Search Results - "Donohoe, G."

Neural effects of social environmental stress - an activation likelihood estimation meta-analysis by Mothersill, O, Donohoe, G

“…Social environmental stress, including childhood abuse and deprivation, is associated with increased rates of psychiatric disorders such as schizophrenia and…”
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Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence by Savage, Jeanne E., Jansen, Philip R., Stringer, Sven, Bryois, Julien, Nagel, Mats, Awasthi, Swapnil, Barr, Peter B., Coleman, Jonathan R. I., Grasby, Katrina L., Hammerschlag, Anke R., Kaminski, Jakob A., Karlsson, Robert, Krapohl, Eva, Lam, Max, Nygaard, Marianne, Trampush, Joey W., Young, Hannah, Zabaneh, Delilah, Hägg, Sara, Hansell, Narelle K., Linnarsson, Sten, Montgomery, Grant W., Muñoz-Manchado, Ana B., Quinlan, Erin B., Schumann, Gunter, Webb, Bradley T., White, Tonya, Arking, Dan E., Avramopoulos, Dimitrios, Bilder, Robert M., Bitsios, Panos, Burdick, Katherine E., Cannon, Tyrone D., Christoforou, Andrea, Cirulli, Elizabeth T., Congdon, Eliza, Corvin, Aiden, Davies, Gail, Deary, Ian J., DeRosse, Pamela, Dickinson, Dwight, Djurovic, Srdjan, Donohoe, Gary, Eriksson, Johan G., Espeseth, Thomas, Freimer, Nelson A., Gill, Michael, Glahn, David C., Hariri, Ahmad R., Hatzimanolis, Alex, Keller, Matthew C., Knowles, Emma, Koltai, Deborah, Konte, Bettina, Lahti, Jari, Le Hellard, Stephanie, London, Edythe, Lundervold, Astri J., Malhotra, Anil K., Melle, Ingrid, Morris, Derek, Need, Anna C., Ollier, William, Palotie, Aarno, Payton, Antony, Poldrack, Russell A., Räikkönen, Katri, Reinvang, Ivar, Roussos, Panos, Sabb, Fred W., Scult, Matthew A., Smeland, Olav B., Smyrnis, Nikolaos, Starr, John M., Steen, Vidar M., Stefanis, Nikos C., Straub, Richard E., Sundet, Kjetil, Tiemeier, Henning, Voineskos, Aristotle N., Weinberger, Daniel R., Abecasis, Goncalo, Andreassen, Ole A., Breen, Gerome, Christiansen, Lene, Debrabant, Birgit, Dick, Danielle M., Heinz, Andreas, Hjerling-Leffler, Jens, Kendler, Kenneth S., Medland, Sarah E., Pedersen, Nancy L., Plomin, Robert, Polderman, Tinca J. C., Ripke, Stephan, van der Sluis, Sophie, Sullivan, Patrick F., Vrieze, Scott I., Wright, Margaret J., Posthuma, Danielle

“…Intelligence is highly heritable 1 and a major determinant of human health and well-being 2 . Recent genome-wide meta-analyses have identified 24 genomic loci…”
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Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group by Kelly, S, Jahanshad, N, Zalesky, A, Kochunov, P, Agartz, I, Bouix, S, Bousman, C A, Brouwer, R M, Bruggemann, J, Bustillo, J, Calhoun, V, Carr, V, Catts, S, Chen, X, Chiapponi, C, Cho, Kl K, Corvin, A S, Crespo-Facorro, B, Diaz-Caneja, C M, Dickie, E W, Fatouros-Bergman, H, Flyckt, L, Fouche, J-P, Fukunaga, M, Gollub, R, Guo, H, Gur, R E, Gur, R C, Gurholt, T P, Hashimoto, R, Henskens, F A, Howells, F M, Hulshoff Pol, H E, Isaev, D, Janssen, J, Jönsson, E G, Kikinis, Z, Liu, K, Klauser, P, Kubicki, M, Lagopoulos, J, Langen, C, Lim, K O, Lopez-Jaramillo, C, Lyall, A, Magnotta, V, Mandl, R C W, McCarley, R W, McCarthy-Jones, S, McDonald, C, Melicher, T, Mowry, B, Newell, D T, O'Donnell, P, Oertel-Knöchel, V, Oestreich, L, Paciga, S A, Pantelis, C, Pearlson, G, Pereira, A, Pineda Zapata, J, Piras, F, Potkin, S G, Roiz, R, Roos, A, Rotenberg, D, Satterthwaite, T D, Savadjiev, P, Schall, U, Seal, M L, Seidman, L J, Whelan, C D, Kwon, J S, Spalletta, G, Sprooten, E, Stäblein, M, Stein, D J, Tan, Y, Tan, S, Temmingh, H S, Tønnesen, S, Tordesillas-Gutierrez, D, Doan, N T, Vaidya, J, van Haren, N E M, Vecchio, D, Velakoulis, D, Wang, Z, Wei, D, Weickert, T W, Whalley, H, White, T, Wojcik, J D, Xiang, H, Xie, Z, Yamamori, H, Yang, F, Turner, J, Thompson, P M, Donohoe, G

