Search Results - "Doolittle, Russell"

The conversion of fibrinogen to fibrin: A brief history of some key events by Doolittle, Russell F.

“…The conversion of fibrinogen to fibrin is a process that has long fascinated an army of researchers. In this brief review some early break-through observations…”
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S. Jonathan Singer: A man who loved ideas and detested walls by Doolittle, Russell F.

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Clotting of Mammalian Fibrinogens by Papain: A Re-examination by Doolittle, Russell F

“…Papain has long been known to cause the gelation of mammalian fibrinogens. It has also been reported that papain-fibrin is insoluble in dispersing solvents…”
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Bioinformatic Characterization of Genes and Proteins Involved in Blood Clotting in Lampreys by Doolittle, Russell F.

“…Lampreys and hagfish are the earliest diverging of extant vertebrates and are obvious targets for investigating the origins of complex biochemical systems…”
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Crystal Structure of Human Fibrinogen by Kollman, Justin M, Pandi, Leela, Sawaya, Michael R, Riley, Marcia, Doolittle, Russell F

“…A crystal structure of human fibrinogen has been determined at approximately 3.3 Å resolution. The protein was purified from human blood plasma, first by a…”
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Correlating structure and function during the evolution of fibrinogen‐related domains by Doolittle, Russell F., McNamara, Kyle, Lin, Kevin

“…Fibrinogen‐related domains (FReDs) are found in a variety of animal proteins with widely different functions, ranging from non‐self recognition to clot…”
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Coagulation in Vertebrates with a Focus on Evolution and Inflammation by Doolittle, Russell F.

“…The evolution of a thrombin-generating system that produces a gelatinous clot to prevent the loss of blood occurred in parallel with the evolution of…”
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Some Important Milestones in the Field of Blood Clotting by Doolittle, Russell F.

“…Several different kinds of ‘milestone' in the field of blood coagulation are described from the middle decades of the 20th century. Although viewed from the…”
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TRF2 and the evolution of the bilateria by Duttke, Sascha H C, Doolittle, Russell F, Wang, Yuan-Liang, Kadonaga, James T

“…The development of a complex body plan requires a diversity of regulatory networks. Here we consider the concept of TATA-box-binding protein (TBP) family…”
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Phylogeny Determined by Protein Domain Content by Yang, Song, Doolittle, Russell F., Bourne, Philip E.

“…A simple classification scheme that uses only the presence or absence of a protein domain architecture has been used to determine the phylogeny of 174 complete…”
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Clots vs bugs: who's ahead? by Doolittle, Russell F.

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The roots of bioinformatics in protein evolution by Doolittle, Russell F

“…  A related compound phenylisocyanate (PheNCO) had previously been shown to be a labilizing agent that could tag and release an amino acid from the…”
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Genomic Evidence for a Simpler Clotting Scheme in Jawless Vertebrates by Doolittle, Russell F, Jiang, Yong, Nand, Justin

“…Mammalian blood clotting involves numerous components, most of which are the result of gene duplications that occurred early in vertebrate evolution and after…”
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The Evolution of Vertebrate Blood Coagulation as Viewed from a Comparison of Puffer Fish and Sea Squirt Genomes by Jiang, Yong, Doolittle, Russell F.

“…The blood coagulation scheme for the puffer fish, Fugu rubripes, has been reconstructed on the basis of orthologs of genes for mammalian blood clotting factors…”
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Searching for differences between fibrinogen and fibrin that affect the initiation of fibrinolysis by Doolittle, Russell F

“…Although in a gross sense fibrin is merely a collection of fibrinogen molecules packed together in bundles, numerous small structural differences can arise as…”
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The Protochordate Ciona intestinalis Has a Protein Like Full-Length Vertebrate Fibrinogen by Doolittle, Russell F.

“…In a recent review, a putative fibrinogen-like protein in the protochordate Ciona intestinalis was noted. Unfortunately, computer-directed splicing had omitted…”
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A Model of Fibrin Formation Based on Crystal Structures of Fibrinogen and Fibrin Fragments Complexed with Synthetic Peptides by Yang, Z, Mochalkin, I, Doolittle, R F

“…A blood clot is a meshwork of fibrin fibers built up by the systematic assembly of fibrinogen molecules proteolyzed by thrombin. Here, we describe a model of…”
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Microbial genomes multiply by Doolittle, Russell F

“…It is seven years since the first bacterial genome was completely sequenced, and more than 60 others have now been determined. Doolittle discusses what the…”
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Peptide-Derivatized Albumins That Inhibit Fibrin Polymerization by Watson, Joseph W, Doolittle, Russell F

“…Synthetic peptides patterned on sequences that appear during thrombin proteolysis of fibrinogen are known to influence fibrin formation in very different ways…”
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Probing the β-Chain Hole of Fibrinogen with Synthetic Peptides That Differ at Their Amino Termini by Doolittle, Russell F, Pandi, Leela

“…In a recent report, we showed that alanine can replace glycine at the amino terminus of synthetic B-knobs that bind to human fibrin(ogen). We now report a…”
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