Search Results - "Donninger, Howard"

Regulatory Role of Immune Cell-Derived Extracellular Vesicles in Cancer: The Message Is in the Envelope by Li, Chi, Donninger, Howard, Eaton, John, Yaddanapudi, Kavitha

“…Extracellular vesicles (EVs) are a heterogenous group of membrane-surrounded structures. Besides serving as a harbor for the unwanted material exocytosed by…”
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RASSF1A tumor suppressor by Donninger, Howard, Vos, Michele D, Clark, Geoffrey J

“…RASSF1A (Ras association domain family 1 isoform A) is a recently discovered tumor suppressor whose inactivation is implicated in the development of many human…”
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RASSF1A Deficiency Enhances RAS-Driven Lung Tumorigenesis by Schmidt, M Lee, Hobbing, Katharine R, Donninger, Howard, Clark, Geoffrey J

“…Mutant K-RAS has been shown to have both tumor-promoting and -suppressing functions, and growing evidence suggests that the RASSF family of tumor suppressors…”
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Cancer Vaccines: Promising Therapeutics or an Unattainable Dream by Donninger, Howard, Li, Chi, Eaton, John W., Yaddanapudi, Kavitha

“…The advent of cancer immunotherapy has revolutionized the field of cancer treatment and offers cancer patients new hope. Although this therapy has proved…”
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A Gene Signature Predictive for Outcome in Advanced Ovarian Cancer Identifies a Survival Factor: Microfibril-Associated Glycoprotein 2 by Mok, Samuel C., Bonome, Tomas, Vathipadiekal, Vinod, Bell, Aaron, Johnson, Michael E., Wong, kwong-kwok, Park, Dong-Choon, Hao, Ke, Yip, Daniel K.P., Donninger, Howard, Ozbun, Laurent, Samimi, Goli, Brady, John, Randonovich, Mike, Pise-Masison, Cindy A., Barrett, J. Carl, Wong, Wing H., Welch, William R., Berkowitz, Ross S., Birrer, Michael J.

“…Advanced stage papillary serous tumors of the ovary are responsible for the majority of ovarian cancer deaths, yet the molecular determinants modulating…”
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Fibroblast-Derived Extracellular Matrices: An Alternative Cell Culture System That Increases Metastatic Cellular Properties by Scherzer, Michael T, Waigel, Sabine, Donninger, Howard, Arumugam, Vennila, Zacharias, Wolfgang, Clark, Geoffrey, Siskind, Leah J, Soucy, Patricia, Beverly, Levi

“…Poor survival rates from lung cancer can largely be attributed to metastatic cells that invade and spread throughout the body. The tumor microenvironment (TME)…”
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Cell Cycle Restriction Is More Important Than Apoptosis Induction for RASSF1A Protein Tumor Suppression by Donninger, Howard, Clark, Jennifer A., Monaghan, Megan K., Schmidt, M. Lee, Vos, Michele, Clark, Geoffrey J.

“…The Ras association domain family protein 1A (RASSF1A) is arguably one of the most frequently inactivated tumor suppressors in human cancer. RASSF1A modulates…”
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p21-activated kinase 3 (PAK3) is an AP-1 regulated gene contributing to actin organisation and migration of transformed fibroblasts by Holderness Parker, Nina, Donninger, Howard, Birrer, Michael J, Leaner, Virna D

“…Activating Protein 1 (AP-1) plays a vital role in cell proliferation, differentiation and apoptosis. While de-regulation of AP-1 has been linked to many…”
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The RASSF1A Tumor Suppressor Activates Bax via MOAP-1 by Vos, Michele D., Dallol, Ashraf, Eckfeld, Kristin, Allen, Nadia P.C., Donninger, Howard, Hesson, Luke B., Calvisi, Diego, Latif, Farida, Clark, Geoffrey J.