“…The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly understood, and reported disease effects on the brain vary widely…”
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Brain vs Behavior: An Effect Size Comparison of Neuroimaging and Cognitive Studies of Genetic Risk for Schizophrenia by ROSE, Emma Jane, DONOHOE, Gary

“…Genetic variants associated with increased risk for schizophrenia (SZ) are hypothesized to be more penetrant at the level of brain structure and function than…”
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Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders by Kenny, E M, Cormican, P, Furlong, S, Heron, E, Kenny, G, Fahey, C, Kelleher, E, Ennis, S, Tropea, D, Anney, R, Corvin, A P, Donohoe, G, Gallagher, L, Gill, M, Morris, D W

“…Schizophrenia (SZ) and autism spectrum disorders (ASDs) are complex neurodevelopmental disorders that may share an underlying pathology suggested by shared…”
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Cortisol stress response in psychosis from the high-risk to the chronic stage: a systematic review by Dauvermann, M R, Donohoe, G

“…We review studies of whether cortisol levels following psychosocial stress exposure differ between patients with psychosis and healthy control subjects…”
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Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium by van Erp, T G M, Hibar, D P, Rasmussen, J M, Glahn, D C, Pearlson, G D, Andreassen, O A, Agartz, I, Westlye, L T, Haukvik, U K, Dale, A M, Melle, I, Hartberg, C B, Gruber, O, Kraemer, B, Zilles, D, Donohoe, G, Kelly, S, McDonald, C, Morris, D W, Cannon, D M, Corvin, A, Machielsen, M W J, Koenders, L, de Haan, L, Veltman, D J, Satterthwaite, T D, Wolf, D H, Gur, R C, Gur, R E, Potkin, S G, Mathalon, D H, Mueller, B A, Preda, A, Macciardi, F, Ehrlich, S, Walton, E, Hass, J, Calhoun, V D, Bockholt, H J, Sponheim, S R, Shoemaker, J M, van Haren, N E M, Hulshoff Pol, H E, Ophoff, R A, Kahn, R S, Roiz-Santiañez, R, Crespo-Facorro, B, Wang, L, Alpert, K I, Jönsson, E G, Dimitrova, R, Bois, C, Whalley, H C, McIntosh, A M, Lawrie, S M, Hashimoto, R, Thompson, P M, Turner, J A

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De novo mutations in schizophrenia implicate chromatin remodeling and support a genetic overlap with autism and intellectual disability by McCarthy, S E, Gillis, J, Kramer, M, Lihm, J, Yoon, S, Berstein, Y, Mistry, M, Pavlidis, P, Solomon, R, Ghiban, E, Antoniou, E, Kelleher, E, O'Brien, C, Donohoe, G, Gill, M, Morris, D W, McCombie, W R, Corvin, A

