Search Results - "Dora, K A"

EDH: endothelium‐dependent hyperpolarization and microvascular signalling by Garland, C. J., Dora, K. A.

“…Endothelium‐dependent hyperpolarizing factor (EDHF) is a powerful vasodilator influence in small resistance arteries and thus an important modulator of blood…”
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TRPM4 inhibitor 9‐phenanthrol activates endothelial cell intermediate conductance calcium‐activated potassium channels in rat isolated mesenteric artery by Garland, C J, Smirnov, S V, Bagher, P, Lim, C S, Huang, C Y, Mitchell, R, Stanley, C, Pinkney, A, Dora, K A

“…Background and Purpose Smooth muscle transient receptor potential melastatin 4 (TRPM4) channels play a fundamental role in the development of the myogenic…”
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Small- and intermediate-conductance calcium-activated K+ channels provide different facets of endothelium-dependent hyperpolarization in rat mesenteric artery by Crane, G. J., Gallagher, N., Dora, K. A., Garland, C. J.

“…Activation of both small-conductance (SK Ca ) and intermediate-conductance (IK Ca ) Ca 2+ -activated K + channels in endothelial cells leads to vascular smooth…”
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K + is an endothelium-derived hyperpolarizing factor in rat arteries by Weston, A. H, Edwards, G, Dora, K. A, Gardener, M. J, Garland, C. J

“…In arteries, muscarinic agonists such as acetylcholine release an unidentified, endothelium-derived hyperpolarizing factor (EDHF) which is neither prostacyclin…”
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Desensitization of endothelial P2Y1 receptors by PKC‐dependent mechanisms in pressurized rat small mesenteric arteries by Rodríguez‐Rodríguez, R, Yarova, P, Winter, P, Dora, KA

“…Background and purpose:  Extracellular nucleotides play a crucial role in the regulation of vascular tone and blood flow. Stimulation of endothelial cell P2Y1…”
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Conducted dilatation to ATP and K+ in rat skeletal muscle arterioles by Dora, K. A.

“…Aim During exercise in humans, circulating levels of ATP and K+ increase at a time when blood flow increases to satisfy metabolic demand. Both molecules can…”
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Elevation of Intracellular Calcium in Smooth Muscle Causes Endothelial Cell Generation of NO in Arterioles by Dora, K. A., Doyle, M. P., Duling, B. R.

“…It is well known that vascular smooth muscle tone can be modulated by signals arising in the endothelium (e.g., endothelium-derived relaxing factor,…”
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An indirect influence of phenylephrine on the release of endothelium‐derived vasodilators in rat small mesenteric artery by Dora, K A, Hinton, J M, Walker, S D, Garland, C J

“…The possibility that stimulation of smooth muscle α1‐adrenoceptors modulates contraction via the endothelium was examined in rat small mesenteric arteries…”
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Vascular hyperpolarization to β‐adrenoceptor agonists evokes spreading dilatation in rat isolated mesenteric arteries by Garland, CJ, Yarova, PL, Jiménez‐Altayó, F, Dora, KA

“…BACKGROUND AND PURPOSE β‐Adrenoceptor stimulation causes pronounced vasodilatation associated with smooth muscle hyperpolarization. Although the…”
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Activation of endothelial cell IKCa with 1‐ethyl‐2‐benzimidazolinone evokes smooth muscle hyperpolarization in rat isolated mesenteric artery by Walker, S D, Dora, K A, Ings, N T, Crane, G J, Garland, C J

“…In rat small mesenteric arteries contracted with phenylephrine, 1‐ethyl‐2‐benzimidazolinone (1‐EBIO; 3 – 300 μM) evoked concentration‐dependent relaxation…”
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Vascular and endocrine control of muscle metabolism by Clark, M G, Colquhoun, E Q, Rattigan, S, Dora, K A, Eldershaw, T P, Hall, J L, Ye, J

“…Important differences exist between perfused and incubated (or perifused) skeletal muscle preparations with regard to their metabolism and control. A growing…”
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Properties of smooth muscle hyperpolarization and relaxation to K+ in the rat isolated mesenteric artery by Dora, K A, Garland, C J

“…Smooth muscle membrane potential and tension in rat isolated small mesenteric arteries (inner diameter 100-200 microm) were measured simultaneously to…”
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Evidence for a differential cellular distribution of inward rectifier K channels in the rat isolated mesenteric artery by Crane, G J, Walker, S D, Dora, K A, Garland, C J

“…The distribution of functionally active, inwardly rectifying K (K(IR)) channels was investigated in the rat small mesenteric artery using both freshly isolated…”
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Endothelial cell protein kinase G inhibits release of EDHF through a PKG-sensitive cation channel by Dora, K A, Garland, C J, Kwan, H Y, Yao, X

“…The release of dilator agents from vascular endothelial cells is modulated by changes in cytosolic Ca(2+) concentration ([Ca(2+)](i)). In this study, we…”
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Perfused skeletal muscle contraction and metabolism improved by angiotensin II-mediated vasoconstriction by Rattigan, S, Dora, K A, Tong, A C, Clark, M G

“…In the present study, the effects of angiotensin II (ANG II) on tension development and associated metabolism during twitch and tetanic stimulation via the…”
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[beta]1-Adrenoceptor stimulation suppresses endothelial IKCa-channel hyperpolarization and associated dilatation in resistance arteries by Yarova, PL, Smirnov, SV, Dora, KA, Garland, CJ

“…Background and Purpose In small arteries, small conductance Ca2+-activated K+ channels (SKCa) and intermediate conductance Ca2+-activated K+ channels (IKCa)…”
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Evidence against C‐type natriuretic peptide as an arterial ‘EDHF’ by Garland, C J, Dora, K A

“…C‐type natriuretic peptide (CNP) is found in and released from vascular endothelial cells. Recently, a novel role has been suggested for this peptide, that of…”
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Norepinephrine and serotonin vasoconstriction in rat hindlimb control different vascular flow routes by Newman, J M, Dora, K A, Rattigan, S, Edwards, S J, Colquhoun, E Q, Clark, M G

“…The vasoconstrictors, norepinephrine at low dose ( < or = 0.1 microM; LDNE) and serotonin (5-HT), produce opposing metabolic effects in the constant-flow…”
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The involvement of intracellular Ca2+ in 5‐HT1B/1D receptor‐mediated contraction of the rabbit isolated renal artery by Hill, P B, Dora, K A, Hughes, A D, Garland, C J

“…5‐Hydroxytryptamine1B/1D (5‐HT1B/1D) receptor coupling to contraction was investigated in endothelium‐denuded rabbit isolated renal arteries, by simultaneously…”
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A test of the role of flow-dependent dilation in arteriolar responses to occlusion by McGahren, E D, Dora, K A, Damon, D N, Duling, B R

“…At an arteriolar bifurcation, occlusion of one of the branch arterioles has been reported to result in an increase in flow, shear stress, and vasodilation in…”
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