Search Results - "Donnelly, Ryan F."

Implantable Polymeric Drug Delivery Devices: Classification, Manufacture, Materials, and Clinical Applications by Stewart, Sarah A, Domínguez-Robles, Juan, Donnelly, Ryan F, Larrañeta, Eneko

“…The oral route is a popular and convenient means of drug delivery. However, despite its advantages, it also has challenges. Many drugs are not suitable for…”
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Hollow microneedles: A perspective in biomedical applications by Cárcamo-Martínez, Álvaro, Mallon, Brónach, Domínguez-Robles, Juan, Vora, Lalitkumar K., Anjani, Qonita K., Donnelly, Ryan F.

“…[Display omitted] Microneedles (MN) have the potential to become a highly progressive device for both drug delivery and monitoring purposes as they penetrate…”
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Pullulan-based dissolving microneedle arrays for enhanced transdermal delivery of small and large biomolecules by Vora, Lalitkumar K., Courtenay, Aaron J., Tekko, Ismaiel A., Larrañeta, Eneko, Donnelly, Ryan F.

“…One specific technological advance in transdermal drug delivery is the development of dissolving microneedles (DMNs), which efficiently deliver therapeutics…”
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Bacterially sensitive nanoparticle-based dissolving microneedles of doxycycline for enhanced treatment of bacterial biofilm skin infection: A proof of concept study by Permana, Andi Dian, Mir, Maria, Utomo, Emilia, Donnelly, Ryan F.

“…The presence of bacterial biofilms in wounds is a main issue in the healing process. Conventional therapy of bacterial biofilms is hampered by the poor…”
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Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the stratum corneum by Alkilani, Ahlam Zaid, McCrudden, Maelíosa T C, Donnelly, Ryan F

“…The skin offers an accessible and convenient site for the administration of medications. To this end, the field of transdermal drug delivery, aimed at…”
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Thermosensitive and mucoadhesive in situ ocular gel for effective local delivery and antifungal activity of itraconazole nanocrystal in the treatment of fungal keratitis by Permana, Andi Dian, Utami, Rifka Nurul, Layadi, Patricia, Himawan, Achmad, Juniarti, Nana, Anjani, Qonita Kurnia, Utomo, Emilia, Mardikasari, Sandra Aulia, Arjuna, Andi, Donnelly, Ryan F.

“…[Display omitted] Itraconazole is a lipophilic drug, which limits its absorption for ocular administration. This study focused on the incorporation of…”
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Hydrogel-Forming Microneedle Arrays for Enhanced Transdermal Drug Delivery by Donnelly, Ryan F., Singh, Thakur Raghu Raj, Garland, Martin J., Migalska, Katarzyna, Majithiya, Rita, McCrudden, Cian M., Kole, Prashant Laxman, Mahmood, Tuan Mazlelaa Tuan, McCarthy, Helen O., Woolfson, A. David

“…Unique microneedle arrays prepared from crosslinked polymers, which contain no drug themselves, are described. They rapidly take up skin interstitial fluid…”
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Microneedle-Based Delivery: An Overview of Current Applications and Trends by Guillot, Antonio José, Cordeiro, Ana Sara, Donnelly, Ryan F., Montesinos, M. Carmen, Garrigues, Teresa M., Melero, Ana

“…Microneedle arrays (MNA) are considered as one of the most promising resources to achieve systemic effects by transdermal delivery of drugs. They are designed…”
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Hydrogels for Hydrophobic Drug Delivery. Classification, Synthesis and Applications by Larrañeta, Eneko, Stewart, Sarah, Ervine, Michael, Al-Kasasbeh, Rehan, Donnelly, Ryan F

“…Hydrogels have been shown to be very useful in the field of drug delivery due to their high biocompatibility and ability to sustain delivery. Therefore, the…”
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Beneath the Skin: A Review of Current Trends and Future Prospects of Transdermal Drug Delivery Systems by Alkilani, Ahlam Zaid, Nasereddin, Jehad, Hamed, Rania, Nimrawi, Sukaina, Hussein, Ghaid, Abo-Zour, Hadeel, Donnelly, Ryan F

“…The ideal drug delivery system has a bioavailability comparable to parenteral dosage forms but is as convenient and easy to use for the patient as oral solid…”
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Engineering Microneedle Patches for Improved Penetration: Analysis, Skin Models and Factors Affecting Needle Insertion by Makvandi, Pooyan, Kirkby, Melissa, Hutton, Aaron R. J., Shabani, Majid, Yiu, Cynthia K. Y., Baghbantaraghdari, Zahra, Jamaledin, Rezvan, Carlotti, Marco, Mazzolai, Barbara, Mattoli, Virgilio, Donnelly, Ryan F.

