Search Results - "Doolan, Kyle"

Conformation-Dependent Epitopes Recognized by Prion Protein Antibodies Probed Using Mutational Scanning and Deep Sequencing by Doolan, Kyle M., Colby, David W.

“…Prion diseases are caused by a structural rearrangement of the cellular prion protein, PrPC, into a disease-associated conformation, PrPSc, which may be…”
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Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape by Ku, Zhiqiang, Xie, Xuping, Davidson, Edgar, Ye, Xiaohua, Su, Hang, Menachery, Vineet D., Li, Yize, Yuan, Zihao, Zhang, Xianwen, Muruato, Antonio E., i Escuer, Ariadna Grinyo, Tyrell, Breanna, Doolan, Kyle, Doranz, Benjamin J., Wrapp, Daniel, Bates, Paul F., McLellan, Jason S., Weiss, Susan R., Zhang, Ningyan, Shi, Pei-Yong, An, Zhiqiang

“…Antibody cocktails represent a promising approach to prevent SARS-CoV-2 escape. The determinants for selecting antibody combinations and the mechanism that…”
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Author Correction: Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape by Ku, Zhiqiang, Xie, Xuping, Davidson, Edgar, Ye, Xiaohua, Su, Hang, Menachery, Vineet D., Li, Yize, Yuan, Zihao, Zhang, Xianwen, Muruato, Antonio E., i Escuer, Ariadna Grinyo, Tyrell, Breanna, Doolan, Kyle, Doranz, Benjamin J., Wrapp, Daniel, Bates, Paul F., McLellan, Jason S., Weiss, Susan R., Zhang, Ningyan, Shi, Pei-Yong, An, Zhiqiang

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1182 Bispecific GPRC5D antibodies with potent cell-killing activity against multiple myeloma by Roth, Hayley, Sanchez, Ileine, Tyrell, Breanna, Lobley, Anna, Barnes, Trevor, Cunningham, Alyssa, Nwogu, Nnenna, Doolan, Kyle, Doranz, Benjamin, Rucker, Joseph, Chambers, Ross

“…BackgroundGPRC5D is a G protein-coupled receptor that is expressed on multiple myeloma cells but absent from most healthy tissues except for hair follicles…”
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1183 Development of CTIM-76, a highly specific Claudin 6 bispecific antibody by Rucker, Joseph, Sanchez, Ileine, Doolan, Kyle, Tyrell, Breanna, Lobley, Anna, Molino, Nicholas, Shema, Kristin, Guldner, Kyle, Roth, Hayley, Cunningham, Alyssa, Slovik, Kate, Butz, Eric, Roberts, Stanley, Byrnes-Blake, Kelly, Payne, Riley, Calamai, Ed, Chambers, Ross

“…BackgroundCTIM-76 is a bispecific Claudin 6 (CLDN6) T-cell engager antibody in preclinical development for treatment of CLDN6-positive cancers, including…”
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Abstract 2374: Bispecific and trispecific GPRC5D antibodies with potent cell-killing activity against multiple myeloma by Roth, Hayley, Rogers, Daniel, Sanchez, Ileine, Tyrell, Breanna, Barnes, Trevor, Snyder, Ami, Nowgu, Nenna, Doolan, Kyle, Doranz, Benjamin J., Chambers, Ross, Rucker, Joseph B.

“…Abstract Background: GPRC5D is a G protein-coupled receptor that is expressed on multiple myeloma cells but absent from most healthy tissues except for hair…”
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Abstract 2892: Development of claudin 6 bispecific antibodies for treatment of ovarian cancer by Rucker, Joseph, Doolan, Kyle, Tyrell, Breanna, Lobley, Anna, Molino, Nick, Shema, Kristen, Guldner, Kyle, Cunningham, Alyssa, Chambers, Ross, Payne, Riley

“…Abstract There is growing interest in applying antibody modalities including bispecifics, antibody-drug conjugates, and CART to solid tumors. However,…”
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Abstract 1865: Development of CTIM-76, a highly specific Claudin 6 bispecific antibody for treatment of ovarian cancer by Rucker, Joseph, Sanchez, Ileine, Doolan, Kyle, Tyrell, Breanna, Lobley, Anna, Molino, Nicholas, Shema, Kristen, Guldner, Kyle, Roth, Hayley, Cunningham, Alyssa, Slovik, Kate, Payne, Riley, Butz, Eric, Dick, Evan, Calamai, Edward, Chambers, Ross

“…Abstract Solid tumors lead to 580,000 deaths annually in the US, and safe and effective therapeutics for many late-stage solid tumors are lacking. Ovarian…”
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Abstract 6305: Bispecific claudin 18.2 and GPRC5D antibodies with potent cell-killing activity for cancer therapeutics by Sanchez, Ileine, Roth, Hayley, Screnci, Brad, Tucker, David, Molino, Nick, Barnes, Trevor, Murphy, Paige, Guldner, Kyle, Phillips, Tim, Shema, Kristen, Charpentier, Thomas, Cunningham, Alyssa, Latta, Janae, Tyrell, Breanna, Pitts, Meghan, Navia, Carmen, Azuelos, Charles, Lobley, Anna, Karam, Jawhara, Fiers, Valerie, Reyes, Daniela, Slovik, Kate, Snyder, Alison, Assogba, Marianne, Chang, Kai-Ti, Payne, Riley, Doolan, Kyle, Chambers, Ross, Rucker, Joe, Doranz, Benjamin

“…Abstract Tumor-associated antigens with little or no expression in healthy tissue are attractive targets for anti-tumor modalities including T cell-engaging…”
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Abstract 1543: Discovery of CCR8 antibodies targeting regulatory T cells to enable tumor sensitization by Screnci, Brad, Roth, Hayley, Campbell, Sarah, Tucker, David, Fenn-Ulke, Colleen, Rosenberg, Erin, Pitts, Meghan, Saint-Jean, Naomi, Karam, Jawhara, Murphy, Paige, Reyes, Daniela, Latta, Janae, Guldner, Kyle, Gilman, Samantha, Phillips, Tim, Stafford, L. Joe, Tyrell, Breanna, Shema, Kristen, Sulli, Chidananda, Molino, Nick, Snyder, Allison, Assogba, Marianne, Shah, Janvi, Zimmerman, McKayla, Barnes, Trevor, Payne, Riley, Cunningham, Alyssa, Charrier, Elisabeth, Ohl, Holden, Doolan, Kyle, Sanchez, Ileine, Rucker, Joseph B., Chambers, Ross, Doranz, Benjamin

“…Abstract Regulatory T (Treg) cells in the tumor microenvironment have an immune suppressive function, and their presence is associated with poor prognosis…”
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