Search Results - "Dopico, Alejandro M"

Common structural features of cholesterol binding sites in crystallized soluble proteins by Bukiya, Anna N., Dopico, Alejandro M.

“…Cholesterol-protein interactions are essential for the architectural organization of cell membranes and for lipid metabolism. While cholesterol-sensing motifs…”
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steroid interaction site in transmembrane domain 2 of the large conductance, voltage- and calcium-gated potassium (BK) channel accessory β1 subunit by Bukiya, Anna N, Singh, Aditya K, Parrill, Abby L, Dopico, Alejandro M

“…Large conductance, voltage- and calcium-gated potassium (BK) channels regulate several physiological processes, including myogenic tone and thus, artery…”
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Heme Is a Carbon Monoxide Receptor for Large-Conductance Ca2+-Activated K+ Channels by Jaggar, Jonathan H, Li, Anlong, Parfenova, Helena, Liu, Jianxi, Umstot, Edward S, Dopico, Alejandro M, Leffler, Charles W

“…Carbon monoxide (CO) is an endogenous paracrine and autocrine gaseous messenger that regulates physiological functions in a wide variety of tissues. CO induces…”
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Ethanol modulates BKCa channels by acting as an adjuvant of calcium by Liu, Jianxi, Vaithianathan, Thirumalini, Manivannan, Kandiah, Parrill, Abby, Dopico, Alejandro M

“…Ethanol modulation of calcium- and voltage-gated potassium (slo1) channels alters neuronal excitability, cerebrovascular tone, brain function, and behavior,…”
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Cholesterol antagonizes ethanol potentiation of human brain BKCa channels reconstituted into phospholipid bilayers by Crowley, John J, Treistman, Steven N, Dopico, Alejandro M

“…The activity of large conductance, Ca2+-sensitive K+ (BKCa) channels, known to control neuronal excitability, is increased by ethanol (EtOH) exposure…”
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A Novel CaV1.2 N Terminus Expressed in Smooth Muscle Cells of Resistance Size Arteries Modifies Channel Regulation by Auxiliary Subunits by Cheng, Xiaoyang, Liu, Jianxi, Asuncion-Chin, Maria, Blaskova, Eva, Bannister, John P., Dopico, Alejandro M., Jaggar, Jonathan H.

“…Voltage-dependent L-type Ca2+ (CaV1.2) channels are the principal Ca2+ entry pathway in arterial myocytes. CaV1.2 channels regulate multiple vascular functions…”
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Essential Role for Smooth Muscle BK Channels in Alcohol-Induced Cerebrovascular Constriction by Liu, Pengchong, Xi, Qi, Ahmed, Abu, Jaggar, Jonathan H, Dopico, Alejandro M

“…Binge drinking is associated with increased risk for cerebrovascular spasm and stroke. Acute exposure to ethanol at concentrations obtained during binge…”
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Distinct structural features of phospholipids differentially determine ethanol sensitivity and basal function of BK channels by Crowley, John J, Treistman, Steven N, Dopico, Alejandro M

“…Large conductance Ca2+ -activated K+ (BK) channel activity and its potentiation by ethanol are both critically modulated by bilayer phosphatidylserine (PS), a…”
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Large conductance, calcium- and voltage-gated potassium (BK) channels: regulation by cholesterol by Dopico, Alejandro M, Bukiya, Anna N, Singh, Aditya K

“…Cholesterol (CLR) is an essential component of eukaryotic plasma membranes. CLR regulates the membrane physical state, microdomain formation and the activity…”
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Partial eNOS deficiency causes spontaneous thrombotic cerebral infarction, amyloid angiopathy and cognitive impairment by Tan, Xing-Lin, Xue, Yue-Qiang, Ma, Tao, Wang, Xiaofang, Li, Jing Jing, Lan, Lubin, Malik, Kafait U, McDonald, Michael P, Dopico, Alejandro M, Liao, Francesca-Fang

“…Cerebral infarction due to thrombosis leads to the most common type of stroke and a likely cause of age-related cognitive decline and dementia. Endothelial…”
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Dietary Cholesterol Protects Against Alcohol-Induced Cerebral Artery Constriction by Bukiya, Anna, Dopico, Alejandro M., Leffler, Charles W., Fedinec, Alexander

“…Background Binge drinking represents the major form of excessive alcohol (ethanol [EtOH]) consumption in the United States. Episodic (such as binge) drinking…”
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Large conductance, calcium- and voltage-gated potassium (BK) channels: Regulation by cholesterol by Dopico, Alejandro M., Bukiya, Anna N., Singh, Aditya K.