“…Highlights Factors affecting microneedle insertion into skin are reviewed. The use of artificial and computational skin models for the simulation of needle…”
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Transdermal Drug Delivery Mediated by Microneedle Arrays: Innovations and Barriers to Success by Caffarel-Salvador, Ester, Donnelly, Ryan F

“…Microneedles (MN) offer a simple, minimally invasive and reduced pain alternative to hypodermic needles for drug delivery, including vaccines. Previous studies…”
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Hydrogel-Forming Microneedle Arrays Allow Detection of Drugs and Glucose In Vivo: Potential for Use in Diagnosis and Therapeutic Drug Monitoring by Caffarel-Salvador, Ester, Brady, Aaron J, Eltayib, Eyman, Meng, Teng, Alonso-Vicente, Ana, Gonzalez-Vazquez, Patricia, Torrisi, Barbara M, Vicente-Perez, Eva Maria, Mooney, Karen, Jones, David S, Bell, Steven E J, McCoy, Colin P, McCarthy, Helen O, McElnay, James C, Donnelly, Ryan F

“…We describe, for the first time the use of hydrogel-forming microneedle (MN) arrays for minimally-invasive extraction and quantification of drug substances and…”
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Nanosuspension-Based Dissolving Microneedle Arrays for Intradermal Delivery of Curcumin by Abdelghany, Sharif, Tekko, Ismaiel A, Vora, Lalitkumar, Larrañeta, Eneko, Permana, Andi Dian, Donnelly, Ryan F

“…The objective of this study was to evaluate the intradermal delivery of curcumin utilising poly(vinylalcohol) (PVA)-based microneedles loaded with curcumin…”
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Synthesis and Characterization of Lignin Hydrogels for Potential Applications as Drug Eluting Antimicrobial Coatings for Medical Materials by Larrañeta, Eneko, Imízcoz, Mikel, Toh, Jie X, Irwin, Nicola J, Ripolin, Anastasia, Perminova, Anastasia, Domínguez-Robles, Juan, Rodríguez, Alejandro, Donnelly, Ryan F

“…Lignin is the second most abundant biopolymer on the planet. It is a biocompatible, cheap, environmentally friendly and readily accessible material. It has…”
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Microarray Patches: Poking a Hole in the Challenges Faced When Delivering Poorly Soluble Drugs by Paredes, Alejandro J., McKenna, Peter E., Ramöller, Inken K., Naser, Yara A., Volpe‐Zanutto, Fabiana, Li, Mingshan, Abbate, M. T. A., Zhao, Li, Zhang, Chunyang, Abu‐Ershaid, Juhaina M., Dai, Xianbing, Donnelly, Ryan F.

“…Poorly soluble drugs constitute more than 60% of currently marketed pharmaceuticals with over two‐thirds of promising new chemical entities failing to enter a…”
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Cellulose Nanofibers and Other Biopolymers for Biomedical Applications. A Review by Moohan, John, Stewart, Sarah A., Espinosa, Eduardo, Rosal, Antonio, Rodríguez, Alejandro, Larrañeta, Eneko, Donnelly, Ryan F., Domínguez-Robles, Juan

“…Biopolymers are materials synthesised or derived from natural sources, such as plants, animals, microorganisms or any other living organism. The use of these…”
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Antioxidant PLA Composites Containing Lignin for 3D Printing Applications: A Potential Material for Healthcare Applications by Domínguez-Robles, Juan, Martin, Niamh K, Fong, Mun Leon, Stewart, Sarah A, Irwin, Nicola J, Rial-Hermida, María Isabel, Donnelly, Ryan F, Larrañeta, Eneko

“…Lignin (LIG) is a natural biopolymer with well-known antioxidant capabilities. Accordingly, in the present work, a method to combine LIG with poly(lactic acid)…”
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Hydrogel-forming microneedles prepared from "super swelling" polymers combined with lyophilised wafers for transdermal drug delivery by Donnelly, Ryan F, McCrudden, Maelíosa T C, Zaid Alkilani, Ahlam, Larrañeta, Eneko, McAlister, Emma, Courtenay, Aaron J, Kearney, Mary-Carmel, Singh, Thakur Raghu Raj, McCarthy, Helen O, Kett, Victoria L, Caffarel-Salvador, Ester, Al-Zahrani, Sharifa, Woolfson, A David

“…We describe, for the first time, hydrogel-forming microneedle arrays prepared from "super swelling" polymeric compositions. We produced a microneedle…”
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Development of a Biodegradable Subcutaneous Implant for Prolonged Drug Delivery Using 3D Printing by Stewart, Sarah A, Domínguez-Robles, Juan, McIlorum, Victoria J, Mancuso, Elena, Lamprou, Dimitrios A, Donnelly, Ryan F, Larrañeta, Eneko

“…Implantable drug delivery devices offer many advantages over other routes of drug delivery. Most significantly, the delivery of lower doses of drug, thus,…”
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