Search Results - "Doppler, Wolfgang"

Lapatinib and doxorubicin enhance the Stat1‐dependent antitumor immune response by Hannesdóttir, Lára, Tymoszuk, Piotr, Parajuli, Nirmala, Wasmer, Marie‐Helene, Philipp, Sonja, Daschil, Nina, Datta, Sebak, Koller, Johann‐Benedikt, Tripp, Christoph H., Stoitzner, Patrizia, Müller‐Holzner, Elisabeth, Wiegers, Gerrit Jan, Sexl, Veronika, Villunger, Andreas, Doppler, Wolfgang

“…The dual erbB1/2 tyrosine kinase inhibitor lapatinib as well as the anthracycline doxorubicin are both used in the therapy of HER2‐positive breast cancer…”
Get full text

Diverse Functions of IGF/Insulin Signaling in Malignant and Noncancerous Prostate Cells: Proliferation in Cancer Cells and Differentiation in Noncancerous Cells by Heidegger, Isabel, Ofer, Philipp, Doppler, Wolfgang, Rotter, Varda, Klocker, Helmut, Massoner, Petra

“…The insulin-like growth factor (IGF) pathway represents one of the most studied molecular regulatory networks in oncology. Clinical trials investigating the…”
Get full text

Toll‐like receptor 9 expression in breast and ovarian cancer is associated with poorly differentiated tumors by Berger, Regina, Fiegl, Heidi, Goebel, Georg, Obexer, Petra, Ausserlechner, Michael, Doppler, Wolfgang, Hauser‐Kronberger, Cornelia, Reitsamer, Roland, Egle, Daniel, Reimer, Daniel, Müller‐Holzner, Elisabeth, Jones, Allison, Widschwendter, Martin

“…Toll‐like receptor 9 (TLR9) activates the innate immune response when exposed to non‐methylated CpG‐DNA. TLR9 was recently shown to be expressed by cancer…”
Get full text

Complement-Opsonized HIV-1 Overcomes Restriction in Dendritic Cells by Posch, Wilfried, Steger, Marion, Knackmuss, Ulla, Blatzer, Michael, Baldauf, Hanna-Mari, Doppler, Wolfgang, White, Tommy E, Hörtnagl, Paul, Diaz-Griffero, Felipe, Lass-Flörl, Cornelia, Hackl, Hubert, Moris, Arnaud, Keppler, Oliver T, Wilflingseder, Doris

“…DCs express intrinsic cellular defense mechanisms to specifically inhibit HIV-1 replication. Thus, DCs are productively infected only at very low levels with…”
Get full text

Langerhans cells and NK cells cooperate in the inhibition of chemical skin carcinogenesis by Ortner, Daniela, Tripp, Christoph H., Komenda, Kerstin, Dubrac, Sandrine, Zelger, Bernhard, Hermann, Martin, Doppler, Wolfgang, Tymoszuk, Piotr Z., Boon, Louis, Clausen, Björn E., Stoitzner, Patrizia

“…Tissue immunosurveillance is an important mechanism to prevent cancer. Skin treatment with the carcinogen 7,12-dimethylbenz(a)anthracene (DMBA), followed by…”
Get full text

Favorable prognostic value of SOCS2 and IGF-I in breast cancer by Haffner, Michael C, Petridou, Barbara, Peyrat, Jean Phillipe, Révillion, Françoise, Müller-Holzner, Elisabeth, Daxenbichler, Günter, Marth, Christian, Doppler, Wolfgang

“…Suppressor of cytokine signaling (SOCS) proteins comprise a protein family, which has initially been described as STAT induced inhibitors of the Jak/Stat…”
Get full text

Suppressor of Cytokine Signaling (SOCS)-1 Is Expressed in Human Prostate Cancer and Exerts Growth-Inhibitory Function through Down-Regulation of Cyclins and Cyclin-Dependent Kinases by Neuwirt, Hannes, Puhr, Martin, Santer, Frédéric R, Susani, Martin, Doppler, Wolfgang, Marcias, Gemma, Rauch, Veronika, Brugger, Maria, Hobisch, Alfred, Kenner, Lukas, Culig, Zoran

“…Suppressor of cytokine signaling (SOCS) proteins play a pivotal role in the development and progression of various cancers. We have previously shown that…”
Get full text

Prognostic Significance of Signal Transducer and Activator of Transcription 1 Activation in Breast Cancer by WIDSCHWENDTER, Andreas, TONKO-GEYMAYER, Sibylle, WELTE, Thomas, DAXENBICHLER, Günter, MARTH, Christian, DOPPLER, Wolfgang

“…Purpose: Signal transducers and activators of transcription (STATs)were shown to be activated in mammary carcinoma. Because different STAT factors are likely…”
Get full text

Interaction and Functional Interference of Glucocorticoid Receptor and SOCS1 by Haffner, Michael C., Jurgeit, Andreas, Berlato, Chiara, Geley, Stephan, Parajuli, Nirmala, Yoshimura, Akihiko, Doppler, Wolfgang

“…Cytokine and glucocorticoid (GC) hormone signaling act in an integrated fashion to control inflammation and immune response. Here we establish a new mode of…”
Get full text

