Search Results - "Donovan, Benjamin T"

Dissociation rate compensation mechanism for budding yeast pioneer transcription factors by Donovan, Benjamin T, Chen, Hengye, Jipa, Caroline, Bai, Lu, Poirier, Michael G

“…Nucleosomes restrict the occupancy of most transcription factors (TF) by reducing binding and accelerating dissociation, while a small group of TFs have high…”
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DNA sequence influences hexasome orientation to regulate DNA accessibility by Brehove, Matthew, Shatoff, Elan, Donovan, Benjamin T, Jipa, Caroline M, Bundschuh, Ralf, Poirier, Michael G

“…Nucleosomes, the fundamental organizing units of eukaryotic genomes, contain ∼146 base pairs of DNA wrapped around a histone H3-H4 tetramer and two histone…”
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The nucleosome unwrapping free energy landscape defines distinct regions of transcription factor accessibility and kinetics by Donovan, Benjamin T, Luo, Yi, Meng, Zhiyuan, Poirier, Michael G

“…Transcription factors (TF) require access to target sites within nucleosomes to initiate transcription. The target site position within the nucleosome…”
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Regulating gene expression through control of transcription factor multivalent interactions by Donovan, Benjamin T., Larson, Daniel R.

“…Chong et al. (2022) show how the propensity of transcription factors (TFs) to associate into hubs must be finely regulated for optimal transcription. Chong…”
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Live‐cell imaging reveals the interplay between transcription factors, nucleosomes, and bursting by Donovan, Benjamin T, Huynh, Anh, Ball, David A, Patel, Heta P, Poirier, Michael G, Larson, Daniel R, Ferguson, Matthew L, Lenstra, Tineke L

“…Transcription factors show rapid and reversible binding to chromatin in living cells, and transcription occurs in sporadic bursts, but how these phenomena are…”
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Basic helix-loop-helix pioneer factors interact with the histone octamer to invade nucleosomes and generate nucleosome-depleted regions by Donovan, Benjamin T., Chen, Hengye, Eek, Priit, Meng, Zhiyuan, Jipa, Caroline, Tan, Song, Bai, Lu, Poirier, Michael G.

“…Nucleosomes drastically limit transcription factor (TF) occupancy, while pioneer transcription factors (PFs) somehow circumvent this nucleosome barrier. In…”
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Basic helix-loop-helix pioneer factors interact with the histone octamer to invade nucleosomes and generate nucleosome-depleted regions by Donovan, Benjamin T., Chen, Hengye, Eek, Priit, Meng, Zhiyuan, Jipa, Caroline, Tan, Song, Bai, Lu, Poirier, Michael G.

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Basic helix-loop-helix pioneer factors interact with the histone octamer to invade nucleosomes and generate nucleosome-depleted regions by Donovan, Benjamin T., Chen, Hengye, Eek, Priit, Meng, Zhiyuan, Jipa, Caroline, Tan, Song, Bai, Lu, Poirier, Michael G.

“…Not provided…”
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Yeast Pioneering Transcription Factors Rely on Slowed Dissociation Kinetics to Efficiently Target Nucleosomal Sites by Donovan, Benjamin T., Chen, Hengye, Jipa, Caroline, Yan, Chao, Bai, Lu, Poirier, Michael G.

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Nucleosome Regulation of Transcription Factor Binding Kinetics: Implications for Gene Expression by Donovan, Benjamin T

“…Compaction of genomic DNA into chromatin is an essential regulatory mechanism for eukaryotic gene expression. For example, nucleosomes drastically inhibit…”
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