Search Results - "Donners, Marjo M"

Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo by Jetten, Nadine, Verbruggen, Sanne, Gijbels, Marion J., Post, Mark J., De Winther, Menno P. J., Donners, Marjo M. P. C.

“…Objective Macrophages show extreme heterogeneity and different subsets have been characterized by their activation route and their function. For instance,…”
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ADAM10 and ADAM17, Major Regulators of Chronic Kidney Disease Induced Atherosclerosis? by Maas, Sanne L, Donners, Marjo M P C, van der Vorst, Emiel P C

“…Chronic kidney disease (CKD) is a major health problem, affecting millions of people worldwide, in particular hypertensive and diabetic patients. CKD patients…”
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Hematopoietic miR155 deficiency enhances atherosclerosis and decreases plaque stability in hyperlipidemic mice by Donners, Marjo M P C, Wolfs, Ine M J, Stöger, Lauran J, van der Vorst, Emiel P C, Pöttgens, Chantal C H, Heymans, Stephane, Schroen, Blanche, Gijbels, Marion J J, de Winther, Menno P J

“…microRNA-155 (miR155) is a central regulator of immune responses that is induced by inflammatory mediators. Although miR155 is considered to be a…”
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Bone marrow‐specific caspase‐1/11 deficiency inhibits atherosclerosis development in Ldlr−/− mice by Hendrikx, Tim, Jeurissen, Mike L. J, Gorp, Patrick J, Gijbels, Marion J, Walenbergh, Sofie M. A, Houben, Tom, Gorp, Rick, Pöttgens, Chantal C, Stienstra, Rinke, Netea, Mihai G, Hofker, Marten H, Donners, Marjo M. P. C, Shiri‐Sverdlov, Ronit

“…Recent investigations have suggested that inflammasome activation plays an important role during atherosclerosis. Upon activation, the inflammasome induces…”
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Genome-scale metabolic network of human carotid plaque reveals the pivotal role of glutamine/glutamate metabolism in macrophage modulating plaque inflammation and vulnerability by Jin, Han, Zhang, Cheng, Nagenborg, Jan, Juhasz, Peter, Ruder, Adele V, Sikkink, Cornelis J J M, Mees, Barend M E, Waring, Olivia, Sluimer, Judith C, Neumann, Dietbert, Goossens, Pieter, Donners, Marjo M P C, Mardinoglu, Adil, Biessen, Erik A L

“…Metabolism is increasingly recognized as a key regulator of the function and phenotype of the primary cellular constituents of the atherosclerotic vascular…”
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Local delivery of polarized macrophages improves reperfusion recovery in a mouse hind limb ischemia model by Jetten, Nadine, Donners, Marjo M P C, Wagenaar, Allard, Cleutjens, Jack P M, van Rooijen, Nico, de Winther, Menno P J, Post, Mark J

“…Enhancement of collateral development in coronary or peripheral artery disease is a therapeutic target, but it has proven difficult to achieve. Macrophages are…”
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A disintegrin and metalloproteases: Molecular scissors in angiogenesis, inflammation and atherosclerosis by van der Vorst, Emiel P.C, Keijbeck, Anke A, de Winther, Menno P.J, Donners, Marjo M.P.C

“…Abstract A Disintegrin And Metalloproteases (ADAMs) are enzymes that cleave (shed) the extracellular domains of various cell surface molecules, e.g. adhesion…”
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Cathepsin K Deficiency Prevents the Aggravated Vascular Remodeling Response to Flow Cessation in ApoE-/- Mice by Donners, Marjo M P C, Bai, Lili, Lutgens, Suzanne P M, Wijnands, Erwin, Johnson, Jason, Schurgers, Leon J, Liu, Cong-Lin, Daemen, Mat J A P, Cleutjens, Kitty B J M, Shi, Guo-Ping, Biessen, Erik A L, Heeneman, Sylvia

“…Cathepsin K (catK) is a potent lysosomal cysteine protease involved in extracellular matrix (ECM) degradation and inflammatory remodeling responses. Here we…”
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GM-CSF-activated STAT5A regulates macrophage functions and inflammation in atherosclerosis by Nagenborg, Jan, Jin, Han, Ruder, Adele V., Temmerman, Lieve, Mees, Barend, Schalkwijk, Casper, Müller-Klieser, Daniel, Berg, Thorsten, Goossens, Pieter, Donners, Marjo M. P. C., Biessen, Erik A. L.

“…IntroductionInhibition of STAT5 was recently reported to reduce murine atherosclerosis. However, the role of STAT5 isoforms, and more in particular STAT5A in…”
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Reprogramming macrophages to an anti‐inflammatory phenotype by helminth antigens reduces murine atherosclerosis by Wolfs, Ine M. J., Stöger, J. Lauran, Goossens, Pieter, Pöttgens, Chantal, Gijbels, Marion J. J., Wijnands, Erwin, Vorst, Emiel P. C., Gorp, Patrick, Beckers, Linda, Engel, David, Biessen, Erik A. L., Kraal, Georg, Die, Irma, Donners, Marjo M. P. C., Winther, Menno P. J.

