Search Results - "Donovan, Jesse"

Rapid RNase L-driven arrest of protein synthesis in the dsRNA response without degradation of translation machinery by Donovan, Jesse, Rath, Sneha, Kolet-Mandrikov, David, Korennykh, Alexei

“…Mammalian cells respond to double-stranded RNA (dsRNA) by activating a translation-inhibiting endoribonuclease, RNase L. Consensus in the field indicates that…”
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Structural basis for cytosolic double-stranded RNA surveillance by human oligoadenylate synthetase 1 by Donovan, Jesse, Dufner, Matthew, Korennykh, Alexei

“…The human sensor of double-stranded RNA (dsRNA) oligoadenylate synthetase 1 (hOAS1) polymerizes ATP into 2′,5′-linked iso-RNA (2-5A) involved in innate…”
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Structural mechanism of sensing long dsRNA via a noncatalytic domain in human oligoadenylate synthetase 3 by Donovan, Jesse, Whitney, Gena, Rath, Sneha, Korennykh, Alexei

“…The mammalian innate immune system uses several sensors of double-stranded RNA (dsRNA) to develop the interferon response. Among these sensors are…”
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Structure of Human RNase L Reveals the Basis for Regulated RNA Decay in the IFN Response by Han, Yuchen, Donovan, Jesse, Rath, Sneha, Whitney, Gena, Chitrakar, Alisha, Korennykh, Alexei

“…One of the hallmark mechanisms activated by type I interferons (IFNs) in human tissues involves cleavage of intracellular RNA by the kinase homology…”
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Concerted 2-5A-Mediated mRNA Decay and Transcription Reprogram Protein Synthesis in the dsRNA Response by Rath, Sneha, Prangley, Eliza, Donovan, Jesse, Demarest, Kaitlin, Wingreen, Ned S., Meir, Yigal, Korennykh, Alexei

“…Viral and endogenous double-stranded RNA (dsRNA) is a potent trigger for programmed RNA degradation by the 2-5A/RNase L complex in cells of all mammals. This…”
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Human RNase L tunes gene expression by selectively destabilizing the microRNA-regulated transcriptome by Rath, Sneha, Donovan, Jesse, Whitney, Gena, Chitrakar, Alisha, Wang, Wei, Korennykh, Alexei

“…Double-stranded RNA (dsRNA) activates the innate immune system of mammalian cells and triggers intracellular RNA decay by the pseudokinase and endoribonuclease…”
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Ribonuclease L mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line by Li, Yize, Banerjee, Shuvojit, Goldstein, Stephen A, Dong, Beihua, Gaughan, Christina, Rath, Sneha, Donovan, Jesse, Korennykh, Alexei, Silverman, Robert H, Weiss, Susan R

“…ADAR1 isoforms are adenosine deaminases that edit and destabilize double-stranded RNA reducing its immunostimulatory activities. Mutation of leads to a severe…”
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Selenocysteine insertion sequence binding protein 2L is implicated as a novel post-transcriptional regulator of selenoprotein expression by Donovan, Jesse, Copeland, Paul R

“…The amino acid selenocysteine (Sec) is encoded by UGA codons. Recoding of UGA from stop to Sec requires a Sec insertion sequence (SECIS) element in the 3' UTR…”
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Innate Immune Messenger 2-5A Tethers Human RNase L into Active High-Order Complexes by Han, Yuchen, Whitney, Gena, Donovan, Jesse, Korennykh, Alexei

“…2′,5′-linked oligoadenylates (2-5As) serve as conserved messengers of pathogen presence in the mammalian innate immune system. 2-5As induce self-association…”
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Evolutionary history of selenocysteine incorporation from the perspective of SECIS binding proteins by Donovan, Jesse, Copeland, Paul R

“…The co-translational incorporation of selenocysteine into nascent polypeptides by recoding the UGA stop codon occurs in all domains of life. In eukaryotes,…”
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A mutation in the viral sensor 2'-5'-oligoadenylate synthetase 2 causes failure of lactation by Oakes, Samantha R, Gallego-Ortega, David, Stanford, Prudence M, Junankar, Simon, Au, Wendy Wing Yee, Kikhtyak, Zoya, von Korff, Anita, Sergio, Claudio M, Law, Andrew M K, Castillo, Lesley E, Allerdice, Stephanie L, Young, Adelaide I J, Piggin, Catherine, Whittle, Belinda, Bertram, Edward, Naylor, Matthew J, Roden, Daniel L, Donovan, Jesse, Korennykh, Alexei, Goodnow, Christopher C, O'Bryan, Moira K, Ormandy, Christopher J

“…We identified a non-synonymous mutation in Oas2 (I405N), a sensor of viral double-stranded RNA, from an ENU-mutagenesis screen designed to discover new genes…”
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A Novel Protein Domain Induces High Affinity Selenocysteine Insertion Sequence Binding and Elongation Factor Recruitment by Donovan, Jesse, Caban, Kelvin, Ranaweera, Ruchira, Gonzalez-Flores, Jonathan N., Copeland, Paul R.

“…Selenocysteine (Sec) is incorporated at UGA codons in mRNAs possessing a Sec insertion sequence (SECIS) element in their 3′-untranslated region. At least three…”
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Threading the needle: getting selenocysteine into proteins by Donovan, Jesse, Copeland, Paul R

“…The co-translational incorporation of selenocysteine (Sec) requires that UGA be recognized as a sense rather than a nonsense codon. This is accomplished by the…”
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Real-time 2-5A kinetics suggest that interferons β and λ evade global arrest of translation by RNase L by Chitrakar, Alisha, Rath, Sneha, Donovan, Jesse, Demarest, Kaitlin, Li, Yize, Sridhar, Raghavendra Rao, Weiss, Susan R., Kotenko, Sergei V., Wingreen, Ned S., Korennykh, Alexei

“…Cells of all mammals recognize double-stranded RNA (dsRNA) as a foreign material. In response, they release interferons (IFNs) and activate a ubiquitously…”
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The Efficiency of Selenocysteine Incorporation Is Regulated by Translation Initiation Factors by Donovan, Jesse, Copeland, Paul R.

“…Selenocysteine (Sec) incorporation is an essential process required for the production of at least 25 human selenoproteins. This unique amino acid is…”
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Dissescting the role of SBP2 in selenocysteine incorporation by Donovan, Jesse, Caban, Kelvin, Copeland, Paul R

“…Abstract only The SECIS binding protein, SBP2, is required for the co‐translational incorporation of selenocysteine (Sec) at specific UGA codons. The…”
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A birth‐to‐death view of mRNA from the RNA recognition motif perspective by Kinzy, Terri Goss, De Stefano, Lauren A., Esposito, Anthony M., Hurley, Jennifer M., Roy, Rohini, Valentin‐Acevedo, Anibal J., Chang, Kai‐Hsiung, Davila, Jonathan, Defren, Jennifer M., Donovan, Jesse, Irizarry‐Barreto, Patricia, Soto, Anibal, Ysla, Riza M., Copeland, H. Liesel, Copeland, Paul R.

“…RNA binding proteins are a large and varied group of factors that are the driving force behind post‐transcriptional gene regulation. By analogy with…”
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