Search Results - "Dopkins, Nicholas"

The role of gut microbiome and associated metabolome in the regulation of neuroinflammation in multiple sclerosis and its implications in attenuating chronic inflammation in other inflammatory and autoimmune disorders by Dopkins, Nicholas, Nagarkatti, Prakash S., Nagarkatti, Mitzi

“…Summary The importance of the gut microbiome in the regulation of non‐infectious diseases has earned unprecedented interest from biomedical researchers…”
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Tryptamine Attenuates Experimental Multiple Sclerosis Through Activation of Aryl Hydrocarbon Receptor by Dopkins, Nicholas, Becker, William, Miranda, Kathryn, Walla, Mike, Nagarkatti, Prakash, Nagarkatti, Mitzi

“…Tryptamine is a naturally occurring monoamine alkaloid which has been shown to act as an aryl hydrocarbon receptor (AHR) agonist. It is produced in large…”
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Ribosomal profiling of human endogenous retroviruses in healthy tissues by Dopkins, Nicholas, Singh, Bhavya, Michael, Stephanie, Zhang, Panpan, Marston, Jez L, Fei, Tongyi, Singh, Manvendra, Feschotte, Cedric, Collins, Nicholas, Bendall, Matthew L, Nixon, Douglas F

“…Human endogenous retroviruses (HERVs) are the germline embedded proviral fragments of ancient retroviral infections that make up roughly 8% of the human…”
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AhR Activation Leads to Attenuation of Murine Autoimmune Hepatitis: Single-Cell RNA-Seq Analysis Reveals Unique Immune Cell Phenotypes and Gene Expression Changes in the Liver by Cannon, Alkeiver S, Holloman, Bryan Latrell, Wilson, Kiesha, Miranda, Kathryn, Dopkins, Nicholas, Nagarkatti, Prakash, Nagarkatti, Mitzi

“…The aryl hydrocarbon receptor (AhR) is a ubiquitously expressed ligand-activated transcription factor. While initially identified as an environmental sensor,…”
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Regulation of Bacteroides acidifaciens by the aryl hydrocarbon receptor in IL-22-producing immune cells has sex-dependent consequential impact on colitis by Mitchell, Chandani, Staley, Shanieka, Williams, Michal Claire, Saxena, Archana, Bogdon, Raymond, Roark, Kasie, Hailey, Michele, Miranda, Kathryn, Becker, William, Dopkins, Nicholas, Pena, Maria Marjorette, Hogan, Kristen M, Baird, Maredith, Wilson, Kiesha, Nagarkatti, Prakash, Nagarkatti, Mitzi, Busbee, Philip Brandon

“…Colitis is an inflammatory bowel disease (IBD) characterized by immune cell dysregulation and alterations in the gut microbiome. In our previous report, we…”
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Endogenous Reverse Transcriptase Inhibition Attenuates TLR5-Mediated Inflammation by Dopkins, Nicholas, Singh, Bhavya, Michael, Stephanie, O'Mara, Morgan M, Marston, Jez L, Fei, Tongyi, Bendall, Matthew L, Nixon, Douglas F

“…Transposable elements (TEs) are mobile genomic sequences that encompass roughly 50% of the human genome. Class 1 TEs, or "retrotransposons," mobilize through…”
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Effects of Acute 2,3,7,8-Tetrachlorodibenzo-p-Dioxin Exposure on the Circulating and Cecal Metabolome Profile by Dopkins, Nicholas, Neameh, Wurood Hantoosh, Hall, Alina, Lai, Yunjia, Rutkovsky, Alex, Gandy, Alexa Orr, Lu, Kun, Nagarkatti, Prakash S, Nagarkatti, Mitzi

“…2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a polyhalogenated planar hydrocarbon belonging to a group of highly toxic and persistent environmental…”
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The brain-liver cholinergic anti-inflammatory pathway and viral infections by Martínez-Meza, Samuel, Singh, Bhavya, Nixon, Douglas F, Dopkins, Nicholas, Gangcuangco, Louie Mar A

“…Efferent cholinergic signaling is a critical and targetable source of immunoregulation. The vagus nerve (VN) is the primary source of cholinergic signaling in…”
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Yin and yang of cannabinoid CB1 receptor: CB1 deletion in immune cells causes exacerbation while deletion in non-immune cells attenuates obesity by Miranda, Kathryn, Becker, William, Busbee, Philip B., Dopkins, Nicholas, Abdulla, Osama A., Zhong, Yin, Zhang, Jiajia, Nagarkatti, Mitzi, Nagarkatti, Prakash S.