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Rat supraoptic magnocellular neurones show distinct large conductance, Ca2+-activated K+ channel subtypes in cell bodies versus nerve endings by Dopico, Alejandro M., Widmer, Hélène, Wang, Gang, Lemos, José R., Treistman, Steven N.

“…Large conductance, Ca 2+ -activated K + (BK) channels were identified in freshly dissociated rat supraoptic neurones using patch clamp techniques. The single…”
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The steroid interaction site in transmembrane domain 2 of the large conductance, voltage- and calcium-gated potassium (BK) channel accessory beta 1 subunit by Bukiya, Anna N, Singh, Aditya K, Parrill, Abby L, Dopico, Alejandro M

“…Large conductance, voltage- and calcium-gated potassium (BK) channels regulate several physiological processes, including myogenic tone and thus, artery…”
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Integrated channel plasticity contributes to alcohol tolerance in neurohypophysial terminals by Knott, Thomas K, Dopico, Alejandro M, Dayanithi, Govindan, Lemos, José, Treistman, Steven N

“…Short-term ethanol challenge results in the reduction of peptide hormone release from the rat neurohypophysis. However, rats that have been maintained on an…”
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The second transmembrane domain of the large conductance, voltage- and calcium-gated potassium channel beta(1) subunit is a lithocholate sensor by Bukiya, Anna N, Vaithianathan, Thirumalini, Toro, Ligia, Dopico, Alejandro M

“…Bile acids and other steroids modify large conductance, calcium- and voltage-gated potassium (BK) channel activity contributing to non-genomic modulation of…”
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Subtype identification and functional characterization of ryanodine receptors in rat cerebral artery myocytes by Vaithianathan, Thirumalini, Narayanan, Damodaran, Asuncion-Chin, Maria T, Jeyakumar, Loice H, Liu, Jianxi, Fleischer, Sidney, Jaggar, Jonathan H, Dopico, Alejandro M

“…Ryanodine receptors (RyRs) regulate contractility in resistance-size cerebral artery smooth muscle, yet their molecular identity, subcellular location, and…”
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Ethanol Interactions With Calcium-Dependent Potassium Channels by Brodie, Mark S., Scholz, Andreas, Weiger, Thomas M., Dopico, Alejandro M.

“…In most neurons and other excitable cells, calcium‐activated potassium channels of small (SK) and large conductance (BK; MaxiK) control excitability and…”
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Alternative splicing of Cav1.2 channel exons in smooth muscle cells of resistance-size arteries generates currents with unique electrophysiological properties by Cheng, Xiaoyang, Pachuau, Judith, Blaskova, Eva, Asuncion-Chin, Maria, Liu, Jianxi, Dopico, Alejandro M, Jaggar, Jonathan H

“…Voltage-dependent calcium (Ca(2+), Ca(V)1.2) channels are the primary Ca(2+) entry pathway in smooth muscle cells of resistance-size (myogenic) arteries, but…”
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Sizing up Ethanol-Induced Plasticity: The Role of Small and Large Conductance Calcium-Activated Potassium Channels by Mulholland, Patrick J., Hopf, F. Woodward, Bukiya, Anna N., Martin, Gilles E., Liu, Jianxi, Dopico, Alejandro M., Bonci, Antonello, Treistman, Steven N., Chandler, L. Judson

“…Small (SK) and large conductance (BK) Ca2+‐activated K+ channels contribute to action potential repolarization, shape dendritic Ca2+spikes and postsynaptic…”
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