“…Schizophrenia is a serious psychiatric disorder with a broadly undiscovered genetic etiology. Recent studies of de novo mutations (DNMs) in schizophrenia and…”
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GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium by Trampush, J W, Yang, M L Z, Yu, J, Knowles, E, Davies, G, Liewald, D C, Starr, J M, Djurovic, S, Melle, I, Sundet, K, Christoforou, A, Reinvang, I, DeRosse, P, Lundervold, A J, Steen, V M, Espeseth, T, Räikkönen, K, Widen, E, Palotie, A, Eriksson, J G, Giegling, I, Konte, B, Roussos, P, Giakoumaki, S, Burdick, K E, Payton, A, Ollier, W, Horan, M, Chiba-Falek, O, Attix, D K, Need, A C, Cirulli, E T, Voineskos, A N, Stefanis, N C, Avramopoulos, D, Hatzimanolis, A, Arking, D E, Smyrnis, N, Bilder, R M, Freimer, N A, Cannon, T D, London, E, Poldrack, R A, Sabb, F W, Congdon, E, Conley, E D, Scult, M A, Dickinson, D, Straub, R E, Donohoe, G, Morris, D, Corvin, A, Gill, M, Hariri, A R, Weinberger, D R, Pendleton, N, Bitsios, P, Rujescu, D, Lahti, J, Le Hellard, S, Keller, M C, Andreassen, O A, Deary, I J, Glahn, D C, Malhotra, A K, Lencz, T

“…The complex nature of human cognition has resulted in cognitive genomics lagging behind many other fields in terms of gene discovery using genome-wide…”
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Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium by Walton, E, Hibar, D P, van Erp, T G M, Potkin, S G, Roiz-Santiañez, R, Crespo-Facorro, B, Suarez-Pinilla, P, van Haren, N E M, de Zwarte, S M C, Kahn, R S, Cahn, W, Doan, N T, Jørgensen, K N, Gurholt, T P, Agartz, I, Andreassen, O A, Westlye, L T, Melle, I, Berg, A O, Morch-Johnsen, L, Færden, A, Flyckt, L, Fatouros-Bergman, H, Jönsson, E G, Hashimoto, R, Yamamori, H, Fukunaga, M, Jahanshad, N, De Rossi, P, Piras, F, Banaj, N, Spalletta, G, Gur, R E, Gur, R C, Wolf, D H, Satterthwaite, T D, Beard, L M, Sommer, I E, Koops, S, Gruber, O, Richter, A, Krämer, B, Kelly, S, Donohoe, G, McDonald, C, Cannon, D M, Corvin, A, Gill, M, Di Giorgio, A, Bertolino, A, Lawrie, S, Nickson, T, Whalley, H C, Neilson, E, Calhoun, V D, Thompson, P M, Turner, J A, Ehrlich, S

“…Our understanding of the complex relationship between schizophrenia symptomatology and etiological factors can be improved by studying brain-based correlates…”
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Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT) by Lencz, T, Knowles, E, Davies, G, Guha, S, Liewald, D C, Starr, J M, Djurovic, S, Melle, I, Sundet, K, Christoforou, A, Reinvang, I, Mukherjee, S, DeRosse, Pamela, Lundervold, A, Steen, V M, John, M, Espeseth, T, Räikkönen, K, Widen, E, Palotie, A, Eriksson, J G, Giegling, I, Konte, B, Ikeda, M, Roussos, P, Giakoumaki, S, Burdick, K E, Payton, A, Ollier, W, Horan, M, Donohoe, G, Morris, D, Corvin, A, Gill, M, Pendleton, N, Iwata, N, Darvasi, A, Bitsios, P, Rujescu, D, Lahti, J, Hellard, S L, Keller, M C, Andreassen, O A, Deary, I J, Glahn, D C, Malhotra, A K

“…It has long been recognized that generalized deficits in cognitive ability represent a core component of schizophrenia (SCZ), evident before full illness onset…”
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Genetically predicted complement component 4A expression: effects on memory function and middle temporal lobe activation by Donohoe, G, Holland, J, Mothersill, D, McCarthy-Jones, S, Cosgrove, D, Harold, D, Richards, A, Mantripragada, K, Owen, M J, O'Donovan, M C, Gill, M, Corvin, A, Morris, D W

“…The longstanding association between the major histocompatibility complex (MHC) locus and schizophrenia (SZ) risk has recently been accounted for, partially,…”
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Sialic acids: carbohydrate moieties that influence the biological and physical properties of biopharmaceutical proteins and living cells by Byrne, Barry, Donohoe, Gerard G., O’Kennedy, Richard

