Search Results - "Doorduijn, Elien"

The urgent need to recover MHC class I in cancers for effective immunotherapy by Garrido, Federico, Aptsiauri, Natalia, Doorduijn, Elien M, Garcia Lora, Angel M, van Hall, Thorbald

“…Highlights • Tumor immune escape compromises the efficacy of cancer immunotherapy. • Loss of MHC class I expression is a frequent event in cancer cells. •…”
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Tumor-targeted silencing of the peptide transporter TAP induces potent antitumor immunity by Garrido, Greta, Schrand, Brett, Rabasa, Ailem, Levay, Agata, D’Eramo, Francesca, Berezhnoy, Alexey, Modi, Shrey, Gefen, Tal, Marijt, Koen, Doorduijn, Elien, Dudeja, Vikas, van Hall, Thorbald, Gilboa, Eli

“…Neoantigen burden is a major determinant of tumor immunogenicity, underscored by recent clinical experience with checkpoint blockade therapy. Yet the majority…”
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TEIPP antigens for T-cell based immunotherapy of immune-edited HLA class Ilow cancers by Marijt, Koen A., Doorduijn, Elien M., van Hall, Thorbald

“…•Downregulation of MHC-I expression common method by which tumors evade immune recognition.•Alternative peptide repertoire presented on cells with defect in…”
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TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors by Doorduijn, Elien M, Sluijter, Marjolein, Querido, Bianca J, Oliveira, Cláudia C, Achour, Adnane, Ossendorp, Ferry, van der Burg, Sjoerd H, van Hall, Thorbald

“…Tumor cells frequently escape from CD8+ T cell recognition by abrogating MHC-I antigen presentation. Deficiency in processing components, like the transporter…”
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Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicity by Punt, Simone, Malu, Shruti, McKenzie, Jodi A., Manrique, Soraya Zorro, Doorduijn, Elien M., Mbofung, Rina M., Williams, Leila, Silverman, Deborah A., Ashkin, Emily L., Dominguez, Ana Lucía, Wang, Zhe, Chen, Jie Qing, Maiti, Sourindra N., Tieu, Trang N., Liu, Chengwen, Xu, Chunyu, Forget, Marie-Andrée, Haymaker, Cara, Khalili, Jahan S., Satani, Nikunj, Muller, Florian, Cooper, Laurence J. N., Overwijk, Willem W., Amaria, Rodabe N., Bernatchez, Chantale, Heffernan, Timothy P., Peng, Weiyi, Roszik, Jason, Hwu, Patrick

“…Although immunotherapy has achieved impressive durable clinical responses, many cancers respond only temporarily or not at all to immunotherapy. To find novel,…”
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CD4 + T Cell and NK Cell Interplay Key to Regression of MHC Class I low Tumors upon TLR7/8 Agonist Therapy by Doorduijn, Elien M, Sluijter, Marjolein, Salvatori, Daniela C, Silvestri, Serenella, Maas, Saskia, Arens, Ramon, Ossendorp, Ferry, van der Burg, Sjoerd H, van Hall, Thorbald

“…One of the next challenges in cancer immunotherapy is the resistance of tumors to T-cell-based treatments through loss of MHC class I. Here, we show that under…”
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T cells specific for a TAP-independent self-peptide remain naïve in tumor-bearing mice and are fully exploitable for therapy by Doorduijn, Elien M., Sluijter, Marjolein, Marijt, Koen A., Querido, Bianca J., van der Burg, Sjoerd H., van Hall, Thorbald

“…Cancers frequently evade immune-recognition by lowering peptide:MHC-I complexes on their cell surface. Limited peptide supply due to TAP-deficiency results in…”
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The Immunogenicity of a Proline-Substituted Altered Peptide Ligand toward the Cancer-Associated TEIPP Neoepitope Trh4 Is Unrelated to Complex Stability by Hafstrand, Ida, Doorduijn, Elien M, Sun, Renhua, Talyzina, Anna, Sluijter, Marjolein, Pellegrino, Sara, Sandalova, Tatyana, Duru, Adil Doganay, van Hall, Thorbald, Achour, Adnane

“…Human cancers frequently display defects in Ag processing and presentation allowing for immune evasion, and they therefore constitute a significant challenge…”
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The MHC Class I Cancer-Associated Neoepitope Trh4 Linked with Impaired Peptide Processing Induces a Unique Noncanonical TCR Conformer by Hafstrand, Ida, Doorduijn, Elien M, Duru, Adil Doganay, Buratto, Jeremie, Oliveira, Claudia Cunha, Sandalova, Tatyana, van Hall, Thorbald, Achour, Adnane

“…MHC class I downregulation represents a significant challenge for successful T cell-based immunotherapy. T cell epitopes associated with impaired peptide…”
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Limited density of an antigen presented by RMA-S cells requires B7-1/CD28 signaling to enhance T-cell immunity at the effector phase by Li, Xiao-Lin, Sluijter, Marjolein, Doorduijn, Elien M, Kale, Shubha P, McFerrin, Harris, Liu, Yong-Yu, Li, Yan, Mottamal, Madhusoodanan, Yao, Xin, Du, Fengkun, Gu, Baihan, Hoang, Kim, Nguyen, Yen H, Taylor, Nichelle, Stephens, Chelsea R, van Hall, Thorbald, Zhang, Qian-Jin

