R, Nolan, Charles E, O’Neill, Brian T, Schildknegt, Klaas, Halldin, Christer, Villalobos, Anabella

“…Alzheimer’s disease (AD) is characterized by accumulation of β-amyloid (Aβ) plaques and neurofibrillary tau tangles in the brain. β-Site amyloid precursor…”
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Quantitative Analysis of 18 F-PF-06684511, a Novel PET Radioligand for Selective β-Secretase 1 Imaging, in Nonhuman Primate Brain by Takano, Akihiro, Chen, Laigao, Nag, Sangram, Brodney, Michael A, Arakawa, Ryosuke, Chang, Cheng, Amini, Nahid, Doran, Shawn D, Dutra, Jason K, McCarthy, Timothy J, Nolan, Charles E, O'Neill, Brian T, Villalobos, Anabella, Zhang, Lei, Halldin, Christer

“…β-secretase 1 (BACE1) is a key enzyme in the generation of β-amyloid, which is accumulated in the brain of Alzheimer disease patients. PF-06684511 was…”
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Quantitative Analysis of 18F-PF-06684511, a Novel PET Radioligand for Selective β-Secretase 1 Imaging, in Nonhuman Primate Brain by Takano, Akihiro, Chen, Laigao, Nag, Sangram, Brodney, Michael A, Arakawa, Ryosuke, Chang, Cheng, Amini, Nahid, Doran, Shawn D, Dutra, Jason K, McCarthy, Timothy J, Nolan, Charles E, O'Neill, Brian T, Villalobos, Anabella, Zhang, Lei, Halldin, Christer

“…β-secretase 1 (BACE1) is a key enzyme in the generation of β-amyloid, which is accumulated in the brain of Alzheimer disease patients. PF-06684511 was…”
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Use of a physiologically based pharmacokinetic model to study the time to reach brain equilibrium: an experimental analysis of the role of blood-brain barrier permeability, plasma protein binding, and brain tissue binding by Liu, Xingrong, Smith, Bill J, Chen, Cuiping, Callegari, Ernesto, Becker, Stacey L, Chen, Xi, Cianfrogna, Julie, Doran, Angela C, Doran, Shawn D, Gibbs, John P, Hosea, Natilie, Liu, Jianhua, Nelson, Frederick R, Szewc, Mark A, Van Deusen, Jeffery

“…This study was designed 1) to examine the effects of blood-brain barrier (BBB) permeability [quantified as permeability-surface area product (PS)], unbound…”
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Corrigendum to “Design and synthesis of potent amido- and benzyl-substituted cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl DPP-IV inhibitors” [Bioorg. Med. Chem. Lett. 17 (2007) 6707–6713] by Corbett, J.W., Dirico, K., Song, W., Boscoe, B.P., Doran, S.D., Boyer, D., Qiu, X., Ammirati, M., VanVolkenburg, M.A., McPherson, R.K., Parker, J.C., Cox, E.D.

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