“…While blockade of cannabinoid receptor 1 (CB1) has been shown to attenuate diet-induced obesity (DIO), its relative role in different cell types has not been…”
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Activation of human endogenous retroviruses and its physiological consequences by Dopkins, Nicholas, Nixon, Douglas F.

“…Human endogenous retroviruses (HERVs) are abundant sequences that persist within the human genome as remnants of ancient retroviral infections. These sequences…”
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Two-step recognition of HIV-1 DNA in the cytosol by Dopkins, Nicholas, Nixon, Douglas F.

“…Retroviral DNA induces the production of interferons. A new study by Yoh et al. showed that the host factor ‘PQBP1’ primes immune-recognition of retroviral DNA…”
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Tryptamine treatment results in the amelioration of EAE by inducing an anti-inflammatory shift in the Th17/Treg balance mediated by regulation of miRNA expression profile by Dopkins, Nicholas, Nagarkatti, Prakash, Nagarkatti, Mitzi

“…Abstract In this study we focus on understanding the novel immunotherapeutic potential of tryptamine, a bioactive indole compound derived from microorganisms…”
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Effects of Orally Administered Cannabidiol on Neuroinflammation and Intestinal Inflammation in the Attenuation of Experimental Autoimmune Encephalomyelitis by Dopkins, Nicholas, Miranda, Kathryn, Wilson, Kiesha, Holloman, Bryan L., Nagarkatti, Prakash, Nagarkatti, Mitzi

“…Cannabidiol (CBD) is a bioactive compound isolated from Cannabis plants that has garnered attention within the medical community due to its potent…”
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I3C-MEDIATED PROTECTION AGAINST COLITIS DEPENDENT ON AHR EXPRESSION ON VIL1-EXPRESSING COLONIC EPITHELIAL CELLS by Saxena, Archana, Mitchell, Chandani, Wilson, Keisha, Rutkovsky, Alex, Wisniewski, PJ, Dopkins, Nicholas, Nagarkatti, Mitzi, Nagarkatti, Prakash, Busbee, Brandon

“…Abstract Many current treatments for ulcerative colitis (UC) often causes side effects warranting safe therapeutic strategies to control the pathogenesis of…”
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Efficacy of cannabidiol treatment in experimental MS is due to immunosuppressive activity of myeloid cells in CNS downregulating recruitment of CD4+ T cells, proinflammatory chemokines and gasdermin D expression by Dopkins, Nicholas, Wilson, Kiesha, Miranda, Kathryn, Nagarkatti, Prakash S, Nagarkatti, Mitzi

“…Abstract Cannabidiol (CBD) is a nonpsychoactive ingredient from Cannabis that has garnered attention in the medical community due to its anti-inflammatory…”
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A field guide to endogenous retrovirus regulatory networks by Dopkins, Nicholas, O’Mara, Morgan M., Lawrence, Elsa, Fei, Tongyi, Sandoval-Motta, Santiago, Nixon, Douglas F., Bendall, Matthew L.

“…Germ cells are subject to exogenous retrovirus infections occasionally resulting in the genomic integration of retroviral gene sequences. These endogenized…”
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Regulation of Inflammatory Processes by Tryptamine, Cannabidiol and 2,3,7,8-Tetrachlorodibenzo-p-Dioxin by Dopkins, Nicholas

“…Host immunity is a complicated system of pro-inflammatory and anti-inflammatory processes that respond to exogenous and endogenous threats to regulate host…”
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AhR expression on both Rorc-specific immune cells and Vil1-expressing colonic epithelial cells are essential for I3C-mediated protection against colitis by Mitchell, Chandani, Staley, Shanieka, Wilson, Keisha, Rutkovsky, Alex, Wisniewski, Pj, Dopkins, Nicholas, Nagarkatti, Mitzi, Nagarkatti, Prakash, Busbee, Philip B

“…Abstract Colitis is an inflammatory bowel disease (IBD) characterized by dysregulation of the immune system. In our previous reports, we showed…”
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How human endogenous retroviruses interact with the microbiota in health and disease by Dopkins, Nicholas, O’Mara, Morgan M., Singh, Bhavya, Marston, Jez L., Bendall, Matthew L., Nixon, Douglas F.

“…The microbiota is a collective of microorganisms whose composition is intimately linked with human health and disease. Emerging evidence demonstrates that…”
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AHR EXPRESSION ON VIL1-EXPRESSING COLONIC EPITHELIAL CELLS IS ESSENTIAL FOR I3C-MEDIATED PROTECTION AGAINST COLITIS by Saxena, Archana, Mitchell, Chandani, Stanley, Shanieka, Wilson, Keisha, Rutkovsky, Alex, Wisniewski, PJ, Dopkins, Nicholas, Nagarkatti, Mitzi, Nagarkatti, Prakash, Busbee, Philip

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