“…The association of B7-1/CD28 between antigen presenting cells (APCs) and T-cells provides a second signal to proliferate and activate T-cell immunity at the…”
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T Cells Engaging the Conserved MHC Class Ib Molecule Qa-1b with TAP-Independent Peptides Are Semi-Invariant Lymphocytes by Doorduijn, Elien M., Sluijter, Marjolein, Querido, Bianca J., Seidel, Ursula J. E., Oliveira, Claudia C., van der Burg, Sjoerd H., van Hall, Thorbald

“…The HLA-E homolog in the mouse (Qa-1b) is a conserved MHC class Ib molecule presenting monomorphic peptides to germline-encoded natural killer receptor…”
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The Thirteenth International Conference on Progress in Vaccination Against Cancer (PIVAC-13), October 2–4, 2013, Amsterdam, The Netherlands: the current standing of anti-tumor immunotherapeutic approaches by Melief, Sara M., Visconti, Valeria V., Doorduijn, Elien M., Santegoets, Saskia J. A. M.

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TEIPP antigens for T-cell based immunotherapy of immune-edited HLA class I low cancers by Marijt, Koen A, Doorduijn, Elien M, van Hall, Thorbald

“…T-cell based immunotherapies through checkpoint blockade or adoptive transfer are effective treatments for a wide range of cancers like melanomas and lung…”
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IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4+ T cells by inducing Blimp1 by Heinemann, Christina, Heink, Sylvia, Petermann, Franziska, Vasanthakumar, Ajithkumar, Rothhammer, Veit, Doorduijn, Elien, Mitsdoerffer, Meike, Sie, Christopher, da Costa, Olivia Prazeres, Buch, Thorsten, Hemmer, Bernhard, Oukka, Mohamed, Kallies, Axel, Korn, Thomas

“…Central nervous system (CNS) autoimmunity is regulated by the balance of pro-inflammatory cytokines and IL-10. Here we identify the transcriptional regulator…”
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Abstract 264: Vaccination against neoantigens induced in future tumors in the setting of recurrence and premalignancy by Hidalgo, Greta Garrido, Schrand, Brett, Rabasa, Ailem, Levay, Agata, Berezhnoy, Alexey, Modi, Shrey, Bhuwan, Giri Bhuwan, Dudeja, Vikas, Doorduijn, Elien, Hall, Thorbald van, Gilboa, Eli

“…Development of therapeutic strategies to prevent recurrence in cancer patients, or tumor progression in at risk individuals has been challenging given the long…”
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1462 Adrenergic signaling augments cytotoxic T cell anti tumor activity in p53 deficient cancers by CXCL10 release by Silverman, Deborah, Leahey, DSara, Akhter, Shamima, Xie, Tong, Anfossi, Simone, Covello, Jennifer, Netto, Frederico, Doorduijn, Elien, Wang, Yunfei, Ashkin, Emily, Myers, Jeffrey, Calin, George, Hwu, Patrick, Moran, Amit

“…BackgroundHarnessing the immune system through the attenuation of immune checkpoints has led to durable tumor rejection in a subset of tumors. However, the…”
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Abstract PO-076: Adrenergic regulation of the anti-tumor immune response in p53 -deficient tumors by Silverman, Deborah A., Akhter, Shamima, Xie, Tongxin, Islam, Shajedul, Anfossi, Simone, Covello, Jennifer D., Gleber-Netto, Frederico O., Doorduijn, Elien, Wang, Yunfei, Ashkin, Emily L., Myers, Jeffrey N., Calin, George A., Hwu, Patrick, Amit, Moran

“…Several previous studies have shown that β2-adrenergic signaling pathway promotes tumor progression, whereas others have shown the opposite effect. The role of…”
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TAP-independent self-peptides enhance T cell recognition of immune-escaped tumors by Doorduijn, Elien M, Sluijter, Marjolein, Querido, Bianca J, Oliveira, Cláudia C, Achour, Adnane, Ossendorp, Ferry, van der Burg, Sjoerd H, van Hall, Thorbald

“…Tumor cells frequently escape from CD8+ T cell recognition by abrogating MHC-I antigen presentation. Deficiency in processing components, like the transporter…”
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T Cells Engaging the Conserved MHC Class Ib Molecule Qa-1 b with TAP-Independent Peptides Are Semi-Invariant Lymphocytes by Doorduijn, Elien M, Sluijter, Marjolein, Querido, Bianca J, Seidel, Ursula J E, Oliveira, Claudia C, van der Burg, Sjoerd H, van Hall, Thorbald

“…The HLA-E homolog in the mouse (Qa-1 ) is a conserved MHC class Ib molecule presenting monomorphic peptides to germline-encoded natural killer receptor…”
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Tumors with processing defects display novel tumor antigens via the non-classical HLA-E by Elien, Doorduijn, Claudia, Cunha Oliveira, Bianca, Querido, Marjolein, Sluijter, Thorbald, Van Hall

“…Abstract only…”
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