“…Sialic acids are structurally diverse molecules that have important roles in the physiological reactions and characteristics of prokaryotes and eukaryotes…”
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What have the genomics ever done for the psychoses? by Gill, M, Donohoe, G, Corvin, A

“…Despite the substantial heritability of the psychoses and their genuine public health burden, the applicability of the genomic approach in psychiatry has been…”
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Effectiveness of a low support, remotely accessible, cognitive remediation training programme for chronic psychosis: cognitive, functional and cortical outcomes from a single blind randomised controlled trial by Donohoe, G, Dillon, R, Hargreaves, A, Mothersill, O, Castorina, M, Furey, E, Fagan, A J, Meaney, J F, Fitzmaurice, B, Hallahan, B, McDonald, C, Wykes, T, Corvin, A, Robertson, I H

“…Cognitive remediation (CR) training has emerged as a promising approach to improving cognitive deficits in schizophrenia and related psychosis. The limited…”
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Detecting facial emotion recognition deficits in schizophrenia using dynamic stimuli of varying intensities by Hargreaves, A., Mothersill, O., Anderson, M., Lawless, S., Corvin, A., Donohoe, G.

“…•Dynamic and static stimuli are comparable for emotion recognition in schizophrenia.•Emotion intensity may not be a necessary variable to include in this…”
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Preserved cognitive function is associated with suicidal ideation and single suicide attempts in schizophrenia by Delaney, C, McGrane, J, Cummings, E, Morris, D.W, Tropea, D, Gill, M, Corvin, A, Donohoe, G

“…Abstract Objective Suicide is the leading cause of death in schizophrenia. An association between suicidal behavior and both higher and lower cognitive ability…”
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Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium by Walton, E., Hibar, D. P., Erp, T. G. M., Potkin, S. G., Roiz‐Santiañez, R., Crespo‐Facorro, B., Suarez‐Pinilla, P., Van Haren, N. E. M., Zwarte, S. M. C., Kahn, R. S., Cahn, W., Doan, N. T., Jørgensen, K. N., Gurholt, T. P., Agartz, I., Andreassen, O. A., Westlye, L. T., Melle, I., Berg, A. O., Mørch‐Johnsen, L., Færden, A., Flyckt, L., Fatouros‐Bergman, H., Jönsson, E. G., Hashimoto, R., Yamamori, H., Fukunaga, M., Preda, A., De Rossi, P., Piras, F., Banaj, N., Ciullo, V., Spalletta, G., Gur, R. E., Gur, R. C., Wolf, D. H, Satterthwaite, T. D., Beard, L. M., Sommer, I. E., Koops, S., Gruber, O., Richter, A., Krämer, B., Kelly, S., Donohoe, G., McDonald, C., Cannon, D. M., Corvin, A., Gill, M., Di Giorgio, A., Bertolino, A., Lawrie, S., Nickson, T., Whalley, H. C., Neilson, E., Calhoun, V. D., Thompson, P. M., Turner, J. A., Ehrlich, S., Farde, L., Engberg, G., Erhardt, S., Fatouros‐Bergman, H., Cervenka, S., Schwieler, L., Piehl, F., Ikonen, P., Collste, K., Orhan, F., Malmqvist, A., Hedberg, M.

“…Objective Based on the role of the superior temporal gyrus (STG) in auditory processing, language comprehension and self‐monitoring, this study aimed to…”
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Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility by O'Dushlaine, C, Kenny, E, Heron, E, Donohoe, G, Gill, M, Morris, D, Corvin, A

“…Susceptibility to schizophrenia and bipolar disorder may involve a substantial, shared contribution from thousands of common genetic variants, each of small…”
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Anticholinergic burden in schizophrenia and ability to benefit from psychosocial treatment programmes: a 3-year prospective cohort study by O'Reilly, K, O'Connell, P, Donohoe, G, Coyle, C, O'Sullivan, D, Azvee, Z, Maddock, C, Sharma, K, Sadi, H, McMahon, M, Kennedy, H G

“…Many medications administered to patients with schizophrenia possess anticholinergic properties. When aggregated, pharmacological treatments may result in a…”
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