“…Atherosclerosis is a lipid‐driven inflammatory disease of the vessel wall, characterized by the chronic activation of macrophages. We investigated whether the…”
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Shedding of Klotho: Functional Implications in Chronic Kidney Disease and Associated Vascular Disease by Saar-Kovrov, Valeria, Donners, Marjo M P C, van der Vorst, Emiel P C

“…α-Klotho (Klotho) exists in two different forms, a membrane-bound and soluble form, which are highly expressed in the kidney. Both forms play an important role…”
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Identification of a gene network driving the attenuated response to lipopolysaccharide of monocytes from hypertensive coronary artery disease patients by Lu, Chang, Donners, Marjo M P C, de Baaij, Julius B J, Jin, Han, Otten, Jeroen J T, Manca, Marco, van Zonneveld, Anton Jan, Jukema, J Wouter, Kraaijeveld, Adriaan, Kuiper, Johan, Pasterkamp, Gerard, Mees, Barend, Sluimer, Judith C, Cavill, Rachel, Karel, Joël M H, Goossens, Pieter, Biessen, Erik A L

“…The impact of cardiovascular disease (CVD) risk factors, encompassing various biological determinants and unhealthy lifestyles, on the functional dynamics of…”
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Whole body and hematopoietic ADAM8 deficiency does not influence advanced atherosclerotic lesion development, despite its association with human plaque progression by Theodorou, Kosta, van der Vorst, Emiel P. C., Gijbels, Marion J., Wolfs, Ine M. J., Jeurissen, Mike, Theelen, Thomas L., Sluimer, Judith C., Wijnands, Erwin, Cleutjens, Jack P., Li, Yu, Jansen, Yvonne, Weber, Christian, Ludwig, Andreas, Bentzon, Jacob F., Bartsch, Jörg W., Biessen, Erik A. L., Donners, Marjo M. P. C.

“…Although A Disintegrin And Metalloproteinase 8 (ADAM8) is not crucial for tissue development and homeostasis, it has been implicated in various inflammatory…”
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ADAM10-Mediated Cleavage of ICAM-1 Is Involved in Neutrophil Transendothelial Migration by Morsing, Sofia K H, Rademakers, Timo, Brouns, Sanne L N, Stalborch, Anne-Marieke D van, Donners, Marjo M P C, van Buul, Jaap D

“…To efficiently cross the endothelial barrier during inflammation, neutrophils first firmly adhere to the endothelial surface using the endothelial adhesion…”
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Two-faced Janus: the dual role of macrophages in atherosclerotic calcification by Waring, Olivia J, Skenteris, Nikolaos T, Biessen, Erik A L, Donners, Marjo M P C

“…Calcification is an independent predictor of atherosclerosis-related cardiovascular events. Microcalcification is linked to inflamed, unstable lesions, in…”
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The CD40-TRAF6 axis is the key regulator of the CD40/CD40L system in neointima formation and arterial remodeling by Donners, Marjo M.P.C., Beckers, Linda, Lievens, Dirk, Munnix, Imke, Heemskerk, Johan, Janssen, Ben J., Wijnands, Erwin, Cleutjens, Jack, Zernecke, Alma, Weber, Christian, Ahonen, Cory L., Benbow, Ulrike, Newby, Andrew C., Noelle, Randolph J., Daemen, Mat J.A.P., Lutgens, Esther

“…We investigated the role of CD40 and CD40L in neointima formation and identified the downstream CD40-signaling intermediates (tumor necrosis factor…”
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Endothelial ADAM10 controls cellular response to oxLDL and its deficiency exacerbates atherosclerosis with intraplaque hemorrhage and neovascularization in mice by van der Vorst, Emiel P C, Maas, Sanne L, Theodorou, Kosta, Peters, Linsey J F, Jin, Han, Rademakers, Timo, Gijbels, Marion J, Rousch, Mat, Jansen, Yvonne, Weber, Christian, Lehrke, Michael, Lebherz, Corinna, Yildiz, Daniela, Ludwig, Andreas, Bentzon, Jacob F, Biessen, Erik A L, Donners, Marjo M P C

“…The transmembrane protease A Disintegrin And Metalloproteinase 10 (ADAM10) displays a "pattern regulatory function," by cleaving a range of membrane-bound…”
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Message in a Microbottle: Modulation of Vascular Inflammation and Atherosclerosis by Extracellular Vesicles by van der Vorst, Emiel P C, de Jong, Renske J, Donners, Marjo M P C

“…Extracellular vesicles (EVs) have emerged as a novel intercellular communication system. By carrying bioactive lipids, miRNAs and proteins they can modulate…”
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Heterogeneity of atherosclerotic plaque macrophage origin, phenotype and functions: Implications for treatment by Nagenborg, Jan, Goossens, Pieter, Biessen, Erik A.L., Donners, Marjo M.P.C.

“…Macrophages are key players in atherosclerotic lesions, regulating the local inflammatory milieu and plaque stability by the secretion of many inflammatory…”
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Integrating multiplex immunofluorescent and mass spectrometry imaging to map myeloid heterogeneity in its metabolic and cellular context by Goossens, Pieter, Lu, Chang, Cao, Jianhua, Gijbels, Marion J., Karel, Joël M.H., Wijnands, Erwin, Claes, Britt S.R., Fazzi, Gregorio E., Hendriks, Tim F.E., Wouters, Kristiaan, Smirnov, Evgueni, van Zandvoort, Marc J.M., Balluff, Benjamin, Cuypers, Eva, Donners, Marjo M.P.C., Heeren, Ron M.A., Biessen, Erik A.L.

“…Cells often adopt different phenotypes, dictated by tissue-specific or local signals such as cell-cell and cell-matrix contacts or molecular micro-environment…”
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