Search Results - "Donner, M E"

Acute and subchronic oral toxicity studies in rats with nanoscale and pigment grade titanium dioxide particles by Warheit, D.B., Brown, S.C., Donner, E.M.

“…Data generated using standardized testing protocols for toxicity studies generally provide reproducible and reliable results for establishing safe levels and…”
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In vivo micronucleus studies with 6 titanium dioxide materials (3 pigment-grade & 3 nanoscale) in orally-exposed rats by Donner, E.M., Myhre, A., Brown, S.C., Boatman, R., Warheit, D.B.

“…Six pigment-grade (pg) or ultrafine (uf)/nanoscale (anatase and/or rutile) titanium dioxide (TiO2) particulates were evaluated for in vivo genotoxicity (OECD…”
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Estrogen treatment enhances hereditary renal tumor development in Eker rats by WOLF, D. C, GOLDSWORTHY, T. L, DONNER, E. M, HARDEN, R, FITZPATRICK, B, EVERITT, J. I

“…Hormonal influences are known to affect the development of renal cell carcinoma in man and laboratory animal models. We tested the hypothesis that estrogen…”
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Can mutagenicity information be useful in an Integrated Testing Strategy (ITS) for skin sensitization? by Patlewicz, G., Mekenyan, O., Dimitrova, G., Kuseva, C., Todorov, M., Kotov, S., Stoeva, S., Donner, E.M.

“…Our previous work has investigated the utility of mutagenicity data in the development and application of Integrated Testing Strategies (ITS) for skin…”
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Promotion by sodium barbital induces early development but does not increase the multiplicity of hereditary renal tumors in Eker rats by Wolf, D.C., Goldsworthy, T.L., Janszen, D.B., Harden, R., Donner, E.M., David, C.S., Everitt, J.I.

“…Induced cell proliferation is important in the mode of action of many non-genotoxic renal carcinogens. Since Tsc2 mutant (Eker) rats are genetically…”
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Evaluation of Effects from Repeated Inhalation Exposure of F344 Rats to High Concentrations of Propylene by Pottenger, Lynn H., Malley, Linda A., Bogdanffy, Matthew S., Donner, E. Maria, Upton, Patricia B., Li, Yutai, Walker, Vernon E., Harkema, Jack R., Banton, Marcy I., Swenberg, James A.

“…Chronic exposure to propylene does not result in any increased incidence of tumors, yet does increase N7-hydroxypropylguanine (N7-HPGua) adducts in tissue DNA…”
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A genetic hypothesis for cause of death during the 1952 london fog by Mage, D.T., Donner, E.M.

“…Analysis of autopsied cause of death during the London Fog of 1952 indicates that mortality from all respiratory causes, sudden and delayed, had a consistent…”
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Developmental Regulation of Constitutive and Inducible Expression of Hepatocyte-Specific Genes in the Mouse by Donner, Maria E., Leonard, Claire M., Gluecksohn-Waelsch, Salome

“…Deletions in chromosome 7 of the mouse have been shown to cause failure of expression of certain liver-specific enzymes in newborn deletion homozygotes. Among…”
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The locus encoding αA-crystallin is closely linked to H-2K on mouse chromosome 17 by SKOW, L. C, DONNER, M. E

“…We have used a complementary DNA (cDNA) for mouse alpha A-crystallin to probe genomic DNA for restriction fragment length polymorphisms which could be used to…”
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The fifty percent male excess of infant respiratory mortality by Mage, DT, Donner, EM

“…Aim: To test whether infant mortality from clearly respiratory causes has a consistent male excess that is different from the male excess in most cardiac…”
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The relationship between p53 status, DNA repair and chromatid aberration induction in G2 mouse embryo fibroblast cells treated with bleomycin by Donner, E.Maria, Preston, R.Julian

“…The involvement of p53 in the formation of chromosome aberrations was assessed by analyzing bleomycin-induced, chromatid-type aberrations in G2 phase…”
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In vitro genotoxicity testing of (1-chloroethenyl)oxirane, a metabolite of β-chloroprene by Himmelstein, Matthew W, Lawrence Gladnick, N, Maria Donner, E, Snyder, Ronald D, Valentine, Rudolph

“…(1-Chloroethenyl)oxirane (CEO) is a metabolite of β-chloroprene (2-chloro-1,3-butadiene, CD). The purpose of this study was to evaluate the in vitro mutagenic…”
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A comparison of the roles of p53 mutation and AraC inhibition in the enhancement of bleomycin-induced chromatid aberrations in mouse and human cells by Allio, T, Donner, E M, Preston, R J

“…Previous studies have shown that p53 is involved in the repair of bleomycin-induced DNA damage, and that the frequency of bleomycin-induced chromatid…”
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Mapping of mouse gamma crystallin genes on chromosome 1 by SKOW, L. C, DONNER, M. E, SHU-MEI HUANG, GARDNER, J. M, TAYLOR, B. A, BEAMER, W. G, LALLEY, P. A

“…Restriction fragments analysis of DNA from mouse-hamster somatic-cell hybrid clones revealed that a mouse gamma crystallin cDNA hybridized to genomic sequences…”
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Rationale of genotoxieity testing of nanomaterials: Regulatory requirements and appropriateness of available OECD test guidelines by Warheit, D B, Donner, E M

“…The development of an environmental health and safety risk management system for nanoscale particle-types requires a base set of hazard data. Accurate…”
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A second polymorphic lens crystallin (LEN-2) in the mouse: genetic and biochemical analysis of LEN-1 and LEN-2 by Skow, L.C, Donner, M.E, Popp, R.A, Bailiff, E.G

“…Two electrophoretic polymorphisms affecting lens crystallins, designated LEN-1 and LEN-2, have been discovered among inbred strains of mice. Analysis by…”
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Toxicological evaluation of sodium perfluorohexanoate by Loveless, Scott E, Slezak, Brian, Serex, Tessa, Lewis, Joseph, Mukerji, Pushkor, O’Connor, John C, Donner, E. Maria, Frame, Steven R, Korzeniowski, Stephen H, Buck, Robert C

“…Abstract Sodium perfluorohexanoate [NaPFHx, F(CF2 )5 CO2 Na, CAS#2923-26-4] was evaluated in acute, 90-day subchronic, one-generation reproduction,…”
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Four Week Feeding Toxicity Study with Phenylphosphinic Acid in Rats by Maria Donner, E., Kennedy, Gerald L., Stadler, Judith S.

“…Abstract Phenylphosphinic acid was fed in graded concentrations of either 0 (control), 100, 1,000, or 10,000 ppm to rats for 28 days. These concentrations…”
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Reciprocal translocations in somatic and germ cells of mice chronically exposed by inhalation to ethylene oxide: implications for risk assessment by Donner, E. Maria, Wong, Brian A., James, R. Arden, Preston, R. Julian

“…Groups of male B6C3F1 mice were exposed by inhalation to 0, 25, 50, 100 or 200 p.p.m. ethylene oxide (EO) for up to 48 weeks (6 hours/day, 5 days/week)…”
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Development of a base set of toxicity tests using ultrafine TiO sub(2) particles as a component of nanoparticle risk management by Warheit, D B, Hoke, R A, Finlay, C, Donner, E M, Reed, K L, Sayes, C M

“…The development of a risk management system for nanoscale or ultrafine particle-types requires a base set of hazard data. Assessing risk is a function of…”
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