Search Results - "Donner, B"

Global Extent of Early Eocene Hyperthermal Events: A New Pacific Benthic Foraminiferal Isotope Record From Shatsky Rise (ODP Site 1209) by Westerhold, T., Röhl, U., Donner, B., Zachos, J. C.

“…Studying the dynamics of past global warming events during the late Paleocene to middle Eocene informs our understanding of Earth's carbon cycle behavior under…”
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A Phosphatidylinositol 3-Kinase/Akt Pathway Promotes Translocation of Mdm2 from the Cytoplasm to the Nucleus by Mayo, Lindsey D., Donner, David B.

“…The Mdm2 oncoprotein promotes cell survival and cell cycle progression by inhibiting the p53 tumor suppressor protein. To regulate p53, Mdm2 must gain nuclear…”
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The PTEN, Mdm2, p53 tumor suppressor–oncoprotein network by Mayo, Lindsey D, Donner, David B

“…Oncoproteins and tumor-suppressor proteins regulate cell growth and viability. Recent observations show that phosphoinositide 3-kinase (PtdIns 3-kinase)–Akt…”
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Determinants of Planktonic Foraminifera Calcite Flux: Implications for the Prediction of Intra‐ and Inter‐Annual Pelagic Carbonate Budgets by Kiss, P., Jonkers, L., Hudáčková, N., Reuter, R. T., Donner, B., Fischer, G., Kucera, M.

“…Planktonic foraminifera precipitate calcite shells, which after the death of the organisms are exported to the seafloor. Globally, the resulting calcite flux…”
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Metastatic colorectal adenocarcinoma tumor purity assessment from whole exome sequencing data by Tbeileh, Noura, Timmerman, Luika, Mattis, Aras N, Toriguchi, Kan, Kasai, Yosuke, Corvera, Carlos, Nakakura, Eric, Hirose, Kenzo, Donner, David B, Warren, Robert S, Karelehto, Eveliina

“…Tumors rich in stroma are associated with advanced stage and poor prognosis in colorectal adenocarcinoma (CRC). Abundance of stromal cells also has…”
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Changes in the Dust‐Influenced Biological Carbon Pump in the Canary Current System: Implications From a Coastal and an Offshore Sediment Trap Record Off Cape Blanc, Mauritania by Fischer, G., Romero, O., Toby, E., Iversen, M., Donner, B., Mollenhauer, G., Nowald, N., Ruhland, G., Klann, M., Hamady, B., Wefer, G.

“…Long‐term data characterizing the oceans' biological carbon pump are essential for understanding impacts of climate variability on marine ecosystems. The…”
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NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase by Nidai Ozes, Osman, Mayo, Lindsey D, Gustin, Jason A, Pfeffer, Susan R, Pfeffer, Lawrence M, Donner, David B

“…Activation of the nuclear transcription factor NF-κB by inflammatory cytokines requires the successive action of NF-κB-inducing kinase (NIK) and an IκB-kinase…”
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PTEN Protects p53 from Mdm2 and Sensitizes Cancer Cells to Chemotherapy by Mayo, Lindsey D, Dixon, Jack E, Durden, Donald L, Tonks, Nickolas K, Donner, David B

“…The PTEN tumor suppressor protein inhibits phosphatidylinositol 3-kinase (PI3K)/Akt signaling that promotes translocation of Mdm2 into the nucleus. When…”
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Expression of human papillomavirus type 16 E6 and E7 oncoproteins in primary foreskin keratinocytes is sufficient to alter the expression of angiogenic factors by TOUSSAINT-SMITH, Esra, DONNER, David B, ROMAN, Ann

“…Human papillomavirus (HPV) 16 is involved in causing cervical cancer. The E6 and E7 proteins of HPV 16 immortalize human keratinocytes and this is due, at…”
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High thymidylate synthase gene expression predicts poor outcome after resection of hepatocellular carcinoma by Donner, David B, Nakakura, Eric K, Venook, Alan P, Lenz, Heinz-Josef, Zhang, Wu, Hwang, Jimee, Bergsland, Emily K, Lin, Meng Hsun, Toriguchi, Kan, Antonia, Ricardo J, Warren, Robert S

“…Prognosis after resection of hepatocellular carcinoma (HCC) is highly variable. Compared to clinicopathologic factors, the use of molecular markers to predict…”
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CYP3A4 Mediates Growth of Estrogen Receptor-positive Breast Cancer Cells in Part by Inducing Nuclear Translocation of Phospho-Stat3 through Biosynthesis of (±)-14,15-Epoxyeicosatrienoic Acid (EET) by Mitra, Ranjana, Guo, Zhijun, Milani, Monica, Mesaros, Clementina, Rodriguez, Mariangellys, Nguyen, Julia, Luo, Xianghua, Clarke, Duncan, Lamba, Jatinder, Schuetz, Erin, Donner, David B., Puli, Narender, Falck, John R., Capdevila, Jorge, Gupta, Kalpna, Blair, Ian A., Potter, David A.

