Effect of thymoquinone on the lung pathology and cytokine levels of ovalbumin-sensitized guinea pigs

Effect of thymoquinone on the lung pathology and cytokine levels of ovalbumin-sensitized guinea pigs

Different pharmacological effects from Nigella sativa have been demonstrated in guinea pig tracheal chains in previous studies. In the present study, the prophylactic effects of thymoquinone on lung pathology as well as blood IL-4 and IFN-γ levels in sensitized guinea pigs were examined. Three group...

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Bibliographic Details
Published in:Pharmacological reports Vol. 62; no. 5; pp. 910 - 916
Main Authors: Keyhanmanesh, Rana, Boskabady, Mohammad H., Khamneh, Saeed, Doostar, Yoosef
Format: Journal Article
Language:English
Published: Cham Elsevier Urban & Partner Sp. z o.o 01-09-2010
Springer International Publishing
Subjects:
Animals
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Asthma
Benzoquinones - pharmacology
Benzoquinones - therapeutic use
Cytokines
Drug Safety and Pharmacovigilance
Female
Guinea Pigs
Inflammation
Interferon-gamma - blood
Interleukin-4 - blood
Lung - drug effects
Lung - immunology
Lung - pathology
Male
Nigella sativa
Ovalbumin
pathological changes
Pharmacotherapy
Pharmacy
Pneumonia - blood
Pneumonia - pathology
Pneumonia - prevention & control
Sensitization
Thymoquinone
Sensitization
Inflammation
Cytokines
Thymoquinone
Asthma
pathological changes
thymoquinone
asthma
cytokines
sensitization
inflammation
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Summary:Different pharmacological effects from Nigella sativa have been demonstrated in guinea pig tracheal chains in previous studies. In the present study, the prophylactic effects of thymoquinone on lung pathology as well as blood IL-4 and IFN-γ levels in sensitized guinea pigs were examined. Three groups of guinea pigs sensitized to ovalbumin were given drinking water alone (group S) or drinking water containing low (LTQ) or high (HTQ) concentrations of thymoquinone (groups S+LTQ and S+HTQ). The lung pathology as well as blood IL-4 and IFN-γ levels of the sensitized and the control guinea pigs were evaluated in three sensitized and one control group (n=8, for all groups). The lungs of the S group showed significant pathological changes (p<0.001). Blood IL-4 and IFN-γ levels were increased in the sensitized animals compared to those of controls (p<0.01 and p<0.001, respectively). Treatment of the S animals with thymoquinone significantly improved their pathological changes to the lung and decreased their IL-4 levels (p<0.05 to p<0.001) but increased their IFN-γ levels (p<0.001). These results showed a preventive effect of thymoquinone on lung inflammation in sensitized guinea pigs.
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ISSN:1734-1140
2299-5684
DOI:10.1016/S1734-1140(10)70351-0