“…The novel tumor suppressor RASSF1A is frequently inactivated during human tumorigenesis by promoter methylation. RASSF1A may serve as a node in the integration…”
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Cell fate determination factor DACH1 inhibits c-Jun-induced contact-independent growth by Wu, Kongming, Liu, Manran, Li, Anping, Donninger, Howard, Rao, Mahadev, Jiao, Xuanmao, Lisanti, Michael P, Cvekl, Ales, Birrer, Michael, Pestell, Richard G

“…The cell fate determination factor DACH1 plays a key role in cellular differentiation in metazoans. DACH1 is engaged in multiple context-dependent complexes…”
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Proteomics Analysis Reveals Novel RASSF2 Interaction Partners by Barnoud, Thibaut, Wilkey, Daniel W, Merchant, Michael L, Clark, Jennifer A, Donninger, Howard

“…RASSF2 is a tumor suppressor that shares homology with other Ras-association domain (RASSF) family members. It is a powerful pro-apoptotic K-Ras effector that…”
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The Ras Effector RASSF2 Controls the PAR-4 Tumor Suppressor by Donninger, Howard, Hesson, Luke, Vos, Michele, Beebe, Kristin, Gordon, Laura, Sidransky, David, Liu, Jun Wei, Schlegel, Thomas, Payne, Shannon, Hartmann, Arndt, Latif, Farida, Clark, Geoffrey J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Cyclin A Is a c-Jun Target Gene and Is Necessary for c-Jun-induced Anchorage-independent Growth in RAT1a Cells by Katabami, Motoo, Donninger, Howard, Hommura, Fumihiro, Leaner, Virna D., Kinoshita, Ichiro, Chick, Jeffrey F.B., Birrer, Michael J.

“…Overexpression of c-Jun enables Rat1a cells to grow in an anchorage-independent manner. We used an inducible c-Jun system under the regulation of doxycycline…”
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Rhinovirus infects primary human airway fibroblasts and induces a neutrophil chemokine and a permeability factor by Ghildyal, Reena, Dagher, Hayat, Donninger, Howard, de Silva, Dinesha, Li, Xun, Freezer, Nicholas J., Wilson, John W., Bardin, Philip G.

“…The events linking rhinovirus (RV) infection to airway symptoms are poorly understood. The virus initially infects airway epithelium followed by a vigorous…”
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Rhinovirus Induction of the CXC Chemokine Epithelial-Neutrophil Activating Peptide-78 in Bronchial Epithelium by Donninger, Howard, Glashoff, Richard, Haitchi, Hans-Michael, Syce, James A., Ghildyal, Reena, van Rensburg, Estrelita, Bardin, Philip G.

“…Epithelial-neutrophil activating peptide-78 (ENA-78) induces neutrophil migration, an early response to viral infection. Rhinovirus serotype 16 (RV16) was used…”
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Loss of RASSF2 Enhances Tumorigencity of Lung Cancer Cells and Confers Resistance to Chemotherapy by Clark, Jennifer, Freeman, Jessica, Donninger, Howard

“…RASSF2 is a novel pro-apoptotic effector of K-Ras that is frequently inactivated in a variety of primary tumors by promoter methylation. Inactivation of RASSF2…”
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NORE1A tumor suppressor candidate modulates p21CIP1 via p53 by Calvisi, Diego F, Donninger, Howard, Vos, Michele D, Birrer, Michael J, Gordon, Laura, Leaner, Virna, Clark, Geoffrey J

“…NORE1A (RASSF5) is a proapoptotic Ras effector that is frequently inactivated by promoter methylation in human tumors. It is structurally related to the…”
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p75-Ras-GRF1 Is a c-Jun/AP-1 Target Protein: Its Up Regulation Results in Increased Ras Activity and Is Necessary for c-Jun-Induced Nonadherent Growth of Rat1a Cells by Leaner, Virna D., Donninger, Howard, Ellis, Chad A., Clark, Geoffrey J., Birrer, Michael J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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HMG-I/Y Is a c-Jun/Activator Protein-1 Target Gene and Is Necessary for c-Jun–Induced Anchorage-Independent Growth in Rat1a Cells by Hommura, Fumihiro, Katabami, Motoo, Leaner, Virna D, Donninger, Howard, Sumter, Takita F, Resar, Linda M S, Birrer, Michael J

“…The transcription complex activator protein-1 (AP-1) plays a role in a diverse number of cellular processes including proliferation, differentiation, and…”
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RASSF1A and the Taxol Response in Ovarian Cancer by Clark, Geoffrey J., Birrer, Michael J., Donninger, Howard, Kassler, Susannah

“…The RASSF1A tumor suppressor gene is frequently inactivated by promoter methylation in human tumors. The RASSF1A protein forms an endogenous complex with…”
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