“…CYP3A4 expression in breast cancer correlates with decreased overall survival, but the mechanisms are unknown. Cytochrome P450 gene profiling by RNAi silencing…”
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Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors by Ducker, G S, Atreya, C E, Simko, J P, Hom, Y K, Matli, M R, Benes, C H, Hann, B, Nakakura, E K, Bergsland, E K, Donner, D B, Settleman, J, Shokat, K M, Warren, R S

“…The mammalian target of rapamycin (mTOR) regulates cell growth by integrating nutrient and growth factor signaling and is strongly implicated in cancer. But…”
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A Phosphatidylinositol 3-Kinase/Akt/mTOR Pathway Mediates and PTEN Antagonizes Tumor Necrosis Factor Inhibition of Insulin Signaling through Insulin Receptor Substrate-1 by Ozes, Osman Nidai, Akca, Hakan, Mayo, Lindsey D., Gustin, Jason A., Maehama, Tomohiko, Dixon, Jack E., Donner, David B.

“…Tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) by the insulin receptor permits this docking protein to interact with signaling proteins that…”
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Phosphorylation of Human p53 at Serine 46 Determines Promoter Selection and whether Apoptosis Is Attenuated or Amplified by Mayo, Lindsey D., Seo, Young Rok, Jackson, Mark W., Smith, Martin L., Guzman, Javier Rivera, Korgaonkar, Chandrashekhar K., Donner, David B.

“…The capacity of DNA damaging agents to induce apoptosis is regulated by target gene induction by p53. We found that p53 targeted MDM2 in cells in which DNA…”
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The hsp90-related Protein TRAP1 Is a Mitochondrial Protein with Distinct Functional Properties by Felts, Sara J., Owen, Barbara A.L., Nguyen, PhuongMai, Trepel, Jane, Donner, David B., Toft, David O.

“…The hsp90 family of molecular chaperones was expanded recently due to the cloning of TRAP1 and hsp75 by yeast two-hybrid screens. Careful analysis of the human…”
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Autocrine activation of PDGFRα promotes the progression of ovarian cancer by MATEI, D, EMERSON, R. E, LAI, Y.-C, BALDRIDGE, L. A, RAO, J, YIANNOUTSOS, C, DONNER, D. B

“…Platelet-derived growth factor receptor (PDGFR)α expression was found in ovarian cancer cells and tumors by microarray hybridization. This led us to test…”
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Autophagy: A new target for advanced papillary thyroid cancer therapy by Lin, Chi-Iou, PhD, Whang, Edward E., MD, Abramson, Michael A., MD, Jiang, Xiaofeng, PhD, Price, Brendan D., PhD, Donner, David B., PhD, Moore, Francis D., MD, Ruan, Daniel T., MD

“…Background Autophagy is a conserved response to stress that facilitates cell survival in some contexts and promotes cell death in others. We sought to…”
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Pelagic–benthic coupling within an upwelling system of the subtropical northeast Atlantic over the last 35 ka BP by McKay, C.L., Filipsson, H.L., Romero, O.E., Stuut, J.-B.W., Donner, B.

“…We present a high resolution, multiproxy study of the relationship between pelagic and benthic environments of a coastal upwelling system in the subtropical NE…”
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Galectin-3 Targeted Therapy with a Small Molecule Inhibitor Activates Apoptosis and Enhances Both Chemosensitivity and Radiosensitivity in Papillary Thyroid Cancer by Lin, Chi-Iou, Whang, Edward E, Donner, David B, Jiang, Xiaofeng, Price, Brendan D, Carothers, Adelaide M, Delaine, Tamara, Leffler, Hakon, Nilsson, Ulf J, Nose, Vania, Moore, Jr, Francis D, Ruan, Daniel T

“…Although most patients with papillary thyroid cancer (PTC) have favorable outcomes, some have advanced PTC that is refractory to external beam radiation and…”
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Mitogen Inducible Gene-6 Is a Prognostic Marker for Patients with Colorectal Liver Metastases by Donner, David B., Ruan, Dan T., Toriguchi, Kan, Bergsland, Emily K., Nakakura, Eric K., Lin, Meng Hsun, Antonia, Ricardo J., Warren, Robert S.

“…PURPOSE: Prognostic schemes that rely on clinical variables to predict outcome after resection of colorectal metastases remain imperfect. We hypothesized that…”
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