Regulation and Function of the Cytokine-Inducible SH-2 Domain Proteins, CIS and SOCS3, in Mammary Epithelial Cells by Tonko-Geymayer, Sibylle, Goupille, Olivier, Tonko, Martin, Soratroi, Claudia, Yoshimura, Akihiko, Streuli, Charles, Ziemiecki, Andrew, Kofler, Reinhard, Doppler, Wolfgang

“…The cytokine-inducible src homology 2 (SH-2) proteins, CIS (cytokine inducible SH-2 domain protein) and SOCS3 (suppressor of cytokine signaling 3), are…”
Get full text

Selective Response to Insulin Versus Insulin-Like Growth Factor-I and -II and Up-Regulation of Insulin Receptor Splice Variant B in the Differentiated Mouse Mammary Epithelium by Berlato, Chiara, Doppler, Wolfgang

“…The terminal differentiation of the mouse mammary gland epithelium during lactation has been shown to require IGFs and/or superphysiological levels of insulin…”
Get full text

Expression Level-Dependent Contribution of Glucocorticoid Receptor Domains for Functional Interaction with STAT5 by Doppler, Wolfgang, Windegger, Michaela, Soratroi, Claudia, Tomasi, Jürgen, Lechner, Judith, Rusconi, Sandro, Cato, Andrew C. B., Almlöf, Tova, Liden, Johan, Okret, Sam, Gustafsson, Jan-Åke, Richard-Foy, Hélène, Starr, D. Barry, Klocker, Helmut, Edwards, Dean, Geymayer, Sibylle

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Regulation of mitochondrial ROS production by HIC‐5: a common feature of oncogene‐induced senescence and tumor invasiveness? by Doppler, Wolfgang, Jansen‐Dürr, Pidder

“…Transformation by the ras oncogene can result in promotion of metastasis as well as induction of senescence via increased tissue remodeling, for example, by…”
Get full text

Impact of STAT1 and CD8+ T cells on the antineoplastic activity of lapatinib and doxorubicin against spontaneous mammary tumors by Tymoszuk, Piotr, Doppler, Wolfgang

“…We have recently demonstrated that CD8 + T cells provide a critical contribution to the antineoplastic activity of 2 chemotherapeutic agents, i.e., doxorubicin…”
Get full text

Precision-cut slice cultures of tumors from MMTV-neu mice for the study of the ex vivo response to cytokines and cytotoxic drugs by Parajuli, Nirmala, Doppler, Wolfgang

“…Ex vivo analysis of signaling pathways operating in tumor tissue is complicated by the three-dimensional structure, in particular by stroma-epithelial…”
Get full text

In situ proliferation contributes to accumulation of tumor‐associated macrophages in spontaneous mammary tumors by Tymoszuk, Piotr, Evens, Hanneke, Marzola, Vanessa, Wachowicz, Katarzyna, Wasmer, Marie‐Helene, Datta, Sebak, Müller‐Holzner, Elisabeth, Fiegl, Heidi, Böck, Günther, Rooijen, Nico, Theurl, Igor, Doppler, Wolfgang

“…Infiltration of a neoplasm with tumor‐associated macrophages (TAMs) is considered an important negative prognostic factor and is functionally associated with…”
Get full text

Comparative study on the phosphotyrosine motifs of different cytokine receptors involved in STAT5 activation by May, Petra, Gerhartz, Claudia, Heesel, Birgit, Welte, Thomas, Doppler, Wolfgang, Graeve, Lutz, Horn, Friedemann, Heinrich, Peter C.

“…Several cytokines and growth factors activate transcription of their target genes via the JAK/STAT signalling pathway. It has been shown that the interaction…”
Get full text

High STAT1 mRNA levels but not its tyrosine phosphorylation are associated with macrophage infiltration and bad prognosis in breast cancer by Tymoszuk, Piotr, Charoentong, Pornpimol, Hackl, Hubert, Spilka, Rita, Müller-Holzner, Elisabeth, Trajanoski, Zlatko, Obrist, Peter, Revillion, Françoise, Peyrat, Jean-Philippe, Fiegl, Heidi, Doppler, Wolfgang

“…STAT1 has been attributed a function as tumor suppressor. However, in breast cancer data from microarray analysis indicated a predictive value of high mRNA…”
Get full text

Replenishment of the B cell compartment after doxorubicin‐induced hematopoietic toxicity is facilitated by STAT1 by Datta, Sebak, Parajuli, Nirmala, Tymoszuk, Piotr, Ottina, Eleonora, Parson, Walther, Sgonc, Roswitha, Villunger, Andreas, Doppler, Wolfgang

“…Lymphoid development before differentiation to pre‐B cells is impaired in STAT1‐deficient mice, and apparent in the recovery phase of doxorubicin‐induced…”
Get full text

High expression of prostate-specific membrane antigen in the tumor-associated neo-vasculature is associated with worse prognosis in squamous cell carcinoma of the oral cavity by Haffner, Michael C, Laimer, Johannes, Chaux, Alcides, Schäfer, Georg, Obrist, Peter, Brunner, Andrea, Kronberger, Irmgard E, Laimer, Klaus, Gurel, Bora, Koller, Johann-Benedikt, Seifarth, Christof, Zelger, Bettina, Klocker, Helmut, Rasse, Michael, Doppler, Wolfgang, Bander, Neil H

“…Prostate-specific membrane antigen (PSMA) is a transmembrane protein expressed in prostate cancer as well as in the neo-vasculature of nonprostatic solid…”
Get full text